ExPASy Proteomics Server

Accession	MF_00214
Dates	1-JUN-2001 (Created) 25-NOV-2009 (Last updated, Version 30)

Data class

Protein

Predictors

HAMAP; MF_00214; [distribution of match scores in UniProtKB];[seed alignment for MF_00214]

Names

AroD

Identifier

AROD

Protein name

RecName: Full=3-dehydroquinate dehydratase; Short=3-dehydroquinase; EC=4.2.1.10; AltName: Full=Type I DHQase;

Gene name

aroD

CATALYTIC ACTIVITY: 3-dehydroquinate = 3-dehydroshikimate + H(2)O.

PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the type-I 3-dehydroquinase family.

Pfam	PF01487; DHquinase_I; 1;
TIGRFAMs	TIGR01093; aroD; 1;
PROSITE	PS01028; DEHYDROQUINASE_I; 1;

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Lyase, Schiff base.

GO:0003855; Molecular function: 3-dehydroquinate dehydratase activity.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.

From: AROD_ECOLI (P05194)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		143		143		Proton acceptor (By similarity)		H
ACT_SITE		170		170		Schiff-base intermediate with substrate (By similarity)		K

Size range:	196-272 amino acids
Related UniRules:	None
Template:	P05194 (AROD_ECOLI); P24670 (AROD_SALTI): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: MF_00222 (aroE), <Chorismate mutase>
Duplicate:	None
Plasmid encoded:	None
Comments:	There are two type of DHQases, B.subtilis seems to have both. AroD can be confused with of DHQases involved in catabolism (quiB) or in other pathways (example ebsD).