PROSITE entry PS51054

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51054
Entry name [info]	ORANGE
Accession [info]	PS51054
Entry type [info]	MATRIX
Date [info]	01-JAN-2005 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51054
Associated ProRule [info]	PRU00380

Name and characterization of the entry

Description [info]

Orange domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=39;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=34;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.9421368; R2=0.0002471; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=155219.2187500; R2=0.6785432; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=20065; H_SCORE=168834; N_SCORE=7.9; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=14399; H_SCORE=164990; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: B1=*; E1=*; MM=*; II=*;

...

                A     C     D     E     F     G     H     I     K     L     M     N     P     Q     R     S     T     V     W     Y
/I:         B1=-8455; E0=*; BM=-49; BD=-4907;
/M: SY='Y';  M=-1156,-5417,-6960,-7224, 3321,-6792,-3119,-5246,-6774,-1417,-4680,-5488,-6667, -944,-6193,-6029,-6211,-5402,-2374, 3938; M0=-4334;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='H';  M=  -59,  916,-2252,-1701,-3583, -960, 2256,-3253, 1641, -547,  581,-1983, -343, -382, 1703,  427,-2189, -880,-3647,  173; M0=-730;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='S';  M= 1410,-3688,  942,  770,-4008, -834,  657, -899,-1431,-3704,-2777, -200,-3285,  889, -758, 1412, -586, -966,-3872,  218; M0=-822;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='G';  M=-6356,-6146,-7148,-7458,-7928, 3833,-6916,-8631,-7266,-8260,-7899,-7087,-6750,-7339,-1272,-6645,-6728,-7827,-6892,-7871; M0=-6265;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='Y';  M=-6622,-5564,-7036,-7370, 3223,-6909,-3113,-5485,-6874,-4792,  813,-5530,-6764,-5656, -615,-6158,-6474,-5657,-2361, 4048; M0=-4926;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='R';  M= -865,-3415,-2231,-1680,-3624,-3273, 1543,  120, -267,-3383,  391, -147,-3363,  138, 2295, 1347,  335,   -4,-3670,  171; M0=-974;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='E';  M= -785,-3691,  259, 2127,-4012, -728, 1512,-3763, -271,-3707,  587, -200,-3284,  970,  882,  151,  432,-3313, 1164,-3191; M0=-1072;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='C';  M=  988, 5460,-6454,-6805,-6429,  249,-5764,-6266,-6447,-6525,-5557,-4842,-4808,-5879,-6038,-3369,-3592,-4937,-6609,-6636; M0=-4534;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='L';  M= 1164,-3898,-6656,-6062, -197,-6068,-4943,  432,-5745, 2398, 1726,-5732,-5784,-5086,-5468,-5234,-4173, 1028,-4291,-4188; M0=-3071;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='N';  M=  381,-3691,  410,  678,-4012,-3191, 1487,-3763,  562, -451,-2780, 1500, -341, 1334,  421,   14, -545,-3313,-3874,  233; M0=-769;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='E';  M=-2670,-4096,-2405, 3020,-4461, -729,-2175,-4178, -191,-4088,-3193,   -1,-3667,  940, 1680,-2542, -400,-3746,-4213,-3590; M0=-1871;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='V';  M= 1158,-2743,-5362,-4775,-2838,-4596,-3598,  528,-4408,  260,-2003,-4277,-4645,-4058,-4239,   40, 1180, 2600,-3449,-3096; M0=-2017;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='A';  M= 1698,-2577,-3390, -784,-2576,-3716,  620, -488,-2637, -287,-1765,  379,-3785,-2479,-2875, 1684,  397, 1115,-2995,-2593; M0=-1064;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='R';  M= -106,-3693,  322,-1518,-4014, -795, 2248,-3765, -216,-3709,-2782,   59,-3287, 1774, 2442,  542, -443,-3315,-3876,-3194; M0=-1273;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='F';  M=-3380,-3147,-5525,-5016, 3672,-4831,-3024, -273,-4597,-2909,-2357,-4317,-4859,-4122, -358,-1067,-3318,  704,-2581, 2669; M0=-2572;
/I:         MM=-47; MI=-10019; MD=-5016; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='L';  M=-1142,-4330,-7187,-6598,  152,-6727,-5542, 1056,-6326, 2788, 1620,-6409,-6196,-5443,-5964,-5954,-4676,  191,-4555,-4598; M0=-3566;
/I:         MM=-2; MI=-9974; MD=-11016; IM=-894; II=-1115; DM=-1379; DD=-700;
/M: SY='S';  M=  752,-3579, -307,-1519,-3867,-3175, 1572,-3594,-1431, -386,  512,  -24, -558,-1389,  662, 2066,  951,-3183,-3783,-3121; M0=-972;
/I:         MM=-2; MI=-9974; MD=-11016; IM=-894; II=-1115; DM=-1379; DD=-700;
/M: SY='C';  M=  486, 1795, -391,  372, -418,   12,-1815,-3715, -150, -573,-2737,-1792, -304, 1689, -240,   77, 1580,-3268,-3832,-3151; M0=-633;
/I:         MM=-2; MI=-9974; MD=-11016; IM=-894; II=-1115; DM=-1379; DD=-700;
/M: SY='C';  M=   10, 2791,-2551,  314,-3074, -710, 2740, -634, -189,-1208,  436,-2218, -670,  160,-2300, -586,  342, 1111,-3324,-2818; M0=-658;
/I:         MM=-2; MI=-9974; MD=-11016; IM=-894; II=-1115; DM=-397; DD=-2056;
/M: SY='E';  M= -803,-3712,  938, 2034,-4033, -834,-1867,-3784, -288,-3728,-2801,-1839, 1569, 1351,  435,  876,-2177,-3334,-3895,-3211; M0=-1217;
/I:         MM=-206; MI=-10019; MD=-2921; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='G';  M=  565,-3522,  -22,-1350,-3842, 1922, 1863,-3593, -115,-3538,-2611,   91, -527,  373,   38, -429, -175,  620,-3706,-3023; M0=-840;
/I:         MM=-2; MI=-9815; MD=-10857; IM=-894; II=-1115; DM=-1525; DD=-616;
/M: SY='M';  M=-2169,-2916,  653,  900,-3013, -688,-2000, 1212,-1768,  437, 2118,-2108, -581, 1358,-2192, -667,  502, -136,-3253,-2742; M0=-621;
/I:         MM=-291; MI=-9867; MD=-2461; IM=-894; II=-1115; DM=-2266; DD=-336;
/M: SY='D';  M=-1872, 1282, 1943, 1774,  216,-2843, 1125,-3410,-1087,-3356,-2431,  155,  538,-1046,  916,  455,-1812,-2962,-3526,-2844; M0=-1057;
/I:         MM=-335; MI=-9579; MD=-2278; IM=-894; II=-1115; DM=-93; DD=-4004;
/M: SY='P';  M=  113,-2708,  528,  414,-2772,  289,-2015, -236,-1854, -756,  620,-2171, 1990,-1764,-2244, -643, 1360,  238,-3070,-2592; M0=-563;
/I:         MM=-4946; MI=-3034; MD=-242; IM=-60; II=-4609; DM=-2696; DD=-242;
/M: SY='D';  M=-1730,-2975, 3326, -275,-3643,-1803,-1310,-3623,-1522,-3575,-2922, -626, 2100,-1017,-2231,-1531,-1863,-3088,-3548,-2870; M0=-1661;
/I:         MM=-16; MI=-7093; MD=-8135; IM=-894; II=-1115; DM=-144; DD=-3401;
/M: SY='Q';  M=  429,-3607,  957,  423,-3929,  511,  659,-3679, 1021,-1239,-2697,-1743, -560, 1846,-1855,  607,  487,-3229,-3791,-3108; M0=-805;
/I:         MM=-2; MI=-9918; MD=-10960; IM=-894; II=-1115; DM=-260; DD=-2598;
/M: SY='V';  M= -111,-2488,-3667,  275,   70,-3791,-2591, -305, 1180,  220, 1484,-3031,-3855,  653,-3036,  462,  232, 1536,-2918,-2535; M0=-863;
/I:         MM=-2; MI=-10019; MD=-11061; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='R';  M=-2223,  844,-2075, -374,-3998, 1207, 1445,-3744,  398,-1165,-2772,-1836,-3291,  792, 2364,  526, -393,-3301,-3868,  219; M0=-1033;
/I:         MM=-1546; MI=-10019; MD=-607; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='E';  M=  329,-2495,  801, 1604,-2790,-2069, -733,-2522, -325, -285, 1528, 1118,-2163, -282, -828,  410,  648,-2103,-2695,-2029; M0=-579;
/I:         MM=-6; MI=-8479; MD=-9521; IM=-894; II=-1115; DM=-4501; DD=-65;
/M: SY='K';  M=-2698,-3598,-3016,-2036,-4163,-3391,-1489,-3720, 3249,-3474,-2746,-2067,-3380,-1070, 1266,  452,-2477,-3438,-3377, 1569; M0=-1962;
/I:         MM=-1285; MI=-8479; MD=-769; IM=-894; II=-1115; DM=-4501; DD=-65;
/M: SY='M';  M= 1532, -816,-2776,-2232, 2159,-2313,-1247,   -4,-1925,  -21, 2997,-1896,-2408,-1600,-1878,-1432, -866,  -67,-1134, -677; M0=-890;
/I:         MM=-15; MI=-7208; MD=-8250; IM=-894; II=-1115; DM=-3037; DD=-187;
/M: SY='C';  M=-1023, 4272,-3877,-3738,-2582,-2063,-2815,-1365,-3392,-2328,-1737,-2574,-2717,-3028,-3215, 1321,-1356, 2269,-3111,-2812; M0=-1796;
/I:         MM=-308; MI=-7847; MD=-2411; IM=-894; II=-1115; DM=-447; DD=-1908;
/M: SY='Q';  M= 1412,-2962,-1996,-1445,   29,-2989,-1672, -212,  -54,-2910,-2094,-1715,  -15, 1637,  742, 1173,  691, -531,-3246,-2672; M0=-729;
/I:         MM=-3; MI=-9618; MD=-10660; IM=-894; II=-1115; DM=-3232; DD=-162;
/M: SY='R';  M=-1918,-3317,-1796,   11,-3611, -568, 1173,-3339,  153, -846, 1836,-1549,-2993, 1624, 2680,-1813, -216, -625,-3514,-2853; M0=-1007;
/I:         MM=-3; MI=-9618; MD=-10660; IM=-894; II=-1115; DM=-99; DD=-3909;
/M: SY='L';  M=-2609,-2431,-4935, -669, -155,-4164,-3033,  567,-3905, 2747,  730, -284, -660,-3518,-3708,-3250,-2549, -470,-2879,-2550; M0=-1735;
/I:         MM=-59; MI=-10019; MD=-4668; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='M';  M=-2449, 2602,-4796,-4161, -103,-4002,-2875,  414,-3758, 1842, 2836, -138,-4049,-3380,-3558, -996,-2390, 1139,-2736,-2395; M0=-1732;
/I:         MM=-2; MI=-9912; MD=-10954; IM=-894; II=-1115; DM=-355; DD=-2199;
/M: SY='Q';  M=  507,-3652, -388, -308,-3973,-1019,  707, -529,  994,-3668,-2741,  654, -373, 1800, -370,  464, 1204,-3274,-3835,  -21; M0=-753;
/I:         MM=-2; MI=-9971; MD=-11013; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='H';  M= -869,-3119,-3147,-2557,  903,-3793, 4536,-2771,-2162,-1148,-2291,  657,-3859,  184,  633,-2783,-2557,-2610, 1531,-2592; M0=-1719;
/I:         MM=-2; MI=-9971; MD=-11013; IM=-894; II=-1115; DM=-701; DD=-1378;
/M: SY='L';  M=-3210,-3024,-5418,-4702, 1678,-4743,-3504,-2132, -462, 2776,  847,-4294,-4706,-3788, -288,-3854, -426,-2295,-3369,-3094; M0=-2271;
/I:         B0=*; E1=-1000;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.

Total number of hits	66 in 66 different sequences
Number of true positive hits	66 in 66 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	2
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	97.06 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	PS_Langendijk_Genevaux
Feature key [info]	DOMAIN
Feature description [info]	Orange
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

66 sequences

BHE40_BOVIN (Q5EA15), BHE40_HUMAN (O14503), BHE40_MOUSE (O35185),

BHE40_PONAB (Q5RAI7), BHE40_RAT   (O35780), BHE40_SHEEP (B3F209), 
BHE41_HUMAN (Q9C0J9), BHE41_MOUSE (Q99PV5), BHE41_RAT   (O35779), 
CWO_DROME   (Q9VGZ5), DPN_DROME   (Q26263), ESM3_DROME  (Q01068), 
ESM5_DROME  (P13096), ESM7_DROME  (P13097), ESM8_DROHY  (Q07291), 
ESM8_DROME  (P13098), ESMB_DROME  (Q01069), ESMC_DROME  (Q01070), 
ESMD_DROME  (Q01071), HAIR_DROME  (P14003), HAIR_DROVI  (P29303), 
HE71A_XENLA (Q8UW74), HE71B_XENLA (Q8UW72), HELT_DANRE  (Q6QB00), 
HELT_HUMAN  (A6NFD8), HELT_MOUSE  (Q7TS99), HES1A_XENLA (Q6IRB2), 
HES1B_XENLA (Q8AVU4), HES1_BOVIN  (Q3ZBG4), HES1_CHICK  (O57337), 
HES1_HUMAN  (Q14469), HES1_MOUSE  (P35428), HES1_RAT(Q04666), 
HES1_XENTR  (Q5PPM5), HES2_HUMAN  (Q9Y543), HES2_MOUSE  (O54792), 
HES2_RAT(P35429), HES3_MOUSE  (Q61657), HES3_RAT(Q04667), 
HES4A_XENLA (Q90Z12), HES4B_XENLA (Q90VV1), HES4_HUMAN  (Q9HCC6), 
HES4_XENTR  (Q6PBD4), HES5_HUMAN  (Q5TA89), HES5_MOUSE  (P70120), 
HES5_RAT(Q03062), HES6_HUMAN  (Q96HZ4), HES6_MOUSE  (Q9JHE6), 
HES71_XENTR (Q28HA8), HES7_HUMAN  (Q9BYE0), HES7_MOUSE  (Q8BKT2), 
HEY1_BOVIN  (Q2KIN4), HEY1_CANLF  (Q9TSZ2), HEY1_DANRE  (Q8AXV6), 
HEY1_HUMAN  (Q9Y5J3), HEY1_MOUSE  (Q9WV93), HEY1_XENLA  (Q9I8A3), 
HEY1_XENTR  (Q66KK8), HEY2_DANRE  (Q9I9L0), HEY2_HUMAN  (Q9UBP5), 
HEY2_MOUSE  (Q9QUS4), HEYL_BOVIN  (Q2NL18), HEYL_DANRE  (Q8AXV5), 
HEYL_HUMAN  (Q9NQ87), HEYL_MOUSE  (Q9DBX7), HEY_DROME   (Q7KM13)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

2 sequences

HES2_XENLA  (Q00P32), HES3_HUMAN  (Q5TGS1)

PDB
[Detailed view]

2 PDB

2DB7; 7C4O