ExPASy Proteomics Server

Accession	MF_00079
Dates	1-JUN-2001 (Created) 25-NOV-2009 (Last updated, Version 30)

Data class

Protein

Predictors

HAMAP; MF_00079; [distribution of match scores in UniProtKB];[seed alignment for MF_00079]

Names

HisG_Long

Identifier

HIS1

Protein name

RecName: Full=ATP phosphoribosyltransferase; Short=ATP-PRTase; Short=ATP-PRT; EC=2.4.2.17;

Gene name

hisG

FUNCTION: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity (By similarity).

CATALYTIC ACTIVITY: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.

COFACTOR: Magnesium (By similarity).

ENZYME REGULATION: Feedback inhibited by histidine (By similarity).

PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.

SUBUNIT: Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.

Pfam	PF01634; HisG; 1;
TIGRFAMs	TIGR00070; hisG; 1;
PROSITE	PS01316; ATP_P_PHORIBOSYLTR; 1;

Amino-acid biosynthesis, ATP-binding, Cytoplasm, Glycosyltransferase, Histidine biosynthesis, Magnesium, Metal-binding, Nucleotide-binding, Transferase.

GO:0003879; Molecular function: ATP phosphoribosyltransferase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Size range:	281-325 amino acids
Related UniRules:	MF_01018 (HIS1)
Template:	P60757 (HIS1_ECOLI); P00499 (HIS1_SALTY); P60759 (HIS1_MYCTU): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Possible wrong start in HAEIN. Possible wrong start in ARCFU; not shown in alignment and not taken into account in size range. See MF_01018 for the entry relevant to the "short" hisG.