ID   FAM3C_HUMAN             Reviewed;         227 AA.
AC   Q92520; A6NDN2; A8K3R7;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   22-JUL-2008, entry version 63.
DE   RecName: Full=Protein FAM3C;
DE   Flags: Precursor;
GN   Name=FAM3C; ORFNames=GS3786;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone;
RA   Ohno I., Hashimoto J., Takaoka K., Ochi T., Okubo K., Matsubara K.;
RT   "The cloning of a cDNA for novel genes expressed in human
RT   osteoblast.";
RL   Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22737999; PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, Duodenum, and Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   CHARACTERIZATION.
RX   MEDLINE=22150867; PubMed=12160727; DOI=10.1006/geno.2002.6816;
RA   Zhu Y., Xu G., Patel A., McLaughlin M.M., Silverman C., Knecht K.A.,
RA   Sweitzer S., Li X., McDonnell P., Mirabile R., Zimmerman D., Boyce R.,
RA   Tierney L.A., Hu E., Livi G.P., Wolf B.A., Abdel-Meguid S.S.,
RA   Rose G.D., Aurora R., Hensley P., Briggs M., Young P.R.;
RT   "Cloning, expression, and initial characterization of a novel
RT   cytokine-like gene family.";
RL   Genomics 80:144-150(2002).
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SIMILARITY: Belongs to the FAM3 family.
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DR   EMBL; D87120; BAA13251.1; -; mRNA.
DR   EMBL; AK290682; BAF83371.1; -; mRNA.
DR   EMBL; AK292731; BAF85420.1; -; mRNA.
DR   EMBL; AC006364; AAQ96872.1; -; Genomic_DNA.
DR   EMBL; CH471070; EAW83558.1; -; Genomic_DNA.
DR   EMBL; BC024200; AAH24200.1; -; mRNA.
DR   EMBL; BC046932; AAH46932.1; -; mRNA.
DR   EMBL; BC068526; AAH68526.1; -; mRNA.
DR   RefSeq; NP_001035109.1; -.
DR   RefSeq; NP_055703.1; -.
DR   UniGene; Hs.272375; -.
DR   UniGene; Hs.434053; -.
DR   PeptideAtlas; Q92520; -.
DR   Ensembl; ENSG00000174028; Homo sapiens.
DR   Ensembl; ENSG00000196937; Homo sapiens.
DR   GeneID; 10447; -.
DR   KEGG; hsa:10447; -.
DR   H-InvDB; HIX0025328; -.
DR   H-InvDB; HIX0056520; -.
DR   HGNC; HGNC:18664; FAM3C.
DR   MIM; 608618; gene.
DR   PharmGKB; PA38627; -.
DR   HOGENOM; Q92520; -.
DR   HOVERGEN; Q92520; -.
DR   LinkHub; Q92520; -.
DR   ArrayExpress; Q92520; -.
DR   CleanEx; HS_FAM3C; -.
DR   GermOnline; ENSG00000196937; Homo sapiens.
DR   GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; NAS:UniProtKB.
PE   1: Evidence at protein level;
KW   Secreted; Signal.
FT   SIGNAL        1     24       Potential.
FT   CHAIN        25    227       Protein FAM3C.
FT                                /FTId=PRO_0000008752.
FT   DISULFID     58    221       Potential.
FT   DISULFID     64     86       Potential.
SQ   SEQUENCE   227 AA;  24680 MW;  6DC94B259052647F CRC64;
     MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDTAARS TKPPRYKCGI
     SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV GRGINVALAN GKTGEVLDTK
     YFDMWGGDVA PFIEFLKAIQ DGTIVLMGTY DDGATKLNDE ARRLIADLGS TSITNLGFRD
     NWVFCGGKGI KTKSPFEQHI KNNKDTNKYE GWPEVVEMEG CIPQKQD
//