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HAMAP annotation rule: MF_00127

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General rule information

Accession MF_00127
Dates 1-JUN-2001 (Created)
25-NOV-2009 (Last updated, Version 36)
Data class Protein
Predictors HAMAP; MF_00127; [distribution of match scores in UniProtKB];[seed alignment for MF_00127]
Names His_tRNA_synth


Propagated annotation

Identifier, protein and gene names
Identifier SYH

case <OC:Bacteria> or <OC:Archaea>
Protein name
RecName: Full=Histidyl-tRNA synthetase;
EC=6.1.1.21;
AltName: Full=Histidine--tRNA ligase;
Short=HisRS;

else case <OG:Chloroplast>
Protein name
RecName: Full=Histidyl-tRNA synthetase, chloroplastic;
EC=6.1.1.21;
AltName: Full=Histidine--tRNA ligase;
Short=HisRS;
end case

Gene name hisS
Comments
CATALYTIC ACTIVITY: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

case <OC:Bacteria>
SUBUNIT: Homodimer (By similarity).
end case


case not <OG:Chloroplast>
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
end case


case <OG:Chloroplast>
SUBCELLULAR LOCATION: Plastid, chloroplast.
end case

SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
Cross-references
Pfam PF00587; tRNA-synt_2b; 1;
PF03129; HGTP_anticodon; 1;
TIGRFAMs TIGR00442; hisS; 1;
PROSITE PS50862; AA_TRNA_LIGASE_II; 1;
Keywords

case not <OG:Chloroplast>
Cytoplasm.
end case

Aminoacyl-tRNA synthetase, Protein biosynthesis, Ligase, ATP-binding, Nucleotide-binding.
Gene Ontology
GO:0005524; Molecular function: ATP binding.
GO:0004821; Molecular function: histidine-tRNA ligase activity.
GO:0006427; Biological process: histidyl-tRNA aminoacylation.

case not <OG:Chloroplast>
GO:0005737; Cellular component: cytoplasm.
end case


case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case



Additional information

Size range: 403-523 amino acids
Related UniRules: MF_00125 (HISZ)
Template: P60906 (SYH_ECOLI); P60911 (SYH_STAAU); P56194 (SYH_THET8): [Recover all]
Scope: Bacteria
Archaea
Plastid
Fusion: Nter: None; Cter: None
Duplicate: in BACAN, BACC1, BACCR, BACCZ, BACHK, BACSK
Plasmid encoded: None
Comments: Divergent TROW8 and TROWT; not shown in alignment. It is difficult to distinguish between hisS and hisZ families.

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UniProtKB rule member sequences