[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
TISSUE=Melanoma;
DOI=10.1073/pnas.022637199; PubMed=11805321 [NCBI, ExPASy, EBI, Israel, Japan]
Kang D.-C.,
Gopalkrishnan R.V.,
Wu Q.,
Jankowsky E.,
Pyle A.M.,
Fisher P.B.;
"mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties.";
Proc. Natl. Acad. Sci. U.S.A. 99:637-642(2002).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND VARIANT ARG-843.
TISSUE=Spleen;
DOI=10.1099/vir.0.19300-0; PubMed=14645903 [NCBI, ExPASy, EBI, Israel, Japan]
Cocude C.,
Truong M.-J.,
Billaut-Mulot O.,
Delsart V.,
Darcissac E.,
Capron A.,
Mouton Y.,
Bahr G.M.;
"A novel cellular RNA helicase, RH116, differentially regulates cell growth, programmed cell death and human immunodeficiency virus type 1 replication.";
J. Gen. Virol. 84:3215-3225(2003).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS ARG-843 AND THR-946.
TISSUE=Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] OF 475-1025 (ISOFORM 1), AND VARIANTS ARG-843 AND THR-946.
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T.,
Suzuki Y.,
Nishikawa T.,
Otsuki T.,
Sugiyama T.,
Irie R.,
Wakamatsu A.,
Hayashi K.,
Sato H.,
Nagai K.,
Kimura K.,
Makita H.,
Sekine M.,
Obayashi M.,
Nishi T.,
Shibahara T.,
Tanaka T.,
Ishii S.,
Yamamoto J., ![]()
Saito K.,
Kawai Y.,
Isono Y.,
Nakamura Y.,
Nagahari K.,
Murakami K.,
Yasuda T.,
Iwayanagi T.,
Wagatsuma M.,
Shiratori A.,
Sudo H.,
Hosoiri T.,
Kaku Y.,
Kodaira H.,
Kondo H.,
Sugawara M.,
Takahashi M.,
Kanda K.,
Yokoi T.,
Furuya T.,
Kikkawa E.,
Omura Y.,
Abe K.,
Kamihara K.,
Katsuta N.,
Sato K.,
Tanikawa M.,
Yamazaki M.,
Ninomiya K.,
Ishibashi T.,
Yamashita H.,
Murakawa K.,
Fujimori K.,
Tanai H.,
Kimata M.,
Watanabe M.,
Hiraoka S.,
Chiba Y.,
Ishida S.,
Ono Y.,
Takiguchi S.,
Watanabe S.,
Yosida M.,
Hotuta T.,
Kusano J.,
Kanehori K.,
Takahashi-Fujii A.,
Hara H.,
Tanase T.-O.,
Nomura Y.,
Togiya S.,
Komai F.,
Hara R.,
Takeuchi K.,
Arita M.,
Imose N.,
Musashino K.,
Yuuki H.,
Oshima A.,
Sasaki N.,
Aotsuka S.,
Yoshikawa Y.,
Matsunawa H.,
Ichihara T.,
Shiohata N.,
Sano S.,
Moriya S.,
Momiyama H.,
Satoh N.,
Takami S.,
Terashima Y.,
Suzuki O.,
Nakagawa S.,
Senoh A.,
Mizoguchi H.,
Goto Y.,
Shimizu F.,
Wakebe H.,
Hishigaki H.,
Watanabe T.,
Sugiyama A.,
Takemoto M.,
Kawakami B.,
Yamazaki M.,
Watanabe K.,
Kumagai A.,
Itakura S.,
Fukuzumi Y.,
Fujimori Y.,
Komiyama M.,
Tashiro H.,
Tanigami A.,
Fujiwara T.,
Ono T.,
Yamada K.,
Fujii Y.,
Ozaki K.,
Hirao M.,
Ohmori Y.,
Kawabata A.,
Hikiji T.,
Kobatake N.,
Inagaki H.,
Ikema Y.,
Okamoto S.,
Okitani R.,
Kawakami T.,
Noguchi S.,
Itoh T.,
Shigeta K.,
Senba T.,
Matsumura K.,
Nakajima Y.,
Mizuno T.,
Morinaga M.,
Sasaki M.,
Togashi T.,
Oyama M.,
Hata H.,
Watanabe M.,
Komatsu T.,
Mizushima-Sugano J.,
Satoh T.,
Shirai Y.,
Takahashi Y.,
Nakagawa K.,
Okumura K.,
Nagase T.,
Nomura N.,
Kikuchi H.,
Masuho Y.,
Yamashita R.,
Nakai K.,
Yada T.,
Nakamura Y.,
Ohara O.,
Isogai T.,
Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
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[5]
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MUTAGENESIS OF ASP-251 AND GLU-444, AND TISSUE SPECIFICITY.
DOI=10.1016/S0960-9822(02)00842-4; PubMed=12015121 [NCBI, ExPASy, EBI, Israel, Japan]
Kovacsovics M.,
Martinon F.,
Micheau O.,
Bodmer J.-L.,
Hofmann K.,
Tschopp J.;
"Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation.";
Curr. Biol. 12:838-843(2002).
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[6]
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ERRATUM.
Kovacsovics M.,
Martinon F.,
Micheau O.,
Bodmer J.-L.,
Hofmann K.,
Tschopp J.;
Curr. Biol. 12:1633-1633(2002).
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[7]
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INTERACTION WITH PARAMYXOVIRUSES V PROTEIN.
DOI=10.1073/pnas.0407639101; PubMed=15563593 [NCBI, ExPASy, EBI, Israel, Japan]
Andrejeva J.,
Childs K.S.,
Young D.F.,
Carlos T.S.,
Stock N.,
Goodbourn S.,
Randall R.E.;
"The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter.";
Proc. Natl. Acad. Sci. U.S.A. 101:17264-17269(2004).
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[8]
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INTERACTION WITH MAVS.
DOI=10.1038/ni1243; PubMed=16127453 [NCBI, ExPASy, EBI, Israel, Japan]
Kawai T.,
Takahashi K.,
Sato S.,
Coban C.,
Kumar H.,
Kato H.,
Ishii K.J.,
Takeuchi O.,
Akira S.;
"IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.";
Nat. Immunol. 6:981-988(2005).
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[9]
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INTERACTION WITH MAVS.
DOI=10.1038/nature04193; PubMed=16177806 [NCBI, ExPASy, EBI, Israel, Japan]
Meylan E.,
Curran J.,
Hofmann K.,
Moradpour D.,
Binder M.,
Bartenschlager R.,
Tschopp J.;
"Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.";
Nature 437:1167-1172(2005).
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[10]
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IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
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[11]
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VARIANT THR-946, AND ASSOCIATION WITH INSULIN-DEPENDENT DIABETES MELLITUS 19.
DOI=10.1038/ng1800; PubMed=16699517 [NCBI, ExPASy, EBI, Israel, Japan]
Smyth D.J.,
Cooper J.D.,
Bailey R.,
Field S.,
Burren O.,
Smink L.J.,
Guja C.,
Ionescu-Tirgoviste C.,
Widmer B.,
Dunger D.B.,
Savage D.A.,
Walker N.M.,
Clayton D.G.,
Todd J.A.;
"A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.";
Nat. Genet. 38:617-619(2006).
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