[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=1732733 [NCBI, ExPASy, EBI, Israel, Japan] Chen J.D., Chan C.S., Pirrotta V.; "Conserved DNA binding and self-association domains of the Drosophila zeste protein."; Mol. Cell. Biol. 12:598-608(1992).

Comments

FUNCTION: Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter (By similarity).
SUBUNIT: Self-associates forming complexes of several hundred monomers (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M76700; AAA29052.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A42020; A42020.

3D structure databases

ModBase

Q24762.

Organism-specific databases

FlyBase

FBgn0013149; Dvir\z.

Ontologies

GO:0005634;	Cellular component: nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0003677;	Molecular function: DNA binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006355;	Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0006350;	Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Other

ProtoNet

Q24762.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

DNA-binding; Nucleus; Transcription; Transcription regulation.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 618`	`618`	`Regulatory protein zeste.`	`PRO_0000066576`
`DNA_BIND`	`66 146`	`81`	`By similarity.`
`COMPBIAS`	`171 468`	`298`	`Ala/Gln-rich (OPA repeat involved in transcriptional activation or repression at different target loci).`

Sequence information

Length: 618 AA [This is the length of the unprocessed precursor]

Molecular weight: 68102 Da [This is the MW of the unprocessed precursor]

CRC64: 3127180B10AFDC0B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSAAGDAGAG AANGSNNVAV VQATVSVSGN ISVGDGSPNN NNNNNANGNT NGNSNNNGST 

        70         80         90        100        110        120 
AGSSKGQLPL TPRFTAEEKD VLYTLFHLHE EVIDIKHRKK QRNKYSVRDT WDKIVRDFNS 

       130        140        150        160        170        180 
HPHVSAMRNI KQIQKFWLNS RLRKQYPYRD GSASGGSAGL GKVGTVSASA QQQQQQQQQQ 

       190        200        210        220        230        240 
QQQQQQQHHD SVKVEPEYQI SPEASEHNPQ GEPFDEIEMD GNDVSEMEDD PLEAQQQQQQ 

       250        260        270        280        290        300 
QQQQQQQAAA QAQAEAQQQQ QQQSAVAEMQ KLQVSAAVAA ANASMLNTHR INVDSISAEK 

       310        320        330        340        350        360 
LTLNDLLHFK PARHDEIILQ IKHPTDATAT QIHTIPAQPQ QHTMATITAG GYNQQIISEI 

       370        380        390        400        410        420 
KPQQITLAQY QAQQHQQAQA RLRPGQAQQL AQQQLAAQQQ QLAVAAAAAH QQQNSSSAAA 

       430        440        450        460        470        480 
VVVQQHQQQQ QQQQHQQQQQ QQQVQQQQQQ QQQAAAAAAA VKMQLTGGTP TFTFSALPTV 

       490        500        510        520        530        540 
TAATSVPVTV PVPVTVPVTA APAAVSNVSV SGAGTLPTGA QQQLQLQQQQ QQQQQQQQQQ 

       550        560        570        580        590        600 
QQAGDSYEER INYFKVKEAE LRCKEQQLAT EAKKIELNKA QDELKYMREV HRLRVEELKM 

       610 
KIRILQKEEE QLQKCSST

Q24762 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools