PROSITE entry PS50158

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50158
Entry name [info]	ZF_CCHC
Accession [info]	PS50158
Entry type [info]	MATRIX
Date [info]	01-JAN-2002 CREATED; 13-FEB-2019 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50158
Associated ProRule [info]	PRU00047

Name and characterization of the entry

Description [info]

Zinc finger CCHC-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=18;
/DISJOINT: DEFINITION=PROTECT; N1=2; N2=17;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.5831000; R2=0.0164828; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=334.2301331; R2=0.0794979; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=552; H_SCORE=378; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=430; H_SCORE=368; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=0; E1=0; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='R';  M= -9, -6,-18, -7, -5,-19,-11,-10,-15, -1,-15, -7, -4,-13, -1,  2, -5, -7,-11,-25,-13, -4;
/M: SY='K';  M= -6,-10,-24,-11, -5,-19, -8,-13,-16,  4,-14, -7, -6, -7, -3,  4, -6, -6,-12,-23,-14, -5;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Y';  M=-17,-20,-28,-24,-20, 28,-25,  1, -6,-15, -4, -5,-15,-26,-16,-10,-16, -9,-11, 25, 39,-19;
/M: SY='N';  M= -9,  8,-24,  1,  0,-20,-13, -1,-19, 15,-22,-11, 17,-16,  2, 14,  0, -3,-18,-27,-10,  0;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G';  M= -3, -2,-28, -4,-13,-28, 47,-13,-35,-12,-28,-18,  7,-19,-13,-13,  1,-15,-28,-23,-25,-13;
/M: SY='K';  M= -7,  2,-28,  3, 16,-30,-13, -4,-26, 20,-24,-11,  2,-10, 18, 14, -1, -8,-23,-24,-14, 17;
/M: SY='P';  M= -4, -6,-26, -5,  5,-18,-15,-10,-14, -4,-15, -9, -6,  7, -2, -6, -2, -2,-14,-26,-14,  0;
/M: SY='G';  M= -2, -7,-30, -6,-17,-28, 60,-17,-38,-18,-29,-20,  1,-20,-18,-18, -1,-19,-29,-20,-26,-17;
/M: SY='H';  M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='M';  M=-11,-20,-24,-23,-15,  4,-27,-11,  7, -9,  6,  9,-16,-23, -8, -5,-15, -7,  3, -9,  8,-13;
/M: SY='A';  M= 16, -7,-17,-12, -3,-20, -8,-11,-14,  2,-15, -5, -4,-12,  2,  0,  7, -1, -8,-24,-15, -1;
/M: SY='R';  M= -6, -2,-25, -4,  0,-21,-14, -7,-23, 18,-22,-12,  3,-14,  3, 24,  0, -4,-16,-22,-12,  0;
/M: SY='D';  M=-13, 27,-27, 33, 21,-32,-12,  1,-30,  6,-26,-20, 16,-10, 12, -1,  3, -6,-27,-33,-17, 17;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='P';  M= -9,-10,-31, -6,  0,-24,-19,-11,-21,  2,-23,-14, -9, 31, -1,  3, -4, -2,-22,-24,-18, -4;
/M: SY='E';  M= -3,  4,-23,  3, 11,-25,-12, -1,-21,  7,-20,-11,  6,-11, 10,  4,  4, -1,-18,-28,-14, 10;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.

Total number of hits	740 in 460 different sequences
Number of true positive hits	739 in 459 different sequences
Number of 'unknown' hits	0
Number of false positive hits	1
Number of false negative sequences	121
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	99.86 %
Recall (true positives / (true positives + false negatives))	85.93 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	9
Matrix type [info]	protein_domain
Scaling database [info]	window20_shuffled
Author [info]	K_Hofmann, N_Hulo
Feature key [info]	ZN_FING
Feature description [info]	CCHC-type
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	459 sequences AIR1_SCHPO (Q9P795), AIR1_YEAST (P40507), AIR2_YEAST (Q12476), » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	121 sequences CAPSD_CAMVE (Q02951), CLIP1_CHICK (O42184), CLIP1_HUMAN (P30622), » more
UniProtKB/Swiss-Prot False positive sequences	1 sequence EIF3G_EREGS (Q759T4)
PDB [Detailed view]	93 PDB 1A6B; 1AAF; 1CL4; 1DSQ; 1DSV; 1ESK; 1F6U; 1HVN; 1HVO; 1MFS; 1NC8; 1NCP; » more