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UniProtKB/Swiss-Prot entry P04293

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DPOL_HHV11
Primary accession number P04293
Secondary accession numbers None
Integrated into Swiss-Prot on March 20, 1987
Sequence was last modified on July 1, 1989 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 65)
Name and origin of the protein
Protein name DNA polymerase
Synonym EC 2.7.7.7
Gene name
Name: UL30
From
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [TaxID: 10299] 
Taxonomy Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
Virus host Homo sapiens (Human) [TaxID: 9606]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2839594 [NCBI, ExPASy, EBI, Israel, Japan]
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.;
"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1.";
J. Gen. Virol. 69:1531-1574(1988).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1093/nar/13.22.8143; PubMed=2999714 [NCBI, ExPASy, EBI, Israel, Japan]
Quinn J.P., McGeoch D.J.;
"DNA sequence of the region in the genome of herpes simplex virus type 1 containing the genes for DNA polymerase and the major DNA binding protein.";
Nucleic Acids Res. 13:8143-8163(1985).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X14112; CAA32323.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X03181; CAA26941.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A00715; DJBEV1.
C30085; DJBEH7.
RefSeq NP_044632.1; -.
3D structure databases
SMR P04293; 60-640, 700-1110.
ModBase P04293.
Ontologies
GO
GO:0042025; Cellular component: host cell nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
GO:0003677; Molecular function: DNA binding (inferred from electronic annotation from UniProtKB-KW).
GO:0003887; Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from UniProtKB-KW).
GO:0000166; Molecular function: nucleotide binding (inferred from electronic annotation from InterPro).
GO:0006260; Biological process: DNA replication (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006172; DNA-dir_DNA_pol_B.
IPR006134; DNA-dir_DNA_pol_B_cons-reg.
IPR017966; DNA-dir_DNA_pol_B_cons_reg2.
IPR017964; DNA-dir_DNA_pol_B_CS.
IPR006133; DNA-dir_DNA_pol_B_exonuc.
Graphical view of domain structure.
PANTHER PTHR10322; DNA_pol_B; 1.
Pfam PF00136; DNA_pol_B; 1.
PF03104; DNA_pol_B_exo; 1.
Pfam graphical view of domain structure.
PRINTS PR00106; DNAPOLB.
SMART SM00486; POLBc; 1.
SMART graphical view of domain structure.
PROSITE PS00116; DNA_POLYMERASE_B; 1.
Genome annotation databases
GeneID 2703462; -.
Other
DrugBank DB00787; Aciclovir.
DB00426; Famciclovir.
DB00529; Foscarnet.
DB01004; Ganciclovir.
DB00249; Idoxuridine.
DB00299; Penciclovir.
DB00432; Trifluridine.
DB00577; Valaciclovir.
DB01610; Valganciclovir.
ProtoNet P04293.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; DNA replication; DNA-binding; DNA-directed DNA polymerase; Nucleotidyltransferase; Nucleus; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   1235  1235     DNA polymerase. PRO_0000046511
CONFLICT   114    126        VLRVGSGGFWPRR -> APPRRVGRLLAAA (in Ref. 2). 
Sequence information
Length: 1235 AA [This is the length of the unprocessed precursor] Molecular weight: 136421 Da [This is the MW of the unprocessed precursor] CRC64: E8CD41D6EDED8343 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MFSGGGGPLS PGGKSAARAA SGFFAPAGPR GASRGPPPCL RQNFYNPYLA PVGTQQKPTG 

        70         80         90        100        110        120 
PTQRHTYYSE CDEFRFIAPR VLDEDAPPEK RAGVHDGHLK RAPKVYCGGD ERDVLRVGSG 

       130        140        150        160        170        180 
GFWPRRSRLW GGVDHAPAGF NPTVTVFHVY DILENVEHAY GMRAAQFHAR FMDAITPTGT 

       190        200        210        220        230        240 
VITLLGLTPE GHRVAVHVYG TRQYFYMNKE EVDRHLQCRA PRDLCERMAA ALRESPGASF 

       250        260        270        280        290        300 
RGISADHFEA EVVERTDVYY YETRPALFYR VYVRSGRVLS YLCDNFCPAI KKYEGGVDAT 

       310        320        330        340        350        360 
TRFILDNPGF VTFGWYRLKP GRNNTLAQPA APMAFGTSSD VEFNCTADNL AIEGGMSDLP 

       370        380        390        400        410        420 
AYKLMCFDIE CKAGGEDELA FPVAGHPEDL VIQISCLLYD LSTTALEHVL LFSLGSCDLP 

       430        440        450        460        470        480 
ESHLNELAAR GLPTPVVLEF DSEFEMLLAF MTLVKQYGPE FVTGYNIINF DWPFLLAKLT 

       490        500        510        520        530        540 
DIYKVPLDGY GRMNGRGVFR VWDIGQSHFQ KRSKIKVNGM VNIDMYGIIT DKIKLSSYKL 

       550        560        570        580        590        600 
NAVAEAVLKD KKKDLSYRDI PAYYAAGPAQ RGVIGEYCIQ DSLLVGQLFF KFLPHLELSA 

       610        620        630        640        650        660 
VARLAGINIT RTIYDGQQIR VFTCLLRLAD QKGFILPDTQ GRFRGAGGEA PKRPAAARED 

       670        680        690        700        710        720 
EERPEEEGED EDEREEGGGE REPEGARETA GRHVGYQGAR VLDPTSGFHV NPVVVFDFAS 

       730        740        750        760        770        780 
LYPSIIQAHN LCFSTLSLRA DAVAHLEAGK DYLEIEVGGR RLFFVKAHVR ESLLSILLRD 

       790        800        810        820        830        840 
WLAMRKQIRS RIPQSSPEEA VLLDKQQAAI KVVCNSVYGF TGVQHGLLPC LHVAATVTTI 

       850        860        870        880        890        900 
GREMLLATRE YVHARWAAFE QLLADFPEAA DMRAPGPYSM RIIYGDTDSI FVLCRGLTAA 

       910        920        930        940        950        960 
GLTAVGDKMA SHISRALFLP PIKLECEKTF TKLLLIAKKK YIGVIYGGKM LIKGVDLVRK 

       970        980        990       1000       1010       1020 
NNCAFINRTS RALVDLLFYD DTVSGAAAAL AERPAEEWLA RPLPEGLQAF GAVLVDAHRR 

      1030       1040       1050       1060       1070       1080 
ITDPERDIQD FVLTAELSRH PRAYTNKRLA HLTVYYKLMA RRAQVPSIKD RIPYVIVAQT 

      1090       1100       1110       1120       1130       1140 
REVEETVARL AALRELDAAA PGDEPAPPAA LPSPAKRPRE TPSPADPPGG ASKPRKLLVS 

      1150       1160       1170       1180       1190       1200 
ELAEDPAYAI AHGVALNTDY YFSHLLGAAC VTFKALFGNN AKITESLLKR FIPEVWHPPD 

      1210       1220       1230 
DVAARLRTAG FGAVGAGATA EETRRMLHRA FDTLA
P04293 in FASTA format

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