Search for
You are here: ExPASy CH  > Databases  > Around UniProtKB  > HAMAP

Home Proteomes Families Documents Downloads Links
HAMAP annotation rule: MF_00171

Send feedback new

General rule information

Accession MF_00171
Dates 1-JUN-2001 (Created)
25-NOV-2009 (Last updated, Version 21)
Data class Protein
Predictors HAMAP; MF_00171; [distribution of match scores in UniProtKB];[seed alignment for MF_00171]
Names TruA


Propagated annotation

Identifier, protein and gene names
Identifier TRUA
Protein name
RecName: Full=tRNA pseudouridine synthase A;
EC=5.4.99.12;
AltName: Full=tRNA-uridine isomerase I;
AltName: Full=tRNA pseudouridylate synthase I;
Gene name truA
Comments
FUNCTION: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity).
CATALYTIC ACTIVITY: tRNA uridine = tRNA pseudouridine.

case <OC:Enterobacteriaceae>
SUBUNIT: Homodimer (By similarity).
end case

SIMILARITY: Belongs to the tRNA pseudouridine synthase truA family.
Cross-references
Pfam PF01416; PseudoU_synth_1; 1;
TIGRFAMs TIGR00071; hisT_truA; 1;
Keywords
Isomerase, tRNA processing.
Gene Ontology
GO:0009982; Molecular function: pseudouridine synthase activity.
GO:0031119; Biological process: tRNA pseudouridine synthesis.
Features
From: TRUA_ECOLI (P07649)
Key     From     To       Description   Condition   FTGroup
ACT_SITE     60     60       Nucleophile (By similarity)   D  
case <OC:Enterobacteriaceae>
Key     From     To       Description   Condition   FTGroup
BINDING     118     118       Substrate (By similarity)   Y  
BINDING     245     245       Substrate (By similarity)   L  
end case



Additional information

Size range: 240-304 amino acids
Related UniRules: None
Template: P07649 (TRUA_ECOLI)
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in BACAN, BACC1, BACCR, BACCZ, BACHK, CLOPE, CLOTE, DESPS, PARUW
Plasmid encoded: None
Comments: Possible wrong start in MYCLE, MYCTU and MYCPA. Divergent LEPIN and NANEQ; not shown in alignment and not used in size range.

View rule in raw text format (no links)



UniProtKB rule member sequences