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HAMAP annotation rule: MF_00150

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General rule information

Accession MF_00150
Dates 1-JUN-2001 (Created)
25-NOV-2009 (Last updated, Version 37)
Data class Protein
Predictors HAMAP; MF_00150; [distribution of match scores in UniProtKB];[seed alignment for MF_00150]
Names ArgC_type1


Propagated annotation

Identifier, protein and gene names
Identifier ARGC

case not <OC:Deinococci> and not <OC:Pyrococcus> and not <OC:Crenarchaeota>
Protein name
RecName: Full=N-acetyl-gamma-glutamyl-phosphate reductase;
Short=AGPR;
EC=1.2.1.38;
AltName: Full=N-acetyl-glutamate semialdehyde dehydrogenase;
Short=NAGSA dehydrogenase;
Gene name argC
end case


case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
Protein name
RecName: Full=N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase;
Short=AGPR;
EC=1.2.1.38;
EC=1.2.1.-;
AltName: Full=N-acetyl-glutamate semialdehyde/N-acetyl-aminoadipate semialdehyde dehydrogenase;
Short=NAGSA dehydrogenase;
Gene name argC, lysY
end case

Comments

case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
FUNCTION: Involved in both the arginine and lysine biosynthetic pathways (By similarity).
end case

CATALYTIC ACTIVITY: N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.

case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
CATALYTIC ACTIVITY: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP(+) + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH.
end case

PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.

case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5.
end case

SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
Cross-references
Pfam PF01118; Semialdhyde_dh; 1;
PROSITE PS01224; ARGC; 1;
Keywords
Cytoplasm, Amino-acid biosynthesis, Arginine biosynthesis.

case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
Lysine biosynthesis.
end case

Oxidoreductase, NADP.
Gene Ontology
GO:0003942; Molecular function: N-acetyl-gamma-glutamyl-phosphate reductase activity.
GO:0006526; Biological process: arginine biosynthetic process.

case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
GO:0009085; Biological process: lysine biosynthetic process.
end case

GO:0005737; Cellular component: cytoplasm.
Features
From: ARGC_ECOLI (P11446)
Key     From     To       Description   Condition   FTGroup
ACT_SITE     154     154       By similarity   C  


Additional information

Size range: 308-364 amino acids
Related UniRules: MF_01110 (ARGC)
Template: P11446 (ARGC_ECOLI); Q980X1 (ARGC_SULSO): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in LACPL, THETH
Plasmid encoded: None

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