PROSITE entry PS50157

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50157
Entry name [info]	ZINC_FINGER_C2H2_2
Accession [info]	PS50157
Entry type [info]	MATRIX
Date [info]	01-DEC-2001 CREATED; 07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00028
Associated ProRule [info]	PRU00042

Name and characterization of the entry

Description [info]

Zinc finger C2H2 type domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=28;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=26;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.6689000; R2=0.0207831; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1309.8804932; R2=0.9673913; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=442; H_SCORE=1737; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=345; H_SCORE=1644; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='Y';  M=-19,-21,-24,-25,-21, 39,-28, 10, -2,-17,  2,  0,-17,-28,-19,-13,-18,-10, -7, 12, 48,-21;
/M: SY='K';  M= -4, -5,-23, -5,  6,-20,-18, -9,-14,  7,-15, -7, -5, -9,  3,  2, -2, -2, -9,-25,-12,  4;
/M: SY='C';  M=-10,-20,118,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E';  M= -5,  3,-24,  3,  6,-22,-11, -6,-20,  1,-21,-14,  4, -1,  1, -3,  5,  2,-18,-29,-15,  3;
/I:         I=-12; MI=0; MD=-30; IM=0; DM=-30;
/M: SY='E';  M= -9, -2,-26,  1, 14,-18,-17, -4,-13, -1,-11, -8, -5,-12,  4, -5, -5, -8,-12,-24, -9,  8;
/M: SY='C';  M=-10,-20,119,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-29,-30;
/M: SY='G';  M= -3, -1,-28, -1, -7,-28, 36,-11,-33,-11,-27,-18,  4,-15,-10,-12,  1,-13,-27,-24,-23, -9;
/M: SY='K';  M=-10, -2,-28, -3,  8,-25,-19, -7,-26, 36,-24, -8, -1,-12, 10, 27, -9, -9,-18,-19, -8,  8;
/M: SY='A';  M=  8, -7, -9,-11, -7,-17, -7,-14,-16, -6,-16,-11, -4,-15, -6, -5,  8,  4, -7,-27,-15, -7;
/M: SY='F';  M=-19,-29,-19,-37,-28, 71,-29,-17,  0,-28,  9,  0,-20,-30,-36,-19,-19, -9, -1,  9, 31,-28;
/M: SY='S';  M=  0, -5,-17, -9, -6,-16,-11,-10,-14, -3,-16,-10,  0,-12, -4,  0,  8,  7, -8,-27,-12, -6;
/M: SY='R';  M=-10, -3,-20, -4,  0,-18,-17,  2,-19,  3,-16, -8,  0,-17,  8,  9, -1, -3,-17,-19, -5,  3;
/M: SY='R';  M= -4, -4,-22, -6,  0,-19,-13, -5,-18,  7,-18, -9,  1,-10,  2,  8,  2, -2,-14,-25,-11,  0;
/M: SY='S';  M=  2, -1,-16, -1, -1,-18, -4, -6,-19, -7,-22,-14,  4,-12, -2, -7, 16,  7,-13,-29,-12, -2;
/M: SY='N';  M= -5,  5,-20,  1,  0,-18,-10,  8,-18, -5,-18,-11,  9,-16,  1, -4,  4, -1,-17,-27, -7, -1;
/M: SY='L';  M=-11,-29,-20,-30,-20, 12,-29,-19, 17,-27, 43, 18,-28,-29,-20,-18,-28,-10,  9,-18,  2,-20;
/M: SY='R';  M= -6, -6,-22,-10, -4,-15,-20, -8, -7,  2, -9, -3, -2,-16,  0,  3, -3,  0, -6,-24, -8, -3;
/M: SY='R';  M= -6, -6,-23, -7,  0,-19,-17, -7,-14,  7,-13, -6, -2,-16,  4, 12, -3, -3,-10,-24,-10,  0;
/M: SY='H';  M=-20,  0,-30,  0,  0,-20,-20, 99,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='Q';  M=-10,-10,-25,-12,  1,-16,-22, -2, -6,  1, -3,  6, -9,-17, 13,  3, -9, -8, -9,-19, -4,  6;
/M: SY='R';  M=-13, -8,-26, -9,  0,-19,-19, -4,-21, 20,-16, -6, -2,-17,  6, 35, -8, -7,-14,-21, -9,  0;
/I:         I=-12; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='V';  M= -3,-16,-17,-21,-17, -6,-25,-20, 11,-15,  2,  3,-12,-18,-14,-14, -2,  9, 13,-25, -7,-17;
/M: SY='H';  M=-20,  0,-30,  0,  0,-20,-20, 97,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 19,  0;
/M: SY='T';  M=  1, -2,-13, -8, -6,-14,-15,-15,-12, -7,-13, -9,  0,-12, -6, -8, 14, 25, -5,-29,-12, -6;
/M: SY='G';  M= -3, -4,-27, -4, -8,-27, 34,-14,-32, -9,-25,-16,  2,-15,-10, -9,  0,-13,-24,-23,-23,-10;
/M: SY='E';  M= -9,  6,-27, 12, 33,-26,-17, -3,-24,  7,-18,-15, -1, -6, 12,  0, -2, -8,-22,-28,-16, 22;
/M: SY='K';  M=-11, -1,-28, -2,  6,-25,-17, -6,-27, 32,-25,-10,  1,-11,  8, 28, -7, -8,-19,-22,-11,  6;
/M: SY='P';  M= -7,-14,-32, -9, -1,-24,-17,-15,-18, -7,-23,-15,-13, 51, -7,-13, -6, -6,-23,-28,-22, -7;
/I:         E1=0;

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Post-processing [info]

COMPETES_HIT_WITH

PS51810; PS51811; PS51905; PS51906; PS51907; PS51908

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.

Total number of hits	13'969 in 2'074 different sequences
Number of true positive hits	13'957 in 2'062 different sequences
Number of 'unknown' hits	4 in 4 different sequences
Number of false positive hits	8 in 8 different sequences
Number of false negative sequences	216
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	99.94 %
Recall (true positives / (true positives + false negatives))	98.48 %

Comments [info]

Taxonomic range [info]	Archaea, Bacteriophages, Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	38
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	K_Hofmann
Feature key [info]	ZN_FING
Feature description [info]	C2H2-type
Version [info]	9

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	2062 sequences A45_SSV1(P20198), ABRU_DROME (Q24174), ACE1_HYPJE (Q9P8W3), » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	216 sequences ANKZ1_BOVIN (Q58CQ5), ANKZ1_HUMAN (Q9H8Y5), ANKZ1_MOUSE (Q80UU1), » more
UniProtKB/Swiss-Prot 'Unknown' sequences	4 sequences CPXCR_HUMAN (Q8N123), CPXCR_MACFA (Q4R6N4), DUS12_HUMAN (Q9UNI6), RBM10_RAT (P70501) » more
UniProtKB/Swiss-Prot False positive sequences	8 sequences BRE1_YEAST (Q07457), I17RD_MOUSE (Q8JZL1), TERM_DROME (P11455), » more
PDB [Detailed view]	503 PDB 1A1F; 1A1G; 1A1H; 1A1I; 1A1J; 1A1K; 1A1L; 1AAY; 1ARD; 1ARE; 1ARF; 1BBO; » more