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HAMAP annotation rule: MF_00183

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General rule information

Accession MF_00183
Dates 1-JUN-2001 (Created)
25-NOV-2009 (Last updated, Version 24)
Data class Protein
Predictors HAMAP; MF_00183; [distribution of match scores in UniProtKB];[seed alignment for MF_00183]
Names DXP_reductoisom


Propagated annotation

Identifier, protein and gene names
Identifier DXR
Protein name
RecName: Full=1-deoxy-D-xylulose 5-phosphate reductoisomerase;
Short=DXP reductoisomerase;
EC=1.1.1.267;
AltName: Full=1-deoxyxylulose-5-phosphate reductoisomerase;
AltName: Full=2-C-methyl-D-erythritol 4-phosphate synthase;
Gene name dxr
Comments
FUNCTION: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).
CATALYTIC ACTIVITY: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
COFACTOR: Divalent cation (By similarity).
PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.

case <OC:Enterobacteriaceae>
SUBUNIT: Homodimer (By similarity).
end case

SIMILARITY: Belongs to the DXR family.
Cross-references
Pfam PF02670; DXP_reductoisom; 1;
TIGRFAMs TIGR00243; Dxr; 1;
Keywords
Isoprene biosynthesis, Metal-binding, NADP, Oxidoreductase.
Gene Ontology
GO:0030604; Molecular function: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity.
GO:0016114; Biological process: terpenoid biosynthetic process.
Features
From: DXR_ECOLI (P45568)
Key     From     To       Description   Condition   FTGroup
NP_BIND     7     36       NADP (By similarity)      
 
METAL     150     150       Divalent metal cation (By similarity)   D   1
METAL     152     152       Divalent metal cation (By similarity)   E   1
METAL     231     231       Divalent metal cation (By similarity)   E   1
 
BINDING (Optional)     125     125       Substrate (By similarity)   K  
BINDING (Optional)     152     152       Substrate (By similarity)   E  
BINDING (Optional)     186     186       Substrate (By similarity)   S  
BINDING (Optional)     209     209       Substrate (By similarity)   H  
BINDING (Optional)     231     231       Substrate (By similarity)   E  


Additional information

Size range: 356-455 amino acids
Related UniRules: None
Template: P45568 (DXR_ECOLI); Q9KGU6 (DXR_PSEAE); Q9RCT1 (DXR_SYNP6); Q9X5F2 (DXR_ZYMMO): [Recover all]
Scope: Bacteria
Fusion: Nter: None; Cter: None
Duplicate: in BACAN, BACCR, BACCZ, BACHK
Plasmid encoded: None
Comments: Possible wrong start in MANSM, PASMU and STRCO

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UniProtKB rule member sequences