PROSITE entry PS51547

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51547
Entry name [info]	C2_PI3K
Accession [info]	PS51547
Entry type [info]	MATRIX
Date [info]	01-AUG-2011 CREATED; 26-FEB-2020 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51547
Associated ProRule [info]	PRU00880

Name and characterization of the entry

Description [info]

C2 phosphatidylinositol 3-kinase (PI3K)-type domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=155;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=150;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9253478; R2=0.0079611; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=28608.4277344; R2=5.6183205; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1015; H_SCORE=34311; N_SCORE=10.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=575; H_SCORE=31839; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-34; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='I';  M= -26,  36,-133, -23,  12,  -4, -25,  41, -43,  32,  -1, -41, -52,-127,-131,  -3,  -8,  34,   9, -26;
/M: SY='D';  M= -57, -52,  38,  35, -38, -24,  13, -85,  18, -78,  -5,  32,   5,  23, -49,  37,  24, -87,-139,  -7;
/M: SY='E';  M=  11, -20,  30,  38, -71, -29, -39, -14,  16, -99,-124, -31, -19,  29,  32,  25,  16, -37,-140,-126;
/M: SY='P';  M= -15,  19, -10, -29, -49, -55,  -7, -42,  43, -20,   0,  44,  46, -11,   4, -30,  19, -31, -24,   3;
/M: SY='F';  M= -61,-130, -77, -34,  75,-139, -28, -36, -89,  51,  33, -29, -49, -38, -71, -29, -22,  16, -34,   7;
/M: SY='S';  M= -60,  24,   1, -12, -67, -28, -12, -50,   9,  -3,  21, -64, -62,  29,  43,  47,  15,  -9,-139, -50;
/M: SY='I';  M= -45, -23,  26, -24,  14,-136,-128,  54, -83,   8,  26,  -8,  -2,   1, -72, -12, -79,  43,-136, -49;
/M: SY='P';  M= -36,  11, -17,  15, -41,-129,  16, -81,  27, -15, -22, -10,  61,   7,  45,   0,  10, -70,-137, -24;
/M: SY='I';  M=  -6, -52, -92,-130,  -7, -63, -45,  63, -26,  18, -27, -45,  -3,  -9,-130,   8, -73,  45,-133, -13;
/M: SY='L';  M= -43,  -1, -46, -26, -50,  12,  -4,  24,   1,  28,  -1,  18, -22,  11,   7,  -2, -52,  15, -38, -34;
/M: SY='S';  M=   4,  27, -75, -12,   0,  18, -21,-129,   7, -19,-123,   7, -62,  17,   2,  61, -15, -82,  29, -33;
/M: SY='L';  M=   6, -49, -30, -18,  18, -18,  -1,  35, -61,  37, -18, -40, -72,  14, -22,  -6, -71,  17,-131,  -4;
/M: SY='H';  M= -24,  -7,  14,  45, -72, -22,  78, -27,  16,-129,-122, -37, -41,  16, -75,  21,  32, -49,-139,   9;
/I:         I=-14; MD=-36;
/M: SY='N';  M= -41,-140, -32,  -3,-141,  39,  13, -46, -86, -57, -23,  67, -50, -18,  30,  20,-122, -87,-148, -78; D=-14;
/I:         I=-14; MD=-36;
/M: SY='I';  M= -36, -43, -43, -50,  -6, -96,-146,  31, -78,  22,-122, -42,  11,-142, -30,   1, -76,   2,-150, -63; D=-14;
/I:         I=-14; MI=0; MD=-36; IM=0; DM=-36;
/M: SY='H';  M= -67,  -2, -33,   7, -37, -22,  30, -36, -33,  -2, -57,  12,  12, -20, -37,   4,  -9, -32,-146,  18; D=-14;
/I:         I=-14; DM=-36;
/M: SY='S';  M= -54, -11, -61, -42,  11, -35,   4, -28, -28,  18, -36,   6,   1,  24, -18,  31, -13,   5,-137,   8; D=-14;
/I:         I=-14; DM=-36;
/M: SY='W';  M= -44, -58,   4, -46,   7, -54,  12,  -5,  -3, -26, -54,  51,  25,   8,  -2,   2, -15, -34,  64,  15; D=-14;
/I:         I=-14; DM=-36;
/M: SY='Q';  M= -21,  -7,  17, -30, -18, -34,  23, -17, -21, -38,  18,   5,   0,  33,  -8,  20,  -6,  15, -32,  28; D=-14;
/I:         I=-14; DM=-36;
/M: SY='S';  M=  -8, -44,  27, -43, -13,  -5, -18, -41, -30, -11,   6, -19,  -3,  17,  -4,  45,   0, -12,  43,  -5; D=-14;
/I:         I=-14; DM=-36;
/M: SY='T';  M= -14, -16,  15,   7, -60, -19, -20, -21,  19, -32,-122,  28,  19, -37,  18,  28,  37, -17,-141, -63;
/M: SY='H';  M= -31, -28,  29, -15,  23, -30,  39, -11,  -9, -14,-117,  32,  29, -15, -13, -14,  16, -21,-131,  32;
/M: SY='S';  M= -69,   2,  23,   9,   8, -26,  -1, -10, -25, -10, -16,  12,  19,  -6, -29,  42,  12, -12,-134,  11;
/M: SY='D';  M= -45,-136,  45,  37, -42, -68, -50, -21,  10, -10,   1,   6,  34, -20, -13,  28, -24, -62,-133,  32;
/M: SY='F';  M= -61,  18, -77,-136,  48,-141, -16,  47,-134,  45,  28, -72,-139, -63,-133, -37,-119,  31,-124,  36;
/M: SY='Y';  M= -31,  14,-128, -56,  48, -11, -12, -12, -44, -45, -47, -20, -68, -17,   4,  24, -17,  -2,  23,  84;
/M: SY='V';  M= -30,  13,-141, -79, -38,-142,-139,  47,-133,   4,  22,-135, -39, -40, -78,-126, -42,  85,-141,-119;
/M: SY='T';  M= -25, -30, -37,  47,-131, -50, -55, -43,  -2, -23, -33, -38, -25,  25,  31,  35,  54, -32,-139, -57;
/M: SY='C';  M=  52,  80, -69,-131,  -3, -28,-133,  21,-129, -12, -60, -43,-135,-129, -75, -41, -30,  48,-137, -22;
/M: SY='Q';  M=   2,  16, -32,  30, -71,  24, -46,-132, -52, -95, -25, -43, -72,  86,  -7,  33, -23, -33, -23, -35;
/M: SY='L';  M= -57,-131,-143,-137,-107,-144,-135,  63,-136,  66,  -4, -73, -74, -57,-136, -52,-118,  44,-135,-116;
/M: SY='Y';  M=-127,  11,-135, -77,  63, -87,   3,  13,-128, -17,  16,-130, -71,-127, -48, -59,   8, -16,  46, 100;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='H';  M=   8,  26,  11, -53, -45,-126,  98, -84,-118, -62, -22, -26, -63,  -4,  -4,  35,-117, -23,-128,  71;
/M: SY='G';  M= -46, -18,  20,  -5,-138,  86,-122, -83, -71, -92,  -4,  42, -56,-119, -14, -18,-121,-137,-137, -36;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='G';  M= -61, -23,  29,  18,-138,  57,-119, -60, -36,-138,-130,  53, -69, -20, -73,  37,  36,-131,-143,-131;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='K';  M= -49, -66, -48,  23,-130, -50, -13, -56,  52, -30, -29,  30, -36,  47,  39,   0,   6, -35, -15,   0;
/M: SY='P';  M= -15, -44, -34,  -8, -30, -64,-124, -49, -11,  30, -60, -14,  78,  13, -17,   7,   3,  -8,-137,-125;
/M: SY='L';  M=-125,   9, -70,-135, -17, -66, -48,  44, -56,  77,  24,-136,-140, -66, -72, -69, -71,  -7,-131, -39;
/M: SY='C';  M=  20,  84, -30, -70, -27,  17,  32, -19,-123, -91,-123, -56, -62, -60, -71,  50,  48, -32, -26,-125;
/M: SY='P';  M= -67, -18,   5,  -2, -77, -41, -19, -23,  32,  -4, -51,  36,  51,  14, -17,  16,  -3,  -2,-138, -15;
/M: SY='P';  M= -30,   9,-122,  -1, -41, -22, -20, -16, -14, -68,  -6, -25,  92,  -1, -37,  13,  16,  -4, -26,-129;
/M: SY='V';  M= -30, -21, -52,   1, -10, -46,-125,  11,   8, -12,  43, -76,-132,  14,  21,   9, -16,  52,-134,  -8;
/M: SY='Q';  M= -63,   0, -62,   4,  -3, -89,  -6,   8,   2, -30,   8,   1, -35,  48,   5,  30,  42, -12,-133,  16;
/M: SY='T';  M= -17, -16, -44, -36, -17,-124,-125, -25, -19, -58,-121,-110,   3,-117, -27,  55,  93,-115,-142,-124;
/M: SY='S';  M= -11, -38, -57, -11,   8, -42, -20, -44,  29,-129,-123, -13,  40,  25,  10,  57,  20, -34, -31, -58;
/M: SY='Y';  M= -24,   1, -48, -20, -26,-131,  31, -34,  22, -16, -52, -61,  36,  10, -29,  11, -16,  26,  45,  61;
/I:         I=-28; MD=-70;
/M: SY='K';  M=  -9,  -3, -29, -70, -26, -89, -45,   7,  35, -66, -53, -40, -11,  32, -26,  32,  24,  30,-138,  -5; D=-28;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='P';  M=  32,-133,   2, -44,-133,-120, -59, -32, -13, -51,-123,  30,  75,   9, -72,  42, -21, -14,-139, -28;
/M: SY='F';  M= -17, -15, -84, -83,  75,  -1,  17,  33, -79, -10,  -9,-126,   5,  -7,-130,  18, -66,   8,-122,   1;
/I:         I=-13; MD=-32;
/M: SY='S';  M= -14,   4, -30,   1, -47, -44,  -7, -40,  27,-134,-127,  34, -19,   4,  11,  60,  18, -92,-141, -32; D=-13;
/I:         I=-13; MD=-32;
/M: SY='N';  M= -27,  -6,  26,  -3, -79, -51,  12, -68,   0, -93, -21,  75,  -2, -63,  15,  12,  14, -47,-146, -15; D=-13;
/I:         I=-13; MD=-32;
/M: SY='S';  M= -60, -46, -12,   2, -56,  14,   3, -15,  -7, -94, -63,  44, -24, -68, -27,  44,  11, -83, -29, -37; D=-13;
/I:         I=-13; MD=-32;
/M: SY='F';  M= -76,-162, -21,-146,  30, -76,  20, -90,  -9, -22, -29, -76,   0, -35,  -3,  -6, -79, -50,-156, -57; D=-13;
/I:         I=-13; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='W';  M= -15,  24, -75, -53,   2, -49,   0,  32, -74,  18,-111, -42,  48, -17,  36, -45, -36,   6,  73, -49;
/M: SY='W';  M= -40,-133,   0,  23, -10, -81, -51, -11,  17, -12, -43,  20, -18,   0,  16,  23,  25,  11,  52, -59;
/M: SY='W';  M= -83, -41, -27, -74,  49,-134, -16, -37, -38, -47,-124, -47, -60,-129, -28, -38, -38, -47, 162, -45;
/M: SY='N';  M= -85, -54,  71, -24,-136, -18,  23,-135, -27, -52,-129,  94, -11, -58, -27, -18, -34, -62,-150, -38;
/M: SY='E';  M= -59, -20, -20,  90, -64, -49,  13, -27, -37, -60,-124, -26,-122,  56, -33, -23,  -9, -21, -14, -60;
/M: SY='W';  M= -46,-142, -17, -20, -34, -90,-131, -77,  20, -48, -22, -59, -42,  20, -28,   3,  16, -36, 147,   7;
/M: SY='I';  M= -65,-131,-142,-137,  -2,-144, -13,  66,-136,  63,  24,-137, -80,-131,-136, -39, -81,  25,-132, -55;
/M: SY='T';  M= -50, -19,   3,  38, -38,-128, -17,   2,  13, -48, -11,  23, -45,   3, -27,  15,  60, -18,-138,   1;
/M: SY='F';  M=-130,-131,-144,-140, 112, -44,-127, -50,-137,  37,  -6,-135,-143,-140,-135, -39, -33, -81,-109, -38;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='P';  M= -64, -54,  61, -44,-143, -15, -48, -73, -74,-142,-132,  50,  97, -29, -21,  -8, -76,-137,-146,-135;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='I';  M= -70,-133,-142,-138,  -7,-144,-137,  84, -74,  28,   7, -74,-137, -37,-136, -37, -39,  39,-133, -25; D=-38;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='K';  M= -15,-135,   9, -21, -45,-127, -22,-126,  44,   5,-119,  24,  28,  23,  30,  16,  -8, -77,-131,  33;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='Y';  M= -74,-134,-140,-137,   0,-143, -47,  69,-133,  23,  29,-135, -65,-130,-133,-129, -35,  31,-117,  81;
/M: SY='C';  M= -30,  78,-119, -75,-133,-122, -39, -73,  33, -85, -21,  32, -22,  -9,  43,  68,-110, -30,-142,-127;
/M: SY='D';  M= -19, -54,  83,  21, -67,-123,  -1, -59,-111,-101, -30,  42,-127,  65, -62,   4,  -9, -37,-147,-126;
/M: SY='L';  M= -48,-130,-144,-137, -16,-145,-131,  42,-137,  83,   9,-141,-141,-131,-136,-134,-121,   1,-131, -56;
/M: SY='P';  M= -65,-145, -29,-115,-142, -90,-127,-133,-122,-103,-130, -70, 124,-123,-132,  31, -33,-135,-139, -53;
/M: SY='R';  M= -31,   8, -64, -78, -42,-134,  15, -32,  14,  29,  -8,-120,   0,  -6,  86, -17, -75, -80,-134, -33;
/M: SY='E';  M=  -5,-134,  62,  72,-138, -16,-114,-135,-110,-134,  17,  48,-123,-107, -52,  16,   0, -79,-145, -52;
/M: SY='A';  M=  71,  38,-123,-121,-130, -78,-125, -75,-121, -68, -40, -34,-126,-118,-126,  59,  49, -59,-139, -19;
/M: SY='R';  M= -80,  -1,-126, -51,  -4, -80,-118,   7,  21, -31,  31,-119,-132,  48,  80, -64,   2,  -6,  -5,   3;
/M: SY='L';  M= -55, -41,-144, -75,   0,-145,-132,  54,-137,  78,   3,-140,-140,-132,-136,-134,-121,   2,-131,-113;
/M: SY='C';  M=  14, 100, -44,  -7, -69, -50,  20, -26, -15, -23, -17, -42,-134, -16, -10,   7,   5,  25,-142, -17;
/M: SY='F';  M= -54,  14,-143,-139,  78,-143,-133,  59,-136,  40, -18,-136,-140,-137,-136,-130,  -8,  13,-122, -45;
/M: SY='T';  M=  10,  -2, -73, -36,-129, -84, -20, -53,   5, -54, -21,  -4,-125, -11,  -3,  47,  74,  13,-143,-125;
/M: SY='I';  M= -65,-130,-144,-138, -15,-146,-137,  64, -76,  60, -95,-139,-139,-134,-136,-132,-118,  58,-134,-115;
/M: SY='W';  M=-128,   6, -70, -71,  52,-138,   1, -10, -75,  -2,-111, -70,-140,-127,  -7, -41,-125,   7, 109,  92;
/M: SY='D';  M=  28,  11,  47,  37, -66,  42, -42, -28, -46, -72,   2, -22,-127, -33, -43,  21,-116, -40, -15, -32;
/M: SY='Y';  M=  -7,  -1,-127, -47, -31, -49,  25,  16,   8,  -6,  -7,  -6, -11,-121,  -4, -24,  36,  39,-132,  39;
/M: SY='D';  M= -16,  -6,  30,   0, -79, -47,  14, -64,  25, -38, -47,  18,  -2,   4,  23,  29,  14, -14,  13,   9;
/M: SY='K';  M=  -6, -23,  28,   2, -15,  15, -38, -65,  29, -30, -25,  -4,  19,   1,   7,  16,  10, -16, -26, -68;
/I:         I=-4; MD=-11;
/M: SY='N';  M=   0, -14,  27,  -7, -70, -25, -56, -18,  11, -38, -57,  29,  18,  26, -39,  24,  16, -10,-144,-129; D=-4;
/I:         I=-4; MD=-11;
/M: SY='S';  M=   8,-138, -47, -30,-138,  10,-129, -59,   7, -29,-127, -39,  31,  -3,  13,  33,  30, -21,-144, -61; D=-4;
/I:         I=-4; MD=-11;
/M: SY='K';  M= -28,-147,   3,   4, -43,   7, -47, -41,  32, -73,  -6,   1, -23, -26,  25,  -8, -16, -67,-149, -61; D=-4;
/I:         I=-4; MD=-11;
/M: SY='T';  M=  -8, -45,  16, -26, -90,   3, -45, -58, -38, -63, -23, -36,-149, -38, -42,   6,  21, -45,-161, -32; D=-4;
/I:         I=-4; MD=-11;
/M: SY='G';  M= -28,-159, -40, -49,-161,   8, -11,-153,  -6,-112, -11,  -7, -82,  -4, -29,  -4,   5, -27,-168,-154; D=-4;
/I:         I=-4; MI=0; MD=-11; IM=0; DM=-11;
/M: SY='N';  M= -40, -38, -46, -14, -25, -32, -12, -40,  14, -29, -58,  16, -42,-140, -50, -19, -37, -62,-160, -16; D=-4;
/I:         I=-4; DM=-11;
/M: SY='E';  M= -33, -50,  13,  36, -56, -64,  15,-151,  11,-151,-144,  20,  11, -31, -74, -15,   4, -59,-159, -74; D=-4;
/I:         I=-4; DM=-11;
/M: SY='E';  M= -21, -54,  14,  35,-139, -63,  20, -12, -19, -79, -50, -29,  23, -23,   8,  18, -16, -32,   4, -10; D=-4;
/I:         I=-4; DM=-11;
/M: SY='V';  M= -67, -15, -34,  10,  -4, -84,  -8,  21,  -3, -51, -14,  16, -36,  30,   5, -56,  31,  34,-141, -31; D=-4;
/I:         I=-4; DM=-11;
/M: SY='P';  M= -26,  10,-128,  13,  10, -91,-127,  17, -15,  27,   1, -64,  72, -32, -30, -74, -22,  17,-133, -28;
/M: SY='I';  M=-124,-132,-143, -72,  23,-146, -44,  66, -69,  55, -15,-138, -55,-133,-135,-132,-119,  42,-129,  -8;
/M: SY='G';  M=  49, -26, -60,-130, -75,  90,-129,-137, -76, -32,-127, -50, -59,-124,-133, -51,-122,-130,-133, -39;
/M: SY='W';  M= -76,  12, -78, -40, -31,  24,  21, -63, -28,-126, -48,-124,-132,   8, -28,  14,  16,   3, 138,  12;
/M: SY='T';  M=  33,  15,-127, -69, -31,  -6,-130, -28,-124, -35,   1,-119,-128, -53, -82,  19,  68,  47,-139, -29;
/M: SY='N';  M= -12,  -2, -48,   3, -63, -23, -40, -17, -54,-131,-124,  84, -36, -32, -12,  40,  48, -51,-144, -63;
/M: SY='C';  M=-123,  48,-138,-134,  39,-141, -51,  38,-132,  47,  30,-131, -34, -39,-134,-125,  38,  23,-130, -10;
/M: SY='P';  M= -31,-137,-119, -41,-130, -76,  21,-128,  -8, -33,  22,  23,  81,  35,  19,  34,   2,-128,-136,   9;
/M: SY='L';  M= -78,-131,-144,-136,  23,-144,-131,  42,-135,  72,  37,-139, -43, -55, -67,-133,-120,  28,-130,-111;
/M: SY='F';  M=-132, -51,-145,-140, 119,-141,-125, -45,-136, -63, -32,-135,-144, -58,-134, -42, -72, -24,  29,  38;
/M: SY='D';  M= -78,-134,  97, -22,-141, -17,-114,-139, -72, -88,-135,  58, -40, -31,-121,  33,  11,-135,-153,-130;
/M: SY='Y';  M= -26, -15, -20,  11,  39, -74,  59, -37,  28, -90, -47,-116,-131,   9, -13,  36, -72, -40,  21,  67;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='N';  M= -57, -12,  54,  16, -51, -51,  21, -85,  47,-136, -45,  59,-128, -19,  47, -37, -15,-134, -20, -66;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='G';  M= -20,  -8,  21, -48, -28,  67, -23,-136, -12, -30, -36,  59, -67, -69,   3,   7,-118,-134, -49, -63;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='T';  M= -36, -24, -28,   7, -17,-131,  26, -30,  27,  -5, -27, -20,-129,  39,  22, -15,  42,  20,  25, -25;
/M: SY='L';  M= -78,-130,-143, -79,  32,-144, -41,  -6,-136,  84,  53,-139,-141,-130,-134,-134, -65, -36,-127, -52;
/M: SY='R';  M= -59, -42,-122,-115,-126, -84, -46,  16,  47,   0, -21,  22, -59,   7,  78, -17, -27, -14,-136, -60;
/M: SY='Q';  M= -60,  14, -42, -51, -68, -46, -10,-129,  28, -54,  18, -11,-127,  90,  14,  33,  37, -78,-137, -53;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='G';  M= -69,-136,-123,-133, -64, 104, -50,-147,-126,-143, -38,  -8,-128,-125, -30, -70, -31,-141,-134,-135;
/M: SY='P';  M= -58,-134, -47,  14,   4,-129,  -9, -19,   2, -11,  10,  15,  39,  18,  31,  23,  21,  -4, -28, -34;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='Q';  M= -89, -47, -63,  -7,  31,-135,  47,  19, -11,  -8,  29, -10,-133,  70,  18, -53, -68,  -1, -14,  33;
/M: SY='K';  M= -10,   2,  -8,  -9,  -6,-130,   4, -23,  31,  20,-114, -15, -27,  20,  28,  12,  21, -44,-133,   7;
/M: SY='L';  M= -67,  36,-141,-134, -11,-142, -39,   6,-133,  77,  -6, -62,-141, -32, -44, -40,-120,  23, -27, -13;
/M: SY='H';  M=  -4, -19, -71, -38, -12,  -5,  52, -62,  36, -32,  -4,  19,  32,  -1,  15,  12, -15, -58, -28,  31;
/M: SY='M';  M= -39, -18,-141,-135,  17,-141,-129,  20,-134,  66,  72, -54,-138,-130,-133, -78, -14,  30,-131, -48;
/M: SY='W';  M=-128,-146, -19, -10, -39, -85,  29, -76,  -5, -42, -49, -63,-134,  -1, -42, -56,   8, -39, 156,  32;
/I:         I=-23; MI=0; MD=-58; IM=0; DM=-58;
/M: SY='P';  M= -82,-142,  19,  -6,-137,-127,-122,-131,  -4, -27, -19, -38, 103,  -5,  21,  13, -16,-132,-139, -40;
/I:         I=-38; MD=-97;
/M: SY='N';  M= -30,  18,  34,  25,  20,  23,  20, -59,-117, -55, -13,  53,  17, -20, -41,   4, -11, -75,  -7, -39; D=-38;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='T';  M= -16,-132,  20,  -1, -44, -19,-122,   0,  28, -33,  -3, -54,   1,-115,   7,  32,  43,  -1,-136,   8;
/M: SY='P';  M= -11,-139,  19,  38,  -3, -68, -24, -16,  29, -48, -64, -43,  63,  50,   2, -59, -20, -66,-134, -25;
/M: SY='A';  M=  42, -52,  27,  -2, -26, -81, -53,  14, -46, -18,-119,  17,  35,  -9, -69,  38, -23, -20,-139,-125;
/I:         I=-17; MD=-42;
/M: SY='D';  M= -94,-151,  66, -28,-150, -27, -19,-149, -15, -60,  15, -17, -39,  -4, -48,  33, -46,-147,-159, -30; D=-17;
/I:         I=-17; MI=0; MD=-42; IM=0; DM=-42;
/M: SY='C';  M= -29,  27, -52,-143, -67,  23,-145, -18, -24, -27,-140, -27,  -6,   3, -22,  -5, -77, -57,-154,  -7; D=-17;
/I:         I=-17; DM=-42;
/M: SY='S';  M= -37,  14, -38,  17, -78,  -5,  25,  -9, -45, -46,   7,  -1,-145, -35, -80,  41,-130,-139,-159,-141; D=-17;
/I:         I=-17; DM=-42;
/M: SY='C';  M= -45,  37,  12,  26,  -7, -40,-134, -31,   3, -70, -43,   3,  18, -19, -37, -25,   9, -18, -37,-136; D=-17;
/I:         I=-17; DM=-42;
/M: SY='M';  M= -35,-143,   2, -37, -28, -78, -26,   0, -80,   3,  46,   6,  37, -63, -10, -12, -40,  -2, -19,  32; D=-17;
/I:         I=-17; DM=-42;
/M: SY='T';  M=-126,-139, -72, -40,  18, -17, -20, -18,-125,  12, -44,   0, -80,  40,   2,   7,  43, -16,-140, -15; D=-17;
/I:         I=-17; DM=-42;
/M: SY='N';  M= -16,  23,  -5,  20, -49,   8,  26,-132,  19, -33,-124,  66, -40,  10, -65,   6,  26,-129, -19,  -4;
/M: SY='P';  M= -35,-136,  14, -36, -17,-126, -16, -45, -68, -70,  -5,  26,  91,  -6,-126,  -6,  51,-125,-135,  23;
/M: SY='P';  M=  -8, -11, -44, -33, -44, -27, -44,  38,   7,  11, -49, -62,  45, -29, -55,  18,  22, -17,  44,  -4;
/M: SY='G';  M=  -2,-133,-124, -20, -43,  63,  -1, -16, -56,  -2,  12,-116,  17,  -5, -44,  30,   2, -29,-135, -65;
/M: SY='T';  M= -15, -14, -61, -23, -45, -80, -15, -12,  21, -15, -21, -14,  26,   3,  24, -15,  67,   1,-139, -52;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='T';  M=  -9,  43,  19, -10,-127, -23,-125,   0,   8, -19, -20,  -4,  -7,  -7, -16,   9,  43,  24,-142, -59;
/M: SY='Y';  M=  -9,  17, -50, -17, -18,   5,  30, -24, -50,   5, -29, -12,  22,  19,  -9,   3, -22,  28,-131,  36;
/M: SY='S';  M= -43, -11,  18,  35, -68, -28,  20, -35, -35,  -6,  -8,  25,  27,  -1, -34,  39,  21, -81,   6, -10;
/M: SY='N';  M=-122, -49,  13,  -9,  -1, -82,  36,  -9,  10, -24,-120,  83,  -5, -25,  14, -14,  10, -47,-139,  -6;
/M: SY='P';  M= -39,-137,  23,  -9,   6,   4,-122,   5,  -8,  -1, -21,  11,  67,  -9, -17,   6, -37, -41, -26, -12;
/M: SY='E';  M=  -4, -41,  48,  52, -74, -58,  36, -62, -35, -15, -43,  31, -66,   4,  -3,  19,  -5, -64, -22,  -9;
/M: SY='R';  M= -17, -38,-124, -14, -13, -11,  25, -43,  17,   1,  23, -31,   5,  28,  31,  11, -28,  13,  15,   8;
/M: SY='D';  M= -25, -51,  51,  20,-136,  14,-117,-133,   5, -72, -15,  35,  47,  21, -26,  18, -10, -55,-141, -23;
/M: SY='R';  M=  -9, -56,  14,  41,   6, -87,   5, -13, -33, -56, -20,  24, -15,   0,  42,  23,  16, -28,-138, -56;
/M: SY='C';  M=  12,  35, -44, -26, -45, -47,  28,  -6, -75,  16,  25, -58,  33,  35, -52,  31, -29,   6,-136,  -9;
/M: SY='P';  M=   3, -29,  -2,  32,  -6, -34,-124,  14, -22, -11,  26, -17,  45,  -8, -17, -13, -14,  18,-136, -35;
/M: SY='W';  M= -11, -64, -11,   7,  -3,-134, -51,  25,  27,  21, -51,-123,  -5, -35,  38, -18,  -7, -13,  71,-116;
/M: SY='L';  M= -84, -19, -27,  -2,  11,-138,  16,  27, -41,  59,  36,-128, -15,  24, -28, -25, -47, -28,-131, -22;
/M: SY='D';  M= -32,-134,  47,  16,  19, -54,  12,  25, -54,   7,  43, -45, -11,  28,-123,   0, -11,  -9,-134, -20;
/I:         I=-26; MD=-67;
/M: SY='K';  M= -23, -13,   2,  11, -55, -37,   1, -68,  47, -24,-130,  42, -14, -15,  -5, -19, -25, -89,  29, -36; D=-26;
/I:         I=-26; MD=-67;
/M: SY='F';  M= -90,-146,  -8,   0,  41, -65, -18, -19,  -9,  24, -25,-134,  -5,  -1, -86,  15, -46, -76, -30, -32; D=-26;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='I';  M= -39,-133,-136, -33,  15, -28,-131,  67,   6,  18,   7,-131,-135,-127, -43, -71, -71,  43,-128,  24;
/M: SY='E';  M=-118,  -7,  20,  59, -63, -88,   2, -30,  12, -14,-121, -16,-125,  17,   4,  27,  34, -27,-138,  -3;
/M: SY='F';  M=-128,-134,-132, -18,  90, -66,-121,  -1,  16,  25,  -9,  -3, -69,-124,  24, -56,-123,-113, -31,  26;
/M: SY='P';  M=-123,-142,  22,  30,-141, -34,  34,-135,  36,-100,-127,   2,  91,  30, -14,-117, -39, -48,-141,-130;
/I:         E1=0; IE=-380; DE=-380;

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Post-processing [info]

COMPETES_HIT_WITH

PS50004

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.

Total number of hits	40 in 40 different sequences
Number of true positive hits	40 in 40 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	C2 PI3K-type
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

40 sequences

AGE1_CAEBR  (P0C5E7), AGE1_CAEEL  (Q94125), P3C2A_HUMAN (O00443),

P3C2A_MOUSE (Q61194), P3C2A_PONAB (Q5RAY1), P3C2B_HUMAN (O00750), 
P3C2G_HUMAN (O75747), P3C2G_MOUSE (O70167), P3C2G_RAT   (O70173), 
PI3K1_DICDI (P54673), PI3K1_SOYBN (P42347), PI3K2_DICDI (P54674), 
PI3K2_SOYBN (P42348), PI3K3_DICDI (P54675), PI3K4_DICDI (P54676), 
PI3K_ARATH  (P42339), PIKI1_CAEEL (G5EDY0), PK3C3_CAEEL (Q9TXI7), 
PK3C3_HUMAN (Q8NEB9), PK3C3_MOUSE (Q6PF93), PK3C3_PIG   (Q5D891), 
PK3C3_RAT   (O88763), PK3C3_XENLA (Q6AZN6), PK3CA_BOVIN (P32871), 
PK3CA_HUMAN (P42336), PK3CA_MOUSE (P42337), PK3CA_RAT   (A0A0G2K344), 
PK3CB_HUMAN (P42338), PK3CB_MOUSE (Q8BTI9), PK3CB_RAT   (Q9Z1L0), 
PK3CD_HUMAN (O00329), PK3CD_MOUSE (O35904), PK3CG_HUMAN (P48736), 
PK3CG_MOUSE (Q9JHG7), PK3CG_PIG   (O02697), VPS34_CANAL (A0A1D8PDV7), 
VPS34_CANAX (Q92213), VPS34_CANGA (Q6FSR7), VPS34_SCHPO (P50520), 
VPS34_YEAST (P22543)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

295 PDB

1E7U; 1E7V; 1E8W; 1E8X; 1E8Y; 1E8Z; 1E90; 1HE8; 2A4Z; 2A5U; 2CHW; 2CHX;
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