PROSITE entry PS50888

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50888
Entry name [info]	BHLH
Accession [info]	PS50888
Entry type [info]	MATRIX
Date [info]	01-APR-2002 CREATED; 07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00038
Associated ProRule [info]	PRU00981

Name and characterization of the entry

Description [info]

Myc-type, basic helix-loop-helix (bHLH) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=53;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=48;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4081862; R2=0.0063509; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=6086.8779297; R2=2.0289094; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=960; H_SCORE=8035; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=645; H_SCORE=7396; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-24; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='Q';  M=   8, -31,  11,  11, -28, -34,  -9, -37,  -1, -19,  -6,   8,   7,  34,  24,  20,  -7, -22, -77,  -8;
/M: SY='R';  M=  11, -16, -38, -13, -34, -16, -36, -30,  34, -32,  -3, -16, -17,  26,  64,   2, -24, -46, -75, -25;
/M: SY='R';  M= -24, -38, -42, -27, -73, -46, -25, -63,  48, -42, -44, -44,  -1,  -4,  79,  -1,  14, -31, -76, -26;
/M: SY='R';  M=   3, -73,   8,  21, -51,  -2, -15, -21,  10,  -1,  25, -21, -32,   7,  29,  18, -14,  -5, -16, -63;
/M: SY='S';  M=  15, -48, -51, -17, -41, -46,   2, -35,  32, -16,   2,  26,  17, -11,   7,  34,  25, -26, -79, -41;
/M: SY='H';  M=  18, -74, -36, -47, -72, -32, 107, -46,  20, -51, -59,  16, -20,  -8,  13,  14, -19, -49, -86, -44;
/M: SY='N';  M= -18, -33, -34, -43, -43, -37, -56, -14,   1, -25, -23,  77,  16, -42,   9,  36,   5,  -6, -83, -56;
/M: SY='E';  M=  17, -17,   8,  36, -48, -27,  -2,   8, -23,  10,  12,   0, -27,  -5, -18,  14, -33,   1, -45, -43;
/M: SY='R';  M=  30, -71, -34, -25, -64, -39, -63,   8, -20,   7,  21, -20,  -3, -30,  52,   7,   4,   0, -77, -41;
/M: SY='E';  M=   2, -78, -20, 100, -55, -54, -55, -64, -26, -67, -70, -28, -19, -38, -24, -13, -46, -61, -80, -72;
/M: SY='R';  M= -55, -81, -46, -40, -66, -62, -54, -63,  61, -51, -17, -42, -32,  13,  94, -59, -62, -73, -74, -63;
/M: SY='R';  M= -26,   0, -19, -16, -72, -37, -14, -27,  40, -16, -35,  24, -70,  40,  61,  -5, -16, -20,  -2, -63;
/M: SY='R';  M= -66, -82, -34, -42, -72, -44,  -9, -79,  -9, -32, -62, -37, -39, -35, 109, -47, -65, -74, -74, -15;
/M: SY='R';  M= -61, -39, -56, -38, -68, -77, -55, -39,  -5, -11,  41, -44, -74, -17, 100, -62, -25, -12, -76, -61;
/M: SY='E';  M=   5, -31,  40,  45, -29, -35,  21, -47,  14, -60, -66,  15, -32,  33,  23,   2, -35, -60, -78,  -7;
/M: SY='K';  M= -19, -37,  24,   5, -77, -36,  16, -70,  54, -48, -27,  24, -67,  37,  52,  -9, -21, -63, -79, -64;
/M: SY='I';  M= -63, -73, -76,   8, -14, -84, -71,  68, -71,  41,  64, -63, -74, -45, -73, -71, -36,  12, -73, -38;
/M: SY='N';  M= -17, -69, -43, -46, -56, -29, -13, -76,  20, -79, -68, 102, -70, -18,  19,  17, -13, -74, -87, -68;
/M: SY='E';  M= -13, -56,  47,  53, -57, -25,   6, -49,   0, -18, -20,   8, -65,  11,   5,  10,   1, -32, -81, -28;
/M: SY='C';  M=  32,  60, -64,  -5, -47, -12,   4, -45,  19,  -8, -15, -59, -70, -20,  41,  14, -45, -32, -15,  11;
/M: SY='F';  M= -68,  -4, -84, -80,  80, -84, -67,  39, -76,  40,  34, -77, -82, -76, -75, -73, -46,  -9, -55,  28;
/M: SY='E';  M=   3, -48,  32,  37, -18, -48,   4, -36,  26, -25, -18,   7, -66,   6,  10,  18,  -6, -39, -75,  10;
/M: SY='E';  M=  21, -39, -14,  54, -64, -46, -26, -19,  11, -42, -29, -11, -64,  32,  14,   4,  21, -11, -79, -59;
/M: SY='L';  M= -67, -69, -84, -77, -30, -86, -69, -25, -78,  91, -28, -84, -84, -71, -70, -77, -63, -30, -71, -53;
/M: SY='R';  M=   7, -77, -60, -30, -77,  -2, -12, -61,  48, -60, -34, -33, -67,  44,  76,   1, -59, -59, -75, -64;
/M: SY='D';  M=  -7, -74,  38,  34, -76, -31,   7, -49,  20, -47, -16,   1, -65,  29,  24,  33,  10, -54, -81, -53;
/M: SY='L';  M= -32,  10, -75, -21, -30, -80,  19,  18, -52,  63,  30, -48, -77,   5, -53, -38, -19,  12, -74, -24;
/M: SY='V';  M= -60, -24, -83, -77, -48, -79, -77,  49, -75,  46,  26, -77, -78, -73, -76, -67, -16,  64, -78, -57;
/M: SY='P';  M= -42, -52, -50, -22, -49, -59, -55, -70, -61, -39, -39, -67, 117, -21, -51,   0, -51, -44, -79, -77;
/M: SY='N';  M= -13,   5, -10,   2,  -7,  21, -15, -40, -17,   7, -39,  35,  26,   3, -31,  -1,  26, -52,  -1, -13;
/M: SY='C';  M=   0,  58, -28, -14,   3,   3,  21,  -5, -44,   7,  -4,  20,  10, -36, -59,  10, -10,   5, -26, -16;
/I:         I=-9; MD=-22;
/M: SY='P';  M= -23, -55,  -1, -14, -10, -43,   8, -41, -33, -15, -36,  -4,  51,  -8,  -2,  -3, -40, -36, -39,  22; D=-9;
/I:         I=-9; MD=-22;
/M: SY='N';  M=   8, -88,   6, -21, -73, -10, -55, -25,  -1, -69, -50,  14,   1,   7, -34,  14, -38, -42, -94, -41; D=-9;
/I:         I=-9; MD=-22;
/M: SY='D';  M= -52, -12,  25, -19, -80, -25, -24, -35, -12, -56, -40,  12, -29,   5, -48, -11, -31, -36,-107, -89; D=-9;
/I:         I=-9; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='K';  M= -13, -73, -24,   6, -56,  -7, -17, -54,  37, -48, -38,  -7,  -4,  36,  35,  28,  31, -27, -78, -56;
/M: SY='K';  M= -52, -78, -57, -25, -77, -43,  16, -56,  89, -60, -64, -30,  -9,  15,  48, -33, -55, -55, -75, -64;
/M: SY='L';  M= -14, -26, -55, -39, -49, -37,  -5, -18, -48,  52,  43, -17,   6,   0, -15, -23,  26,   5,  -9, -39;
/M: SY='D';  M= -25, -72,  74,  12, -80, -21, -37, -77, -55, -79, -73,  17,   9, -52, -62,  61,  18, -72, -89, -69;
/M: SY='K';  M= -36, -75, -57, -37, -72, -70, -35, -26,  93, -34, -14, -21, -46,   5,  -2, -49,  18, -35, -73, -25;
/M: SY='A';  M=  58,  -5, -33, -39, -56, -24, -36,  20, -67,  12, -25, -24, -11, -64, -70,   3, -32,  28, -50, -40;
/M: SY='S';  M=   5, -42,  25,  45, -72, -18, -20, -28, -37, -29, -11, -30, -64,  -3, -45,  54,  20,  -7, -82, -67;
/M: SY='I';  M= -60, -71, -78, -75, -39, -82, -20,  73, -61,   6,  45, -69, -72, -47, -74, -63,  43,  40, -78, -57;
/M: SY='L';  M= -65, -69, -84, -77, -17, -86, -69,   6, -77,  83,  17, -82, -83, -71, -75, -76, -62,   9, -71, -37;
/M: SY='R';  M= -31, -52,  34,  38, -56, -19,  -8, -75,  20, -37, -48,   2, -60,  42,  57,  -7, -11, -48, -80, -65;
/M: SY='M';  M= -17,   3,  13,  38, -38, -20,  13, -42,  29,  26,  41, -21, -69,   6,  12, -21, -49, -46, -39, -44;
/M: SY='A';  M=  76, -62, -52, -62, -70, -52, -70, -13, -62, -62, -58, -58, -66, -61, -68,  10,  52,  10, -80, -68;
/M: SY='I';  M=  -8,  12, -77, -72, -39, -79, -15,  67, -22, -18,   0, -68, -73, -39, -26, -44,  23,  53, -79, -52;
/M: SY='D';  M= -18, -50,  53,  37, -78, -35, -22, -50,  22, -60, -24,  35, -65,  25,  14,  26, -14, -51, -83, -52;
/M: SY='Y';  M= -70, -42, -52, -51,  28, -77,  59, -44, -64, -36, -16, -67, -80, -13, -31, -59, -65, -39, -37, 118;
/M: SY='I';  M= -59, -29, -84, -80, -44, -87, -78,  84, -77,  34,  33, -77, -56, -73, -78, -72, -27,  26, -75, -56;
/M: SY='K';  M= -14, -31, -25, -15, -44, -41,   0, -51,  61,  -6, -35,   5, -37,  45,  47, -10, -26, -68,   6, -58;
/M: SY='F';  M=   7, -30,  16,  23,  29, -24,  21, -56,  11, -25,  16, -10, -68,  20, -25,  28, -18, -34,  -8,  15;
/M: SY='L';  M= -45, -70, -79, -58, -45, -66,   4,  -2, -39,  79,  20, -76, -80, -17, -13, -50, -45, -20, -72, -40;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.

Total number of hits	837 in 836 different sequences
Number of true positive hits	837 in 836 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	9
Number of 'partial' sequences	1

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	98.94 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	bHLH
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	836 sequences AHA1_CAEEL (O02219), AHRR_HUMAN (A9YTQ3), AHRR_MOUSE (Q3U1U7), » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	9 sequences BH146_ARATH (Q9SUM5), IBH1_ARATH (Q9SKX1), IBH1_ORYSI (Q01I07), » more
UniProtKB/Swiss-Prot 'Partial' sequences	1 sequence MYCN_DANRE (Q9PSJ0)
PDB [Detailed view]	86 PDB 1A0A; 1AM9; 1AN2; 1AN4; 1HLO; 1MDY; 1NKP; 1NLW; 1R05; 1UKL; 2LFH; 2MH3; » more