Search for
You are here: ExPASy CH  > Databases  > Around UniProtKB  > HAMAP

Home Proteomes Families Documents Downloads Links
HAMAP annotation rule: MF_00202

Send feedback new

General rule information

Accession MF_00202
Dates 1-JUN-2001 (Created)
25-NOV-2009 (Last updated, Version 27)
Data class Protein
Predictors HAMAP; MF_00202; [distribution of match scores in UniProtKB];[seed alignment for MF_00202]
Names Idi


Propagated annotation

Identifier, protein and gene names
Identifier IDI
Protein name
RecName: Full=Isopentenyl-diphosphate Delta-isomerase;
Short=IPP isomerase;
EC=5.3.3.2;
AltName: Full=Isopentenyl pyrophosphate isomerase;
AltName: Full=IPP:DMAPP isomerase;
Gene name idi
Comments
FUNCTION: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity).
CATALYTIC ACTIVITY: Isopentenyl diphosphate = dimethylallyl diphosphate.

case <FT:6>
COFACTOR: Binds 1 magnesium ion per subunit. The magnesium ion binds only when substrate is bound (By similarity).
end case


case <FTGroup:1>
COFACTOR: Binds 1 manganese ion per subunit (By similarity).
end case

PATHWAY: Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.

case <Property:PHOTOSYN>
PATHWAY: Porphyrin biosynthesis; chlorophyll biosynthesis.
end case


case <OC:Enterobacteriaceae>
SUBUNIT: Homodimer (By similarity).
end case

SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the IPP isomerase type 1 family.
Cross-references
Pfam PF00293; NUDIX; 1;
Keywords
Cytoplasm, Isomerase, Isoprene biosynthesis.

case <Property:PHOTOSYN>
Chlorophyll biosynthesis, Photosynthesis.
end case


case <FT:6>
Magnesium.
end case


case <FTGroup:1>
Manganese.
end case


case <FTGroup:1> or <FT:6>
Metal-binding.
end case

Gene Ontology
GO:0004452; Molecular function: isopentenyl-diphosphate delta-isomerase activity.

case <Property:PHOTOSYN>
GO:0015995; Biological process: chlorophyll biosynthetic process.
end case

GO:0008299; Biological process: isoprenoid biosynthetic process.

case <Property:PHOTOSYN>
GO:0015979; Biological process: photosynthesis.
end case

GO:0005737; Cellular component: cytoplasm.
Features
From: IDI_ECOLI (Q46822)
Key     From     To       Description   Condition   FTGroup
ACT_SITE     67     67       By similarity   C  
ACT_SITE     116     116       By similarity   E  
 
METAL     25     25       Manganese (By similarity)   H   1
METAL     32     32       Manganese (By similarity)   H   1
METAL     69     69       Manganese (By similarity)   H   1
 
METAL     87     87       Magnesium (By similarity)   E  
 
METAL     114     114       Manganese (By similarity)   E   1
METAL     116     116       Manganese (By similarity)   E   1


Additional information

Size range: 175-213 amino acids
Related UniRules: None
Template: Q46822 (IDI_ECOLI)
Scope: Bacteria; Actinobacteria
Bacteria; Proteobacteria
Archaea; Halobacteria
Fusion: Nter: None; Cter: None
Duplicate: in AZOSE, PHOLL
Plasmid encoded: in AGRRH, AZOSE
Comments: HALSA and HALMA putative conserved active site cysteine residue is replaced by an alanine. HALSA also possess a type-2 IDI.

View rule in raw text format (no links)



UniProtKB rule member sequences