PROSITE entry PS51039

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51039
Entry name [info]	ZF_AN1
Accession [info]	PS51039
Entry type [info]	MATRIX
Date [info]	01-NOV-2004 CREATED; 02-JUN-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51039
Associated ProRule [info]	PRU00449

Name and characterization of the entry

Description [info]

Zinc finger AN1-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=50;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=45;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3496473; R2=0.0103997; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1313; N_SCORE=16.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=400; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-32; D=-120; I=-120; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='P';  M=  24, -74,  -6, -26, -72, -67, -64, -37,  48, -13, -58, -59,  59,  25, -10, -41,   8,  13, -78, -68;
/M: SY='K';  M= -21, -75,  47, -23, -74, -40,  34,  -6,  60, -53, -62, -26,  12,  14, -29, -23,  12,   3, -82, -64;
/M: SY='K';  M=  12, -71, -37, -48,  22, -28, -65,   4,  46,  14, -53, -12,  -5, -57,   0,  12,  19, -16, -72, -58;
/M: SY='K';  M= -24, -74,  12, -53, -77,  42, -62, -73,  55, -75, -22, -28,  20,  -6,   7,  11,  22, -26, -78, -69;
/M: SY='N';  M= -14, -72, -50, -31, -18, -36,  26, -70,  40, -72, -63,  80,   1,  -5,  13,   3, -37, -20, -75,  21;
/M: SY='H';  M= -31, -78, -59, -51, -74, -42,  87, -79,  35, -73, -61, -50, -22, -12,  80, -29,  17, -74, -81, -56;
/M: SY='C';  M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82;
/M: SY='S';  M=  21,   5, -26, -16,  27, -25, -28, -66, -20, -21, -62,  -6,  34,   6, -63,  61, -19, -48, -72,  -7;
/I:         I=-31; MD=-65;
/M: SY='F';  M= -76, -24, -41,   0,  47, -94,   0, -19, -16, -17,   4, -82, -90, -77,  -3, -80, -73,  39, -80, -16; D=-31;
/I:         I=-31; MD=-65;
/M: SY='P';  M= -25,-102,  -1,   6,-105, -57, -85, -99,  23,-102, -93, -78,  54, -33, -76, -14, -19, -96,-103, -96; D=-31;
/I:         I=-31; MI=-65; MD=-65; IM=-65; DM=-65;
/M: SY='T';  M=   5, -79,  28, -61, -82,  18,   2, -80,   4, -81, -74, -56, -74, -17,  23,  14,  42, -53, -88, -28; D=-31;
/I:         I=-31; DM=-65;
/M: SY='C';  M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82;
/M: SY='R';  M= -34, -76, -56, -50, -77,  -1, -55, -78,  51, -76, -65,  30, -13,  21,  73,   3,  13, -73, -77, -66;
/M: SY='K';  M= -18, -77, -23,  29, -76, -70, -57, -47,  64, -32, -61, -53, -65,  59,  39, -21,  -3, -15, -76, -65;
/M: SY='K';  M= -29, -74, -65, -56, -62, -43, -61,  11,  57,  23,   5, -58, -71, -51,  52,  12,  -5, -31, -73, -15;
/M: SY='D';  M= -28, -71,  58,  40, -63, -75, -66, -43, -61,  14, -53, -58, -69, -59, -66, -58,  24,  57, -86, -65;
/M: SY='F';  M= -57, -71, -68, -22,  65,  58, -66, -60, -67,  -9,  39, -58, -71, -67, -71,  -2,  43, -60, -64, -49;
/M: SY='L';  M= -65, -69, -80, -74,  32, -83, -69,   3, -28,  70,  24, -76, -79, -69, -23, -70,   8,  12, -69, -50;
/M: SY='P';  M=   4, -72, -66, -22, -17, -68, -65, -54,   0,  21,  37, -62,  65,   5, -63,  11,  41, -21, -76, -63;
/I:         I=-29; MD=-61;
/M: SY='G';  M= -36, -96, -80, -90,-101,  62, -85, -38, -85,-101, -91,  31, -91,  -9, -91, -47, -47, -96,-100, -96; D=-29;
/I:         I=-29; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='F';  M= -66, -72, -80, -75,  92,   3, -68,  21, -72,   8,  -1, -71, -79,  20, -72, -31, -63,   9, -54, -15;
/M: SY='K';  M= -22, -73,   6,  20,  12, -35,  15,  -3,  43, -64, -33,  18, -10, -34,  11,  -9,  31,  -2, -77, -60;
/M: SY='C';  M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82;
/I:         I=-36; MD=-77;
/M: SY='D';  M= -26, -97,  58, -42, -97, -85, -76, -91,  -1, -47,  20, -16,  16,  -3, -12, -39, -77, -90,-105, -87; D=-36;
/I:         I=-36; MI=-77; IM=-77; DM=-77;
/M: SY='R';  M=  -7, -78,  15, -53,   0,   7,  43, -74,   1, -29, -61, -10, -73,   8,  80, -58, -63, -71, -71,  21;
/M: SY='C';  M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82;
/M: SY='G';  M= -52, -73, -32, -11, -78,  70,  19, -80,  28, -43, -69,  28, -67, -17, -58,  34, -25, -76, -78, -69;
/M: SY='G';  M=  -9, -74, -57,  -6, -39,  45,  41, -36,  11, -30, -61,  33, -69,  30,  14,   6, -34, -20, -75,  -2;
/M: SY='N';  M= -60, -71,  24, -27, -64, -69,   4,   0,  -9,  -3,  28,  59, -71, -18,  21, -26,  25,  30, -85, -62;
/M: SY='F';  M= -74, -73, -81, -79, 110, -81,  33, -51, -75, -44, -50, -73, -84, -79, -71, -71, -67, -29, -40,  63;
/M: SY='C';  M= -62, 152, -81, -81, -30, -77, -79, -77, -77, -68, -68, -67, -92, -84, -83, -64, -61, -66, -94, -14;
/M: SY='L';  M=  21, -70, -73, -70, -57,  43, -68,  19, -20,  48,  28, -64, -41, -64, -70,   8, -59, -48, -74, -62;
/M: SY='K';  M=  15, -72,  23,  30, -74, -45, -58, -68,  48, -21, -11, -18, -65,  17,   3,  30,   5, -31, -79, -66;
/M: SY='H';  M= -69, -81, -53, -53, -68, -71, 149, -86, -58, -68, -54, -43, -70, -47, -52, -59, -68, -86,-103, -37;
/M: SY='R';  M= -30, -81, -64, -53, -12, -75,  38, -76,   0, -71, -62, -57,  -8, -43, 105, -61, -64, -29, -76, -58;
/M: SY='Y';  M= -28,   9, -69, -35,  48, -37,  67, -55, -67,  29, -48, -63, -50, -62, -66,  15, -19, -58, -54,  76;
/M: SY='P';  M=  11, -78, -64,  -6, -60,  -6, -58, -66, -17, -31,  26, -63,  82,   4, -37,  15, -43, -66, -64,  58;
/M: SY='E';  M=  -3, -76,  39,  69, -17, -24, -59, -69, -13,  -9,  -1, -55,  14, -47,  -2,  -6,   5, -50, -79, -66;
/M: SY='D';  M= -18, -76,  75,   3, -77, -39, -20,   3,  14, -71, -66,  23, -67,  37,  -6,   7, -11, -21, -86, -66;
/M: SY='H';  M= -27, -80, -54, -54, -65, -70, 146, -84, -58, -68, -54, -44, -70, -48, -53, -58, -67, -83, -96,   3;
/M: SY='D';  M=   0, -74,  49,  16, -79,  32,  26, -78,  36, -77, -69,  18, -66, -23, -10,  21, -24, -40, -83, -67;
/M: SY='C';  M= -27, 151, -81, -80, -70, -76, -80, -75, -76, -31, -66, -68, -91, -83, -82, -63, -61, -64, -99, -80;
/M: SY='P';  M=  -1, -74, -59, -10, -76,  23, -63, -71,  -5, -75, -67,   5,  61,  11,  -7,  38,  29, -31,  36, -68;
/M: SY='F';  M= -16, -75, -62,  16,  62,  37,  -3, -66,  18, -29, -60,  -5, -14, -59, -28,  -7, -29, -66,  17,  35;
/M: SY='D';  M=  14, -76,  65, -12, -73,  -3, -60, -32,  18,   5, -62,  -8,  23, -54,  27, -34, -58, -29, -82, -67;
/M: SY='Y';  M=   3, -74, -19,  16,  44, -10,  10, -14, -30, -15, -55,  -1, -15, -59,  -8, -12,  -8, -26, -56,  71;
/M: SY='K';  M= -12, -76, -25, -24, -72, -69,  32,   2,  62, -65,   8, -10, -68,  44,  40,   7, -56,  -3, -77, -61;
/M: SY='P';  M=  19,   5, -62, -14, -73,  27,  -8,   2,  22, -23, -61, -20,  43,  12, -11,  19,  -9, -41, -77, -68;
/M: SY='A';  M=  38, -72,  34,  18, -75, -36,  37, -36,  12, -69, -22,   1,   6, -51,  21,  -9,  13, -11, -83, -65;
/M: SY='A';  M=  43, -70, -41,   8, -27,  38, -66,  -7, -23, -35, -61, -18,  -1, -57,   7,  27, -55,   1, -76, -67;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.

Total number of hits	80 in 64 different sequences
Number of true positive hits	80 in 64 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	ZN_FING
Feature description [info]	AN1-type
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

64 sequences

CUZ1_YEAST  (P53899), SAP10_ARATH (Q9STJ9), SAP10_ORYSJ (Q69LE0),

SAP11_ARATH (Q8VZ42), SAP11_ORYSJ (Q84PD8), SAP12_ARATH (Q67YE6), 
SAP12_ORYSJ (Q6Z541), SAP13_ARATH (Q9SCM4), SAP13_ORYSJ (Q5JLA7), 
SAP14_ORYSJ (Q852K8), SAP15_ORYSJ (Q0DJC7), SAP16_ORYSJ (Q0D5B9), 
SAP17_ORYSJ (Q6H595), SAP1_ARATH  (Q6NNI8), SAP1_ORYSI  (A2Z2J6), 
SAP1_ORYSJ  (A3C039), SAP2_ARATH  (Q8H0X0), SAP2_ORYSJ  (Q942F8), 
SAP3_ARATH  (Q9ZNU9), SAP3_ORYSJ  (Q5JN07), SAP4_ARATH  (Q9SJM6), 
SAP4_ORYSJ  (Q6H7P8), SAP5_ARATH  (Q9LHJ8), SAP5_ORYSJ  (Q6H754), 
SAP6_ARATH  (Q94B40), SAP6_ORYSJ  (Q852K5), SAP7_ARATH  (Q9SZ69), 
SAP7_ORYSJ  (Q852K6), SAP8_ARATH  (Q3EA33), SAP8_ORYSI  (A2YEZ6), 
SAP8_ORYSJ  (A3BDI8), SAP9_ARATH  (O49663), SAP9_ORYSJ  (Q7Y1W9), 
SMBP2_HUMAN (P38935), SMBP2_MESAU (Q60560), SMBP2_MOUSE (P40694), 
SMBP2_RAT   (Q9EQN5), TMC1_YEAST  (Q08422), Y8260_DICDI (Q55GW8), 
YHM5_SCHPO  (O94338), ZFAN1_HUMAN (Q8TCF1), ZFAN1_MOUSE (Q8BFR6), 
ZFAN3_HUMAN (Q9H8U3), ZFAN3_MOUSE (Q497H0), ZFAN3_RAT   (Q5U2M7), 
ZFAN3_XENLA (Q66J85), ZFAN4_HUMAN (Q86XD8), ZFAN4_MOUSE (D3Z3C6), 
ZFAN5_HUMAN (O76080), ZFAN5_MOUSE (O88878), ZFAN5_RAT   (B5DF11), 
ZFAN6_BOVIN (Q3SZY7), ZFAN6_HUMAN (Q6FIF0), ZFAN6_MOUSE (Q9DCH6), 
ZFAN6_PONAB (Q5R7S6), ZFAN6_RAT   (Q6DGF4), ZFAND_DICDI (Q55BU1), 
ZFN2A_HUMAN (Q8N6M9), ZFN2A_MOUSE (Q9JII7), ZFN2A_PONAB (Q5R966), 
ZFN2A_RAT   (Q5U2P3), ZFN2B_HUMAN (Q8WV99), ZFN2B_MOUSE (Q91X58), 
ZFN2B_RAT   (Q4KLG9)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

13 PDB

1WFE; 1WFF; 1WFH; 1WFL; 1WFP; 1WG2; 1WYS; 1X4V; 1X4W; 5IJ4; 7QXW; 7Y7L;
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