PROSITE entry PS51924

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51924
Entry name [info]	COV_S2_HR2
Accession [info]	PS51924
Entry type [info]	MATRIX
Date [info]	17-JUN-2020 CREATED; 07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51923
Associated ProRule [info]	PRU01272

Name and characterization of the entry

Description [info]

Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=82;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=77;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.8437381; R2=0.0062844; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=13910.6914062; R2=4.1364145; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1378; H_SCORE=19611; N_SCORE=11.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=582; H_SCORE=16318; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-35; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P';  M= -64, -84,   4, -56, -76, -68, -67,   1, -62, -16, -63,  13, 110, -64, -73, -14,  -8, -66, -81, -75;
/M: SY='D';  M=  24, -73,  53,  29, -81, -59, -57, -75, -53, -76, -69,   2,  34,  42, -59,  47,  -6, -70, -83, -70;
/M: SY='Y';  M= -65, -72,   4, -64,  43, -73, -54, -49, -64,  39, -47,  33, -77,  19, -65, -14,   6, -16, -56,  71;
/M: SY='P';  M= -65, -78, -10, -64,  46, -76, -67,  44,  -9,  -9, -51, -68,  72,   1, -68, -15, -59,   5, -65,  19;
/M: SY='D';  M= -61, -76,  89, -44, -83,  19, -53, -82, -55, -84, -77,  67,  15, -54, -63,  14, -53, -80, -93, -72;
/M: SY='F';  M= -66, -71, -78, -79,  91, -15, -71,  48, -74, -42, -48,  12, -79, -78, -75, -66,  -9,  28, -57, -36;
/M: SY='N';  M= -62, -75,  64,  41, -75, -14, -50, -76,  -9, -75,  13,  76, -67,  18, -56, -51,  -8, -75, -84,   3;
/M: SY='E';  M=  21, -75,  27,  55,  11, -16,  17, -75,  44, -71, -66, -52, -63,  33, -48, -52,   6, -69, -75, -61;
/M: SY='E';  M= -59, -75,  31,  86, -79, -72, -58, -75, -48, -73, -70, -52,  19, -44, -58, -50,  63, -68, -84, -71;
/M: SY='F';  M= -70, -73, -82, -74,  94, -82, -68,  14, -73,  37, -43, -76,   6,  19, -72, -72, -64, -13, -54, -34;
/M: SY='D';  M= -14, -76,  66,  47, -82, -63, -52, -80,  13, -78, -71,  47, -65,  38,   9,  10, -55, -76, -85, -69;
/M: SY='E';  M= -61, -79,  52,  80, -80,  -4, -55, -80,  43, -31, -70,   5, -61, -42, -48, -56, -59, -76, -82, -70;
/M: SY='W';  M= -67, -78,   8, -73,  20, -81, -67,  56, -73,  25,  22, -74, -78, -70, -73, -72, -64,   2,  94,  59;
/M: SY='F';  M=  -4, -75, -81, -77,  81, -79, -62,  30, -70,   6,  10, -75, -80, -72, -12, -69, -65, -48,  59,  65;
/M: SY='K';  M= -21, -74,  31,  18, -77, -11, -58, -68,  49, -72, -65,  12, -65,  37,  10,   7,  24,   1, -81, -67;
/M: SY='N';  M= -59, -71, -43,  24,   1,  17, -50, -76,  -4, -77, -68,  97, -69,  10, -13,  -9,  -9, -75, -82, -66;
/M: SY='Q';  M= -63, -74, -72, -63, -51, -78,  43,  27, -64,  44,  34, -66, -74,  56, -64, -62,  22,   1,  50,  11;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='N';  M= -55, -69, -47, -53, -75, -56,  28, -73,  20, -77, -66,  83,  -2,  17, -53,  51,  34, -70, -87, -66;
/M: SY='H';  M= -60, -73, -59, -59, -55, -66,  51, -63,  -7,   6,  15,  44, -71,  17,  19,  30,  21, -64,  48,  50;
/M: SY='T';  M=   3, -68,   6,  24,   7, -67, -63, -12, -58, -11,  16,   8, -66,   3, -64,  16,  58,  14, -79, -60;
/M: SY='N';  M=  15, -69, -63, -15,  27,   5, -64,  -7,  14,  28, -51,  29, -71, -60, -62,   2,  25, -11, -73, -57;
/M: SY='P';  M= -62, -80,   5,  33, -70, -71, -63,  -3, -58,  11,  12,  -3,  86,  19, -66,  -6, -57, -18, -79, -69;
/M: SY='Q';  M=  -9, -72, -47,  47, -77, -62, -54, -67, -49, -71, -64,  56,  -1,  66, -55,  28,  25,  -6, -82, -68;
/M: SY='L';  M= -66, -70, -81, -74,  58, -82, -68,  20, -74,  69, -36, -75, -80,   0, -73, -17, -10, -42, -64, -44;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='K';  M= -70, -85, -73,  -8,  17, -18, -73, -14,  45,   6, -65, -68, -80,  21, -60,  22, -67, -70,  41, -64; D=-38;
/I:         I=-38; DM=-97;
/M: SY='D';  M= -58, -71,  76,  -6, -79, -57, -52, -78,  -5, -80, -73,  74, -67, -50, -58,  41,  16, -74, -93, -69;
/M: SY='I';  M= -20, -72, -71,  19,  30, -23, -71,  48, -67,  27, -43, -70, -74,  14, -70, -64, -11,  40, -71, -54;
/M: SY='F';  M= -19, -70, -64, -65,  63, -19, -60,  -9,   3, -24, -57,  26,  -3, -61, -63,  44,  23, -58, -61,  33;
/I:         I=-33; MD=-84;
/M: SY='N';  M=   7,  25,   9, -73,  24, -22, -73, -21, -74, -81, -78,  48,  -8, -73, -80,  27, -65, -76, -90, -73; D=-33;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='N';  M= -59, -67,  33, -53, -76, -54, -48, -74, -50, -79, -69, 108, -69, -52, -59,   5,  41, -72, -95, -70;
/M: SY='M';  M=  35, -71, -72, -65,  39, -70,  23,  22, -66,  16,  61,  -4,   6,  26, -67, -60, -59,  -3, -70, -51;
/M: SY='T';  M= -51, -68, -53,  24, -75, -60, -61, -69, -55, -73, -67,   9,  51, -53, -63,  66,  68, -64, -84, -69;
/M: SY='Y';  M= -64, -74, -74, -73,  24, -80, -59,  44,  -1,   5,  26,  -1, -78, -66, -66, -67, -59,  35, -54,  81;
/M: SY='L';  M= -64, -68, -80, -76,   9, -83, -69, -31, -75,  79, -33,   0, -83, -71, -74, -73, -60,  35, -72, -53;
/M: SY='N';  M= -64, -71,  69, -48, -74, -55, -46, -77, -51, -81, -72, 105, -71, -52, -59, -47,  -1, -77, -91,   3;
/M: SY='L';  M= -66, -71, -85, -79,  26, -87, -73,  44, -78,  73, -32, -81, -82, -74, -77, -75, -61,  13, -69, -50;
/M: SY='T';  M= -52, -67, -55, -56, -63, -61, -57, -16,  19, -67, -62,  31, -65,  15, -55,  58,  69, -59, -74,  34;
/M: SY='D';  M=   7, -74,  39,  37,  -9,  10, -55, -70,  10, -70, -65,  37, -67,  17, -56, -11,  -4, -21, -72,  35;
/M: SY='E';  M= -61, -82, -39,  93, -71, -74,  38, -79, -44, -72, -65, -55, -60,  65, -50, -56, -62, -76, -70,  38;
/M: SY='M';  M= -60, -71, -76, -75, -52, -79, -70,  73, -71,  13,  77,   5, -73, -67, -73, -10,   9,  18, -77, -57;
/M: SY='N';  M=  47,  32,  49,  39, -78, -60, -56, -73, -52, -32, -66,  50, -67,  44, -59, -49, -55, -67, -84, -70;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='E';  M= -10, -73,   7,  48, -64, -72,  17, -13, -15,  26, -53,  32, -69, -51,  34, -58,  -9,   8, -81, -63;
/M: SY='L';  M= -66, -72, -84, -79,  16, -87, -71,  60, -77,  66, -33, -80, -81, -73, -76, -75, -61,   0, -66,  18;
/M: SY='Q';  M= -58, -76,  43,  -1, -82, -62, -50, -77,   7, -76, -66,  56, -67,  86,   1,  24,  -7, -75, -82, -66;
/M: SY='N';  M= -57, -73,  54,  45, -76,   9, -54, -75,  -5, -14, -68,  57, -66, -48, -58,  43, -51, -72, -85, -69;
/M: SY='I';  M= -10, -71, -77, -72,   7, -78, -69,  55, -70,  29, -41, -70, -75,   7, -72, -14,   9,  38, -68,  31;
/M: SY='I';  M=  34, -70, -73, -72, -58, -70, -75,  78, -70, -44, -45,   3, -71, -66, -74,  26, -52,  28, -78, -62;
/M: SY='H';  M= -62, -78,  48,  35, -73, -67,  62, -78,  31, -74, -65,  24, -66,  54,  -4, -13,  -1, -76, -79,  14;
/M: SY='N';  M= -55, -72, -46,  25, -80,  14, -52, -78,  29, -79, -68,  75, -66,  53, -49,  44, -50, -75, -81, -69;
/M: SY='L';  M= -63, -71, -85, -79, -46, -87, -77,  59, -78,  63, -33, -80, -80, -74, -77, -74, -59,  45, -75, -56;
/M: SY='N';  M= -60, -68, -41, -56, -73, -53, -47, -71,  23, -17, -65, 110, -71, -49, -52,  23, -47, -73, -89, -69;
/M: SY='N';  M= -24, -74,  41,  20, -81,  15, -53, -79,  34, -79, -69,  57, -66,  52, -50,  26, -53, -76, -82, -69;
/M: SY='T';  M= -53, -67,   4, -60, -60, -63, -59, -57, -60,   1,  61, -52,   8, -57, -65,  62,  62, -56, -76,  22;
/M: SY='Y';  M= -67, -72, -68, -70,  44, -76,  26,  -2, -63,  42, -44,  34, -79, -64,   5, -64,   6, -14, -58,  63;
/M: SY='I';  M= -59, -71, -80, -78, -52, -84, -81,  74, -75,  -3, -39,   6, -77, -74, -77, -68, -54,  72, -81, -59;
/M: SY='D';  M= -64, -75,  97,  23, -82, -62, -52, -80, -52, -81, -76,  59, -66, -51, -61, -50,  27, -76, -97, -70;
/M: SY='L';  M= -63, -69, -81, -74, -45, -83, -71, -32, -75,  78, -33, -79,   6, -71, -75, -71,   1,  36, -75, -56;
/M: SY='E';  M= -58, -76, -43,  80,   4, -69,  31, -78,  47, -73, -67, -52, -61,   8, -45,  35, -55, -73, -76, -62;
/M: SY='W';  M= -65, -85, -55,  66, -62, -74, -65,  -7,  25, -30, -64, -64, -66,  54, -52, -63, -67, -71, 126, -51;
/M: SY='L';  M= -67, -69, -80, -76,  53, -82, -67,  -4, -75,  71,  36,   6, -82, -71, -73, -73, -62,  -3, -65, -45;
/M: SY='N';  M= -57, -72, -50, -57,   9,  48, -55, -77,  38, -77, -68,  80, -69,  20, -53,  16, -54, -76, -77, -65;
/M: SY='R';  M= -61, -76, -61, -51, -72, -74, -59,  -6,  53, -66, -59, -53, -68,  24,  78, -54,  45,  -8, -77, -63;
/M: SY='Y';  M= -65, -75, -74, -75,  39, -14, -51,  -4, -69, -11, -48, -71, -80, -67, -68, -64,   1,  30, -42, 106;
/M: SY='E';  M= -57, -75, -44,  85, -74, -76, -59, -59, -46, -65, -62, -57, -61,  17,   8, -54,  40,  33, -82, -68;
/M: SY='T';  M= -59, -72, -58, -54, -62, -70, -55, -59,   7, -17,  16,  31, -69,  60,  37, -50,  61,  -4, -73,  30;
/M: SY='Y';  M= -70, -81, -68, -68,  12, -77,  32, -58, -63, -54, -51, -67, -80,  15, -61, -63, -11, -63, -33, 125;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='V';  M= -56, -71, -75, -16, -56, -79, -78,  63, -71, -16, -44, -71,  10, -69, -75,  19, -52,  69, -81, -61;
/M: SY='K';  M= -62, -76, -53, -42, -79, -67, -57, -79, 106, -78, -66,  13, -63, -40, -26, -14, -55, -75, -74, -66;
/M: SY='W';  M= -74, -98, -99, -79, -42, -73,-100, -72, -71, -71, -73, -91, -78, -71, -75, -78,  -2, -85, 176, -28;
/M: SY='P';  M=  -8, -89, -67, -56, -85, -67, -70, -73, -63, -83, -70, -72, 125, -66, -75, -62, -58, -77, -79, -83;
/M: SY='W';  M= -76,-101,-103, -80, -40, -74,-103, -73, -72, -71, -74, -96, -79, -72, -76, -82, -88, -88, 179, -27;
/M: SY='W';  M= -71, -87, -78, -76, -27, -14, -51, -63, -68, -60, -57, -77, -81, -64, -67, -70, -72, -70, 132, 114;
/M: SY='V';  M=  -8, -69, -80, -72, -56, -81, -81,  42, -71, -41, -43, -75, -76,  17, -73, -64, -53,  89, -83, -61;
/M: SY='W';  M= -76,-101,-103, -80, -40, -74,-103, -73, -72, -71, -74, -96, -79, -72, -76, -82, -88, -88, 179, -27;
/M: SY='L';  M= -66, -69, -84, -77, -41, -86, -69, -31, -78,  90, -29, -84, -84, -71, -75, -77, -62,  -6, -72, -54;
/M: SY='A';  M=  53, -69, -74, -71, -59,  32, -73,  51, -70,  30, -47, -66, -71, -67, -74, -55, -15, -42, -74, -64;
/M: SY='I';  M= -65, -76, -86, -83,  21, -88, -79,  99, -77, -32,  62, -75, -74, -74, -79, -73, -59, -23, -70, -51;
/I:         I=-45; MD=-115;
/M: SY='F';  M=  31, -76,   1, -74,  55,   7, -77, -21, -76, -65, -66, -68, -81, -74, -79,  27, -62,  14, -75, -58; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='I';  M= -65, -73, -86, -81,  47, -86, -76,  74, -77,  35,  38, -78, -78, -75, -78, -73, -60,  24, -67, -47;
/M: SY='A';  M=  68,  27, -73, -67, -63, -62, -73,  -5, -67,   3, -51, -66, -72, -65, -71,  -6,  -9,  47, -80, -66;
/M: SY='W';  M= -63,  57, -79, -77,  51,  31, -71, -10, -74,  47,  21, -70, -79, -73, -75, -66,   1, -52,  62, -48;
/M: SY='I';  M= -16,  20, -79, -76, -50, -82, -76,  70, -74,  47, -37, -72, -75, -71, -76, -65,  31,   8, -76, -58;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.

Total number of hits	50 in 50 different sequences
Number of true positive hits	50 in 50 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	REGION
Feature description [info]	Heptad repeat 2 (HR2)
Version [info]	2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

50 sequences

SPIKE_BC133 (Q0Q4F2), SPIKE_BC279 (Q0Q475), SPIKE_BC512 (Q0Q466),

SPIKE_BCHK3 (Q3LZX1), SPIKE_BCHK4 (A3EX94), SPIKE_BCHK5 (A3EXD0), 
SPIKE_BCHK9 (A3EXG6), SPIKE_BCRP3 (Q3I5J5), SPIKE_CVBEN (Q91A26), 
SPIKE_CVBF  (P25190), SPIKE_CVBL9 (P25191), SPIKE_CVBLS (Q9QAR5), 
SPIKE_CVBLU (Q8V436), SPIKE_CVBLY (P25192), SPIKE_CVBM  (P15777), 
SPIKE_CVBOK (Q9QAQ8), SPIKE_CVBQ  (P25193), SPIKE_CVBV  (P25194), 
SPIKE_CVCAI (P36300), SPIKE_CVCAK (Q65984), SPIKE_CVCBG (Q7T6T3), 
SPIKE_CVH22 (P15423), SPIKE_CVHN1 (Q5MQD0), SPIKE_CVHN2 (Q14EB0), 
SPIKE_CVHN5 (Q0ZME7), SPIKE_CVHNL (Q6Q1S2), SPIKE_CVHOC (P36334), 
SPIKE_CVM4  (P22432), SPIKE_CVMA5 (P11224), SPIKE_CVMJC (Q02385), 
SPIKE_CVMJH (P11225), SPIKE_CVP67 (Q8BB25), SPIKE_CVPFS (P18450), 
SPIKE_CVPIA (Q8JSP8), SPIKE_CVPMI (P33470), SPIKE_CVPPU (P07946), 
SPIKE_CVPR8 (P27655), SPIKE_CVPRM (P24413), SPIKE_CVPRT (Q01977), 
SPIKE_CVRSD (Q9IKD1), SPIKE_FIPV  (P10033), SPIKE_IBV6  (P05135), 
SPIKE_IBVB  (P11223), SPIKE_IBVD2 (P12722), SPIKE_IBVK  (P12650), 
SPIKE_IBVM  (P12651), SPIKE_MERS1 (K9N5Q8), SPIKE_PEDV7 (Q91AV1), 
SPIKE_SARS  (P59594), SPIKE_SARS2 (P0DTC2)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

1134 PDB

1WDF; 1WDG; 1WNC; 1WYY; 1ZV7; 1ZV8; 1ZVA; 2BEQ; 2BEZ; 2FXP; 2IEQ; 2RUN;
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