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PROSITE entry PS50142


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50142
Entry name [info] RNASE_3_2
Accession [info] PS50142
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00448
Associated ProRule [info] PRU00177

Name and characterization of the entry

Description [info] Ribonuclease III family domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=124;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=119;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.2496000; R2=0.0182516; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=6947.5546875; R2=6.2195892; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=453; H_SCORE=9765; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=343; H_SCORE=9081; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 620 in 567 different sequences
Number of true positive hits 620 in 567 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 4
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.36 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] RNase III
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
567 sequences

A464_PBCV1  (Q98514), DCL1_ARATH  (Q9SP32), DCL1_ASPCL  (A1CBC9), 
» more

UniProtKB/Swiss-Prot
False negative sequences
4 sequences

RM44_BOVIN  (Q2KIS2), RM44_HUMAN  (Q9H9J2), RM44_MOUSE  (Q9CY73), 
» more

PDB
[Detailed view]
143 PDB

1I4S; 1JFZ; 1O0W; 1RC5; 1RC7; 1YYK; 1YYO; 1YYW; 1YZ9; 2A11; 2EB1; 2EZ6;
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