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HAMAP: Francisella tularensis subsp. holarctica (strain LVS) complete proteome

General information

Species:  Francisella tularensis subsp. holarctica (strain LVS)
Species code: FRATH
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales; Francisellaceae; Francisella (TaxID: 376619) [NEWT/ NCBI]
Description: Francisella tularensis is a rod-shaped Gram-negative bacterium and is the causative agent of tularemia. Tularemia can affect both humans and animals. The subspecies tularensis (Type A) and holarctica (Type B) are the ones most commonly associated with the human disease. Its natural hosts are rabbits, hares, beavers and other rodents, as well as flies and mosquitos. The disease can be transmitted by different ways: through scratches or bites from animals, through consumption of contaminated meat or water or through inhalation of bacteria. The symptoms developed by infected people directly reflect the mode of transmission: pneumonia-like illness for the airborne transmission; throat infection, stomach pain, diarrhea and vomiting for the gastrointestinal transmission; apparition of a sore at the entry point of the bacteria and swelling of the draining lymph nodes for transmission via skin wounds. Tularemia can be treated with antibiotics, but without therapy the mortality rate of respiratory tularemia can be as high as 5-30%. F.tularensis is very infectious and ten cells are sufficient to cause infection in humans. The bacterium can survive for weeks at low temperatures in water, soil or animal carcasses. During World War II, the use of F.tularensis as a biological weapon was studied by Japan, Soviet Union and USA.
Francisella tularensis subsp. holarctica (strain LVS) is a type B strain. The LVS strain was originally isolated in the former Soviet Union from a water rat and transferred from the Gamaleya Institute, Moscow, Russia to the U.S. Army Medical Research Institute of Infectious diseases (USAMRIID) in 1956. It is an attenuated strain that has been used to make a live vaccine. This vaccine is not licensed for use in the USA.
Properties: Presence of flagella: No
Human pathogen: No
Interaction: Animal pathogen in Mammalia; Avirulent strain
Number of membranes: 2
Number of inteins:0
Statistics: Number of FRATH entries in the UniProt Knowledgebase: 1678 (286 in UniProtKB/Swiss-Prot + 1392 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    LVS
Genome structure:
Chromosome EMBL accession number AM233362 (circular; 1,895,994 bp) (download entry) (download Genome Reviews).
Reference(s):
[1] Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S., Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R., Garcia E. ;
"Complete genome sequence of Francisella tularensis LVS (Live Vaccine Strain).";
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
Web links:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Francisella&GLspecies=tularensis&GLsupStrain=LVS
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid376619%5Borgn%5D
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Ftul_LVS
PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=start_method&Db=p3_p16421_Fra_tular
 EBI Proteome Analysis page



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