ExPASy Proteomics Server

Accession	MF_00004
Dates	1-JUN-2001 (Created) 25-NOV-2009 (Last updated, Version 22)

Data class

Protein

Predictors

HAMAP; MF_00004; [distribution of match scores in UniProtKB];[seed alignment for MF_00004]

Names

Aden_phosphoribosyltr

Identifier

APT

Protein name

RecName: Full=Adenine phosphoribosyltransferase; Short=APRT; EC=2.4.2.7;

Gene name

apt

FUNCTION: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity).

CATALYTIC ACTIVITY: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.

PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Pfam	PF00156; Pribosyltran; 1;
TIGRFAMs	TIGR01090; apt; 1;
PROSITE	PS00103; PUR_PYR_PR_TRANSFER; 1;

Cytoplasm, Transferase, Glycosyltransferase, Purine salvage.

GO:0003999; Molecular function: adenine phosphoribosyltransferase activity.
GO:0006168; Biological process: adenine salvage.
GO:0009116; Biological process: nucleoside metabolic process.
GO:0005737; Cellular component: cytoplasm.

Size range:	165-223 amino acids
Related UniRules:	None
Template:	P69503 (APT_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in METM5, METM7, METMP, METVS, RHIEC
Plasmid encoded:	in RHIEC
Comments:	Possible wrong start in MYCTU