ExPASy Proteomics Server

Accession	MF_00131
Dates	1-JUN-2001 (Created) 25-NOV-2009 (Last updated, Version 34)

Data class

Protein

Predictors

HAMAP; MF_00131; [distribution of match scores in UniProtKB];[seed alignment for MF_00131]

Names

Trp_synth_alpha

Identifier

TRPA

Protein name

RecName: Full=Tryptophan synthase alpha chain; EC=4.2.1.20;

Gene name

trpA

FUNCTION: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate (By similarity).

CATALYTIC ACTIVITY: L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H(2)O.

PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.

SUBUNIT: Tetramer of two alpha and two beta chains (By similarity).

SUBCELLULAR LOCATION: Plastid, chloroplast.

SIMILARITY: Belongs to the trpA family.

Pfam	PF00290; Trp_syntA; 1;
TIGRFAMs	TIGR00262; trpA; 1;
PROSITE	PS00167; TRP_SYNTHASE_ALPHA; 1;

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis, Lyase.

GO:0004834; Molecular function: tryptophan synthase activity.
GO:0000162; Biological process: tryptophan biosynthetic process.

GO:0009507; Cellular component: chloroplast.

From: TRPA_ECOLI (P0A877)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		49		49		Proton acceptor (By similarity)		E
ACT_SITE		60		60		Proton acceptor (By similarity)		[DE]

Size range:	239-293 amino acids
Related UniRules:	None
Template:	P0A877 (TRPA_ECOLI); P00929 (TRPA_SALTY); Q8U094 (TRPA_PYRFU): [Recover all]
Scope:	Bacteria Archaea Plastid
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Highly divergent CHLTR; sequence not included in alignment