PROSITE entry PS50127

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50127
Entry name [info]	UBC_2
Accession [info]	PS50127
Entry type [info]	MATRIX
Date [info]	01-DEC-2001 CREATED; 12-AUG-2020 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00163
Associated ProRule [info]	PRU00388

Name and characterization of the entry

Description [info]

Ubiquitin-conjugating (UBC) core domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=149;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=144;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1424074; R2=0.0078338; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1004; N_SCORE=10.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=557; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-26; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P';  M=  13, -73,   8, -55, -27, -64, -16,  -6,  -2, -44,  18,  29,  45,  38, -31,  30, -14,  -1, -80, -65;
/M: SY='C';  M=  47,  49, -67, -42, -35, -64, -65,   1, -28, -32, -17, -31, -72,  28,  45,  19, -40,  -9,   8, -64;
/M: SY='S';  M= -28, -73, -10,  10, -33, -18,   4,  23, -31,  -6, -10,  22, -40,  25, -11,  27,  24,   0, -79, -22;
/M: SY='R';  M= -47, -76, -25, -56,  21, -73, -57, -11,  50,  -8, -57, -25, -72, -13,  53,   7,   6, -62, -64,  46;
/M: SY='R';  M= -48, -81, -62,  -1, -42, -77,  -3, -75,  15, -10, -61, -58, -74, -43, 101, -61, -14, -71, -76, -62;
/M: SY='L';  M= -65, -72, -86, -80,  -6, -88, -75,  52, -79,  69, -33, -82, -82, -74, -78, -75, -61,  29, -73, -54;
/M: SY='M';  M=   9, -72, -67, -16, -35, -72,  13,  -3,  16,  33,  66, -62, -71,  49,  -8, -17, -18, -18, -73, -23;
/M: SY='K';  M=   1, -74, -21,   5, -77, -35, -56, -76,  78, -56, -29,  24, -65,  12,  35,  -4, -16, -71, -76, -66;
/M: SY='E';  M= -62, -81,  48,  99, -84, -74,  -3, -85, -42, -77, -73, -52, -58,  -3,   2, -56, -60, -78, -83, -71;
/M: SY='Y';  M= -65, -73, -76, -42,  19, -80, -58,  12, -69,  52,  -9, -74, -80, -66, -17,  -8, -41,   0,  13,  79;
/M: SY='K';  M=   8, -12, -29,  35, -74, -66, -55, -69,  49, -34,  32,  39, -67,  16,  45, -22, -57, -39, -78, -66;
/M: SY='E';  M=   0, -74,  35,  49, -73, -66,  10, -39,  -1, -13,  11,  15, -66,  16,  22,  17,  -5, -39, -82, -65;
/M: SY='L';  M= -63, -72, -83, -78,  -9,  12, -72,  42, -76,  61,  45, -76, -78, -71, -76, -71, -62,  10,  45, -53;
/I:         I=-45; MD=-115;
/M: SY='Q';  M= -21, -13,   1,  43, -70, -69, -55, -47,   0, -18,  40,  -2, -21,  69,   5,   0,  -9, -41, -75,   4; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='K';  M= -18, -73, -31,   8, -70, -25, -57, -40,  63, -17,   5,  27, -67,  17,  21,  16,  -1, -35, -75, -18;
/I:         I=-25; MD=-63;
/M: SY='N';  M=  -2, -74,  29,  52, -78,   9, -18, -76,  -9, -44, -11,  58,   1, -12, -58,  18, -27, -73, -84, -71; D=-25;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='P';  M=  -3, -79,  15,  31, -72, -29, -20, -36,  13, -15, -62,  -3,  70,  32,  -7, -57, -32, -28, -76,  -1;
/I:         I=-38; MD=-97;
/M: SY='P';  M= -21, -12, -40, -12, -67,  11, -10,   3, -33,   8, -21, -29,  65,  -2, -37,   9,  -1,   4, -78, -24; D=-38;
/I:         I=-38; MD=-97;
/M: SY='P';  M= -26,  23,  20,  19,  -8, -14, -63, -25,  30, -73, -67,   5,  58,   4, -57,  22, -31, -25, -80, -69; D=-38;
/I:         I=-38; MI=-97; MD=-97; IM=-97; DM=-97;
/M: SY='G';  M= -36,  28,  23, -45, -36,  63,   4, -57, -33, -43, -70,  48, -71, -40, -68,  15, -17, -45, -81, -26; D=-38;
/I:         I=-38; DM=-97;
/M: SY='I';  M= -42,  43, -27, -45,  48, -47, -13,  66, -73,   4,  11, -69, -29, -72, -75, -15,  -8,   6, -68, -10;
/I:         I=-42; MD=-106;
/M: SY='Y';  M= -17, -74, -10, -38,  -4, -38, -17,  13,  -6, -23,   6, -17, -72,  14,   0,  11,  22,   0,  15,  67; D=-42;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='V';  M=  29, -27, -37, -68, -57, -26, -11,  23, -38,  11,  10, -37, -73, -26, -31,  -4, -15,  56, -78, -15;
/M: SY='W';  M= -11, -14,  10,   3,   5, -20,  12,  23,   2,  11, -53,  19, -72, -57,  23, -41,  -9, -22,  45,  16;
/M: SY='P';  M= -39, -25, -66, -17, -31, -20, -66,  -1, -34,   1, -18, -33,  86,  -6, -35, -16,  22,  -2, -73,  12;
/M: SY='V';  M= -18, -11,  36, -10, -32, -66,   7, -18, -13, -15,  -9,  31,  -8, -57, -34,  34, -17,  37, -80,   3;
/M: SY='E';  M=  -9, -15,  52,  56, -32, -33, -56, -76, -35, -76, -70,  21,  50, -50, -30,  17, -36, -73, -77,  20;
/M: SY='D';  M= -17, -74,  70,  44, -77, -23,  -8, -41, -26, -30, -68,  28, -28, -16, -59,  29,   4, -45, -87, -68;
/I:         I=-24; MI=0; MD=-60; IM=0; DM=-60;
/M: SY='N';  M= -58,  -3,  64, -49, -76, -28, -51, -77, -16, -79, -71,  81, -69, -52,  -2,  35,  17, -74, -89, -20;
/M: SY='M';  M= -13,  -7, -79, -72,   8, -40, -68,  52, -40,  40,  62, -71, -37,  -6, -40,  -7, -59,  -2, -12, -20;
/M: SY='F';  M= -36, -71,   4, -35,  46, -72, -59, -51, -22,  39,  29, -61, -74,  13,  -2,  23,  23, -54, -64,  28;
/M: SY='H';  M= -63, -76,  12,  50, -28, -72,  64, -20,  16,   3, -56,  21, -68,  21,   6, -31, -21, -11, -78,  -2;
/M: SY='W';  M= -72, -89, -91, -38,  34, -76, -11, -19, -41, -20, -62, -85, -79, -71, -73, -48, -77, -11, 161,  -8;
/M: SY='H';  M= -33, -75, -16,  21,  17, -69,  82, -10,  18, -29, -57,  24, -33,  12,  -9, -10,   5, -31,  15,   9;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='V';  M=  28,  25, -72, -21,  20,  39, -16,   4, -69, -15, -12, -66, -74, -68, -72, -58, -59,  43, -68,  30;
/M: SY='V';  M= -11, -70, -37,   1, -36, -49,  -3,  30, -15,  16,  21, -14, -72, -10, -66, -59,  26,  52, -78, -22;
/M: SY='I';  M= -46, -75, -83, -80,  31, -86, -78,  89, -75,   7,   8, -75, -76, -74, -41, -71, -13,   8, -68, -15;
/M: SY='F';  M= -48, -72, -14,  15,  43, -75, -13,  17,  22,  10, -28, -32, -37,  -8,  -4,   1,  13,  15, -69, -16;
/I:         I=-45; MD=-115;
/M: SY='G';  M= -55, -80, -24, -76, -82,  88, -74, -40, -34, -42, -73, -56, -73, -69, -43, -18, -33, -25, -80, -78; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='P';  M= -10, -84, -67, -57, -77, -32,  -6, -32, -39, -33, -14, -35, 109, -18,   0, -36, -58, -10, -79, -74;
/M: SY='D';  M= -34, -78,  52,  51, -33,  -6,  -3, -73, -17, -74,  -9, -21,  47,  17, -29,  20, -19, -28, -82, -68;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='D';  M= -57, -77,  66,  21, -82,  56,  -4, -51, -54, -81, -73,  40, -67, -10,   4,   0, -58, -79, -85, -71;
/M: SY='T';  M= -50, -65, -20, -61, -26,  17, -65, -31, -59, -29, -61, -48, -33, -28, -66,  50,  88, -56, -82, -65;
/I:         I=-25; MD=-63;
/M: SY='P';  M= -22, -83, -73, -39, -17, -50, -70,  18, -69,   1,  -2, -26,  92, -26, -75, -67, -61,   7, -74,  15; D=-25;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='Y';  M= -37, -81, -71, -33,  34, -77,   1, -57, -66, -53, -51, -72, -82, -62, -64, -66, -66, -62,  48, 125;
/M: SY='E';  M=  33, -76,  18,  80, -81, -41,  24, -79,   2, -74, -68, -27, -61,  29,   1, -52, -59, -71, -80, -68;
/M: SY='G';  M= -54, -75,  31,  -2, -78,  79, -60, -82, -40, -55,  -6,  54, -68, -58, -67, -25, -60, -79, -79, -31;
/M: SY='G';  M= -42, -76, -60,   9, -77,  87, -11, -84, -16, -41, -70, -51, -68, -58,  13,   3, -64, -78, -74, -31;
/M: SY='V';  M=  -5,  -3, -71, -66,  10, -75,   0,  31,   3,   7,  22, -33, -73,   6,  -6, -38,  27,  37, -72,   8;
/M: SY='F';  M= -74, -77, -32, -78, 100, -80, -59, -34, -73, -33, -52, -75, -22, -77, -72, -72, -68, -58,  77,  78;
/M: SY='H';  M= -33, -75, -60, -17,  18, -71,  60, -63,  33, -12,  10,  -6, -71,  41,  46,   0, -20, -14, -71,  10;
/M: SY='F';  M=  12, -70, -81, -77,  71,  11, -70,  21, -75,  46, -10, -73, -79, -74, -75, -66, -62, -10, -61, -43;
/M: SY='Q';  M= -34, -73,  27,  13, -69, -67,  26, -66,  31,  -1,   2,  12, -67,  42,   9,  22,  23, -41, -79, -19;
/M: SY='I';  M= -64, -73, -85, -81,  26, -87, -77,  82, -77,  25,  50, -77, -77, -74, -78, -73, -59,  26, -70, -51;
/M: SY='H';  M= -61, -75,  -6,  25,  19, -71,  43,   4,  15,  -7, -56,  16, -69,  36,  21,   3,  19, -38, -74, -13;
/M: SY='F';  M= -67,  56, -84, -80,  86, -83, -72,  23, -77,  36, -43, -26, -84, -80, -77, -72, -62,  18, -59, -38;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='P';  M= -63, -84,   5, -54, -83,   5, -25, -75,   0, -82, -70,  -1, 109, -61, -35, -22,  -3, -77, -81, -78;
/M: SY='D';  M=   0, -75,  63,  35, -73, -63, -57, -32, -15, -55, -68,  17,  32, -27, -32,  32,  -5, -41, -80,   9;
/M: SY='N';  M= -22, -74,  62,  32, -79, -28,  17, -46, -10, -76, -69,  64, -36,  20,  -4, -15,  10, -48, -88, -68;
/M: SY='Y';  M= -72, -79, -71, -74,  54, -77,   9, -56, -67, -52, -50, -12, -83, -64, -64, -66, -65, -61, -31, 123;
/M: SY='P';  M= -66, -90, -64, -55, -85, -67,   8, -74, -62, -84, -70,   4, 124, -65, -73, -62, -58, -79, -81, -80;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='F';  M= -30, -73,   7,  11,  65, -72, -12,   8, -64,   2,  38,  25, -75, -62, -66,  -2, -59, -29, -57,  55;
/M: SY='K';  M=  12, -71,  19,  19, -73, -34,  -9, -35,  44, -34, -25,   8, -66,  -9,   4,  42, -22,  -3, -80, -66;
/M: SY='P';  M=   2, -82, -27, -56, -80, -64, -68, -24, -62, -47, -67, -66, 113, -63, -72,  28, -54, -69, -79, -77;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='P';  M= -66, -91, -67, -56, -84, -68, -70, -72, -63, -49, -69, -73, 127, -67, -75, -64, -59, -78, -79, -82;
/M: SY='T';  M= -23, -70, -58, -33,  11, -40, -15, -16,  52, -65, -60,  15, -66,  16,   2,  29,  52, -12, -76, -60;
/M: SY='V';  M= -58,   7, -84, -79,  14, -53, -80,  50, -76,   6,  33, -77, -78, -76, -77, -69, -55,  76, -77, -55;
/M: SY='R';  M= -33,  25, -64, -37, -64, -22,  21,   4,  45, -30,  18, -31, -70, -19,  53, -14,  16,   1, -74,   8;
/M: SY='F';  M= -71,  53, -86, -81, 106, -81, -66, -47, -76, -19,  55, -75, -84, -82, -74, -72, -65, -11, -48,   9;
/M: SY='T';  M= -39,  -5, -15, -40, -59, -76,  23,  23, -12,  23,  10, -61, -71,  38, -63, -28,  42,  41, -81, -59;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='T';  M= -52, -65, -55, -16, -71, -42,   6, -65, -17, -68, -63,  11,   5,   2, -61,  32,  94, -58, -86, -66;
/M: SY='P';  M= -44, -79,  -8,  14, -16, -42, -61, -25,  47, -72, -65, -23,  73,  -3,  34, -57,  19, -36, -77, -67;
/I:         I=-16; MI=0; MD=-41; IM=0; DM=-41;
/M: SY='I';  M= -68, -82, -82, -76, -60, -87,  -5,  76, -68, -35,  38, -75,  30, -70,  26, -73, -32,  16, -81, -63; D=-16;
/I:         I=-16; DM=-41;
/M: SY='W';  M= -49, -79, -80, -36,  71, -81, -66,   8, -20,   8,  -5,  -6, -51, -33, -71, -73, -68, -15,  81,  56; D=-16;
/I:         I=-16; DM=-41;
/M: SY='H';  M= -65, -77, -50,  -2, -68, -66, 132, -78, -56, -43,  15,  49, -69, -48, -54,  -4, -61, -79, -97, -44;
/M: SY='P';  M= -16, -10, -66, -58, -82,  11, -69, -72, -28, -79,   8, -67, 114, -64, -72, -15, -29, -74, -79, -79;
/M: SY='N';  M= -62,  19, -43, -21, -74,  -1,  67, -75, -49, -51, -65, 104, -73, -51,  15, -49, -53, -41, -92, -64;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='I';  M= -61, -72, -85, -81,  33, -87, -81,  73, -77,   9, -38, -78, -78, -77, -79, -71, -57,  64, -73, -52;
/M: SY='Y';  M= -43,  37,  58, -18, -53, -25,   0, -66, -17, -41,  -3,  44, -73, -56, -32,  11, -30, -25, -65,  75;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='P';  M= -12, -11,  -5,  44, -74, -34, -58, -45,  -3, -38, -24,  26,  56, -23,  -6,  38,   4, -68, -80, -26;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='N';  M= -46,  17,  43,  -8, -27, -14,  -9, -71, -11, -57, -66,  71, -69,  25, -58,  18,  24, -37, -81,  13;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='G';  M= -50, -75, -62, -71, -81,  95, -69, -86, -22, -83, -73, -16, -67, -64, -23, -27,   9, -80, -75, -76;
/M: SY='H';  M=  -1, -74,  -1,  28, -75, -28,  45, -73,  40, -50,  -8,  37, -66,  -3,  40,  12, -16, -40, -81, -63;
/I:         I=-42; MD=-106;
/M: SY='I';  M= -61, -74, -84, -80, -53, -86, -84,  77, -77,  -8,  -8, -76, -31, -75, -80, -34,  -7,  58,  33, -59; D=-42;
/I:         I=-42; MD=-106;
/M: SY='C';  M= -66, 143,  -1, -39, -77, -80, -81, -40, -78, -74, -73, -24, -92, -83, -85, -52, -65, -70,-104, -85; D=-42;
/I:         I=-42; MI=-106; IM=-106; DM=-106;
/M: SY='L';  M= -23, -70, -80, -73, -46, -81, -10,  14, -36,  73,  51, -76,  -4, -67, -71, -70,  -6, -15, -74, -55;
/M: SY='S';  M= -39, -71,  67,   6, -79, -57,  -4, -78, -52, -79, -73,  44, -13, -49,   1,  68, -14, -73, -89, -68;
/M: SY='I';  M= -30, -72, -80, -77, -23, -31, -76,  75, -36,  33,  26, -26, -76, -71, -75, -34, -57,  32, -75, -57;
/M: SY='L';  M= -39, -69, -78, -73, -18, -41, -69,  31, -72,  73, -35, -72, -78, -67, -31,  14,  -2, -40, -72, -55;
/M: SY='H';  M= -60, -77,  33,  -4, -76,  18,  57, -79,  37, -77, -67,  10,  14,  14,  32,   5,   4, -76, -80, -22;
/I:         I=-21; MD=-53;
/M: SY='W';  M= -16,  19, -91, -16,  18, -97, -90, -41, -88, -65, -16, -37, -26, -10, -92, -81,  18, -43,  32,   6; D=-21;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='P';  M= -40, -97, -48, -43,  17,  -2, -84, -82,  -5,  -2, -77, -37,  51, -10, -40, -51, -44, -84, -90, -78; D=-21;
/I:         I=-21; DM=-53;
/M: SY='E';  M= -35, -78,  49,  68, -79, -51, -54, -78,   8, -76, -28,  -5,  12,  21,  18,   2,  -4, -74, -80, -21;
/M: SY='D';  M= -12, -73,  37,  23, -78,   9,  23, -76,  32, -76, -68,  30, -65,  -1,  21,  16,  21, -49, -83, -66;
/M: SY='W';  M= -75, -99, -99, -79, -22, -74, -95, -73, -69, -70, -72, -93, -79, -70, -19, -81, -86, -86, 175,  12;
/M: SY='S';  M= -12, -68, -54, -54, -72, -59, -57, -34,  24, -38, -63,  46, -66,   2,  31,  61,  42, -63, -81, -66;
/M: SY='P';  M= -15,  -6, -62, -55, -82, -64, -65, -74,  -9, -81, -69,   7, 108, -59,  14,  18, -29, -74, -80, -77;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='A';  M=  46, -67, -62,  -3, -29,  -9, -62, -35, -37, -18,  32,  28, -69,   6, -64,  16,  -2,  27, -76,  -3;
/M: SY='W';  M= -65, -14, -66,  13, -44, -75,  29,  -9, -60,  23,  18, -15, -75,  23, -13, -18, -20, -34,  91,  73;
/M: SY='S';  M= -53, -68,  31, -52, -74, -38,  20, -69,   6, -73, -30,  51, -65,  -4, -29,  63,  46, -26, -87, -65;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='I';  M= -62, -71, -81, -77, -48, -84, -74,  60, -75,  49,  48, -32, -17, -71, -76, -70, -20,  42, -76, -57;
/M: SY='W';  M= -29, -11, -34,  45, -62, -69, -59, -10,   3,  -5, -14, -27, -68,  42,  23,  27, -28, -64,  81,  12;
/M: SY='Q';  M= -10, -69,   5, -32, -74, -36,  41, -68, -30, -46, -62,  20, -65,  57, -57,  53,  55, -35, -84, -63;
/M: SY='V';  M= -10,  11, -83, -79,  -8, -83, -83,  67, -76,  -8, -40, -76, -77, -76, -78, -67, -55,  73, -79, -58;
/M: SY='L';  M= -64,  49, -84, -78, -17, -85, -73,  38, -77,  70,   3, -80, -82, -73, -77, -74, -60,  25, -74, -55;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='W';  M= -63, -74, -69,   0, -53, -79,  13,  26,  12,  42,  32, -31, -73,  12,  -4, -65,  -1,  18,  49, -20;
/M: SY='S';  M=  13,  -7, -25, -28,  -8,  43, -59, -72, -31, -71, -13, -51, -67,  28, -62,  63, -13, -67, -69,  32;
/M: SY='I';  M= -37, -72, -84, -79,   8, -85, -75,  74, -77,  51,  29, -77, -78, -72, -77, -36, -59,   7, -71, -53;
/M: SY='Q';  M= -33, -37, -66, -54, -62, -74, -60,  31,   9,  20, -48, -10,  -4,  78,  19, -29, -59,   7,  11, -18;
/M: SY='S';  M=  29, -15, -62, -38,   7,  -1, -62, -61, -12, -42, -20,  -7, -69,  13,   5,  62, -20,   8, -74, -20;
/M: SY='L';  M= -65, -70, -77,  -2,  22, -83, -67,  26, -72,  68,  55, -76, -78, -67, -72, -32, -26, -14, -70, -51;
/M: SY='M';  M= -66, -70, -84, -76,  57, -82, -66,  10, -24,  57,  84, -76, -79, -69, -70, -73, -62,  -3, -64, -44;
/M: SY='S';  M=  11,  35, -35, -27,  -7, -30, -18, -36, -32,   7,  28,  24, -32, -57,  -2,  43,   9, -13, -74,  15;
/M: SY='D';  M= -34, -19,  61,  50, -76, -40,   3, -75,  16, -75, -70,  21, -64, -21, -54,  40,  -2, -29, -84, -19;
/M: SY='P';  M= -30,   9, -12, -31, -33, -15, -65,  -8, -16, -34, -65,  13, 100, -61, -68,  18, -55, -68, -78, -36;
/I:         I=-20; MI=0; MD=-51; IM=0; DM=-51;
/M: SY='N';  M= -36, -74,  23,  41, -70, -63, -50, -67,  -2, -48, -65,  83,  15,  28, -55, -52, -54,  -2, -79,  22;
/M: SY='P';  M= -14, -75,  -9, -62,  15,   8, -63, -14,  -8, -13,  17,  14,  63, -62,   0,  -4,  11, -23, -73,  -1;
/M: SY='D';  M= -43, -76,  49,  39, -42,  -6,  -7, -78,  17, -62, -70,  37, -66,  -4,  22,  22,  -3, -74, -81,  -5;
/M: SY='D';  M= -27, -75,  68,  11, -13, -16,   2, -31, -13, -17, -65,  15, -32, -19, -10,  35, -29, -18, -84, -64;
/M: SY='P';  M=  -1, -82, -66, -16, -77, -14, -68, -65, -63, -20,   6, -31, 105, -17, -72,  -4, -58, -14, -79, -76;
/M: SY='L';  M=  19, -71, -37, -35,  -8,   2, -66, -32, -16,  45, -48, -64,  -4,  32, -24,  16, -57,   1, -74, -60;
/M: SY='N';  M= -22, -74,  32, -54, -73,  -8, -52, -12, -23, -73, -31,  88,  22,  20, -18, -31, -23, -29, -83,   2;
/M: SY='P';  M=  18, -23, -35,  -1, -12, -42, -68,  -2, -11, -29,  -5,  21,  54, -62, -35, -13,   0,  39, -80, -66;
/M: SY='E';  M= -42, -77,  62,  63, -18, -67, -55, -76,   7, -75, -70,  29, -64,  36, -54,  -5,   0, -33, -84, -67;
/M: SY='A';  M=  56, -69, -66, -15, -65,  -5, -14,  17, -30, -14, -28, -61, -22, -20, -34,  28, -15,   2, -75,  -6;
/M: SY='A';  M=  65, -68, -33, -31, -67,   2, -62, -67, -32, -43, -62,  -7, -31,   1, -11,  28,   1, -40, -72,  28;
/M: SY='E';  M= -42, -77,  22,  45, -73,  -8,  -5, -68,  23, -48, -12,  13, -67,  28,  34, -25,  10,  -2, -79, -11;
/M: SY='M';  M= -62, -73,   0,  20, -21, -49,  11,   7, -19,  35,  55, -63, -71,   1, -17, -42,  31,  -9, -74,   8;
/M: SY='Y';  M=  -6, -17, -28, -38,  29, -45, -12, -31, -22,  29, -11,  -5, -29,  18, -32, -30,  -1, -57,  45,  69;
/M: SY='R';  M= -21,  33, -65, -58, -68, -24,  -7, -40,  33,   0,  -7,  -5, -73,  13,  52,  14,   2,  -4, -78, -19;
/M: SY='K';  M= -22,   3,  17,  27, -79, -22, -60, -28,  35, -51, -68,  22, -29,  35,  20, -13,  13, -52, -83, -39;
/I:         I=-24; MD=-60;
/M: SY='N';  M= -26, -78,  62, -29, -79,   4, -11, -77,  -5, -10, -71,  68, -75, -57,   5, -28, -34, -77,  -5, -71; D=-24;
/I:         I=-24; MI=0; MD=-60; IM=0; DM=-60;
/M: SY='R';  M= -64, -82, -18,   5, -74, -44, -26, -75,  31, -58, -14,  20,  42,  11,  45,  16, -43, -36,  33,   0;
/M: SY='P';  M= -29, -81,  27,  33, -47, -23, -64, -46,  21, -29, -20, -59,  43,  21,   2,  -7,  -9, -15,   2, -26;
/M: SY='E';  M= -21, -17, -30,  53, -74, -17, -63, -67,  11, -11,   6, -24, -25,  13,  -1,  29, -31,  -5,   2, -69;
/M: SY='Y';  M= -34, -80, -80, -80,  77, -82,  -2, -57, -74, -29, -54, -76, -87, -74, -72, -71, -21, -41, -41, 101;
/M: SY='N';  M=  -9, -79,   6,  27, -48, -45, -16, -13,  21, -40, -67,  46, -40, -18,  29, -10, -20, -21, -84, -26;
/M: SY='K';  M= -10,  -9, -21,  17, -80, -41,  22, -81,  41, -62, -28,  13, -71,  22,  37,  19, -15, -76,   7, -68;
/M: SY='K';  M= -47,  16, -35,  -6, -69, -78, -65,  13,  39,  14,   1,  22, -34, -19,  36, -63,  12, -60, -83, -68;
/M: SY='V';  M=  34, -72, -81, -44,  12, -33, -80,  13, -76, -16, -52, -37, -80, -75, -78, -64, -34,  66, -80, -23;
/M: SY='R';  M= -69, -19, -61,   9, -35, -76,   1, -24,  30, -32,   5,  28,  -9,  33,  66, -46, -65, -73, -82, -67;
/M: SY='E';  M= -33, -27,  27,  59, -27, -79,  17, -21,  -6,  -3,  -3, -21, -72,  -8, -21, -38, -12, -52, -84, -10;
/M: SY='W';  M= -47,  17, -36, -22,  35, -80,  35, -39, -40,  -1, -17,  -3, -82,  17, -22, -43,   6, -47,  66,  51;
/M: SY='M';  M= -16,  37, -76, -12, -64, -82, -77,  27, -40,  -6,  38, -31, -78, -71, -39, -37,  37,  37, -87, -32;
/M: SY='M';  M= -24, -80, -14,  16, -35, -75, -65, -19,  33, -32,  43, -14, -75,  -4,  31,  21, -61,  -8, -82, -34;
/M: SY='K';  M= -21, -84,  -3,   5, -79, -10, -14, -48,  52, -22, -69, -20, -30,  22,  27, -42,  -9, -75, -82, -14;
/M: SY='Y';  M= -32,  -6, -71, -24,  21,  12,  36, -46, -27, -33,   6,  -8, -80, -66, -34,  21, -20, -41,  18,  57;
/M: SY='W';  M=  45,  13,  -8, -34, -76, -30,  12, -30,   0, -30,   5, -34, -36,  -3,  -8,  -6, -34, -42,  57, -69;
/M: SY='M';  M= -14, -80, -43,  -6,  -4, -22, -18, -24,  -5, -15,  39,   5, -40,   5, -16, -22,  10,  11, -81,   0;
/I:         E1=0; IE=-380; DE=-380;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.

Total number of hits	370 in 370 different sequences
Number of true positive hits	370 in 370 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	UBC core
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

370 sequences

AKTIP_AEDAE (Q17PP1), AKTIP_ANOGA (Q7PRH1), AKTIP_CHICK (Q5ZJJ5),

AKTIP_CULQU (B0X6E8), AKTIP_DANRE (Q7ZYX1), AKTIP_HUMAN (Q9H8T0), 
AKTIP_MACFA (Q4R5E1), AKTIP_MOUSE (Q64362), AKTIP_NEMVE (A7RRG3), 
AKTIP_PONAB (Q5RE48), AKTIP_RAT   (Q5FVH4), AKTIP_SALSA (B5X1G6), 
AKTIP_XENTR (Q28IA3), AKTP1_DROAN (B3MEZ6), AKTP1_DROER (B3N6U7), 
AKTP1_DROGR (B4J613), AKTP1_DROME (Q7K4V4), AKTP1_DROMO (B4KMF8), 
AKTP1_DROPE (B4H581), AKTP1_DROPS (Q28XA5), AKTP1_DROSE (B4HT57), 
AKTP1_DROSI (B4QHS6), AKTP1_DROVI (B4LNV5), AKTP1_DROWI (B4MQY1), 
AKTP1_DROYA (B4NWM2), AKTP2_DROAN (B3MGT3), AKTP2_DROER (B3NK72), 
AKTP2_DROGR (B4JWF5), AKTP2_DROME (A1ZBR5), AKTP2_DROMO (B4KS18), 
AKTP2_DROPE (B4GD81), AKTP2_DROPS (Q28YD9), AKTP2_DROSE (B4HPU1), 
AKTP2_DROSI (B4QEJ9), AKTP2_DROVI (B4LPP8), AKTP2_DROWI (B4MRW2), 
AKTP2_DROYA (B4PAP8), AKTPA_XENLA (Q498F8), AKTPB_XENLA (Q5XGV8), 
BIRC6_HUMAN (Q9NR09), BIRC6_MOUSE (O88738), COP10_ARATH (Q9LJD7), 
MMS2_SCHPO  (O74983), MMS2_YEAST  (P53152), PEX4_ARATH  (Q8LGF7), 
PEX4_GIBZE  (I1RRW0), PEX4_KOMPG  (C4R826), PEX4_PICPA  (P49428), 
RCE1_ARATH  (Q9SDY5), SCE1_ARATH  (Q42551), U2D2B_MOUSE (Q6ZWY6), 
U2D2B_RAT   (P70711), U2D2L_HUMAN (Q8IWF7), U2QL1_DROME (Q9VM35), 
U2QL1_HUMAN (A1L167), U2QL1_MOUSE (A0PJN4), UB12L_ARATH (Q9ZU75), 
UB2D1_BOVIN (Q2TA10), UB2D1_HUMAN (P51668), UB2D1_MOUSE (P61080), 
UB2D1_RAT   (D3ZDK2), UB2D2_BOVIN (Q1RMX2), UB2D2_HUMAN (P62837), 
UB2D2_MOUSE (P62838), UB2D2_PIG   (Q06AA9), UB2D2_RAT   (P62839), 
UB2D2_XENLA (P62840), UB2D3_BOVIN (Q3ZCF7), UB2D3_HUMAN (P61077), 
UB2D3_MACFA (Q4R5N4), UB2D3_MOUSE (P61079), UB2D3_PONAB (Q5R4V7), 
UB2D3_RAT   (P61078), UB2D4_HUMAN (Q9Y2X8), UB2D4_XENLA (A5PKP9), 
UB2E1_HUMAN (P51965), UB2E1_MOUSE (P52482), UB2E2_HUMAN (Q96LR5), 
UB2E2_MOUSE (Q91W82), UB2E3_BOVIN (Q2T9X7), UB2E3_HUMAN (Q969T4), 
UB2E3_MOUSE (P52483), UB2FA_MOUSE (Q9CY34), UB2FB_MOUSE (Q3UWQ3), 
UB2G1_HUMAN (P62253), UB2G1_MACFA (Q4R5Y8), UB2G1_MOUSE (P62254), 
UB2G1_RAT   (P62255), UB2G2_BOVIN (Q17QG5), UB2G2_HUMAN (P60604), 
UB2G2_MOUSE (P60605), UB2G2_PONAB (Q5RF84), UB2J1_HUMAN (Q9Y385), 
UB2J1_MOUSE (Q9JJZ4), UB2J2_BOVIN (Q2TA03), UB2J2_DICDI (Q54LP7), 
UB2J2_HUMAN (Q8N2K1), UB2J2_MOUSE (Q6P073), UB2JL_DICDI (Q54AK6), 
UB2L3_BOVIN (Q3MHP1), UB2L3_HUMAN (P68036), UB2L3_MOUSE (P68037), 
UB2L3_PONAB (Q5R5I4), UB2L5_HUMAN (A0A1B0GUS4), UB2L6_BOVIN (A5PJC4), 
UB2L6_HUMAN (O14933), UB2L6_MOUSE (Q9QZU9), UB2L6_RAT   (Q4V8J2), 
UB2Q1_HUMAN (Q7Z7E8), UB2Q1_MOUSE (Q7TSS2), UB2Q2_BOVIN (Q32L27), 
UB2Q2_HUMAN (Q8WVN8), UB2Q2_MOUSE (Q8K2Z8), UB2Q2_RABIT (Q7YQJ9), 
UB2R1_HUMAN (P49427), UB2R1_MOUSE (Q8CFI2), UB2R2_HUMAN (Q712K3), 
UB2R2_MOUSE (Q6ZWZ2), UB2R2_RABIT (Q29503), UB2SA_XENLA (A1L3K1), 
UB2SB_XENLA (Q8AVU2), UB2SC_XENLA (Q76EZ2), UB2V1_BOVIN (Q3SZ52), 
UB2V1_CAEEL (O45495), UB2V1_CHICK (Q90879), UB2V1_HUMAN (Q13404), 
UB2V1_MOUSE (Q9CZY3), UB2V1_PONAB (Q5R4Z6), UB2V2_BOVIN (Q3SZ43), 
UB2V2_CHICK (Q5F3Z3), UB2V2_DANRE (Q6PEH5), UB2V2_HUMAN (Q15819), 
UB2V2_MOUSE (Q9D2M8), UB2V2_PONAB (Q5R6C9), UB2V2_RAT   (Q7M767), 
UB2V2_XENLA (Q7ZYP0), UB2V3_CAEEL (P91853), UB2WA_DANRE (Q4VBH4), 
UB2WB_DANRE (Q1JPX4), UBC10_ARATH (P35133), UBC10_DROME (Q7K738), 
UBC11_ARATH (P35134), UBC11_SCHPO (O00103), UBC11_YEAST (P52492), 
UBC12_ARATH (Q9C9Y7), UBC12_BOVIN (A3KN22), UBC12_CAEEL (Q9XVK5), 
UBC12_CANGA (Q6FVQ8), UBC12_DICDI (Q54TI6), UBC12_EREGS (Q75AF2), 
UBC12_HUMAN (P61081), UBC12_KLULA (Q6CSW8), UBC12_MOUSE (P61082), 
UBC12_SCHPO (O74549), UBC12_XENLA (Q6DCZ9), UBC12_XENTR (Q6P8D9), 
UBC12_YARLI (Q6C9W0), UBC12_YEAST (P52491), UBC13_ARATH (Q42541), 
UBC13_CAEEL (Q95XX0), UBC13_SCHPO (O13685), UBC13_YEAST (P52490), 
UBC14_ARATH (P42747), UBC14_SCHPO (Q9UTN8), UBC15_ARATH (P42743), 
UBC15_SCHPO (Q9Y818), UBC16_ARATH (Q9FWT2), UBC16_SCHPO (Q9P6I1), 
UBC17_ARATH (O23239), UBC17_CAEEL (Q11076), UBC18_ARATH (Q9FMM0), 
UBC18_CAEEL (Q21633), UBC19_ARATH (Q9LJZ5), UBC1_ARATH  (P25865), 
UBC1_CAEEL  (P52478), UBC1_COLGL  (O74196), UBC1_MIMIV  (Q5UQC9), 
UBC1_PYRO7  (Q9UVR2), UBC1_SCHPO  (O74810), UBC1_YEAST  (P21734), 
UBC20_ARATH (Q8L7T3), UBC21_CAEEL (P52484), UBC22_ARATH (Q9FF66), 
UBC23_ARATH (Q9ZVX1), UBC24_ARATH (Q8VY10), UBC25_ARATH (Q9LUQ5), 
UBC25_CAEEL (Q93571), UBC26_ARATH (Q8GY87), UBC27_ARATH (Q9FI61), 
UBC28_ARATH (Q94F47), UBC29_ARATH (Q9SLE4), UBC2M_DROME (Q9VSF3), 
UBC2_ARATH  (P42745), UBC2_ASPFU  (Q4WLA7), UBC2_CAEEL  (P35129), 
UBC2_CANAL  (O74201), UBC2_CANGA  (Q6FR76), UBC2_CRYNB  (P0CS17), 
UBC2_CRYNJ  (P0CS16), UBC2_DEBHA  (Q6BU36), UBC2_DICDI  (Q553F3), 
UBC2_EMENI  (Q96UP5), UBC2_EREGS  (Q75EB8), UBC2_FUSSL  (P78717), 
UBC2_KLULA  (Q6CUD9), UBC2_MEDSA  (P35130), UBC2_MIMIV  (Q5UQ57), 
UBC2_MYCMD  (Q4PFA5), UBC2_NEUCR  (P52493), UBC2_SCHPO  (P23566), 
UBC2_TRIHA  (Q58FS2), UBC2_WHEAT  (P25866), UBC2_YARLI  (Q6C093), 
UBC2_YEAST  (P06104), UBC30_ARATH (Q9FKT3), UBC31_ARATH (Q9C8X7), 
UBC32_ARATH (Q9LSP7), UBC33_ARATH (Q9FK29), UBC34_ARATH (Q9SHI7), 
UBC35_ARATH (Q94A97), UBC36_ARATH (Q9FZ48), UBC37_ARATH (Q941B6), 
UBC38_ARATH (Q9C918), UBC39_ARATH (F4HPP7), UBC3_ARATH  (P42746), 
UBC3_MIMIV  (Q5UQ88), UBC3_YEAST  (P14682), UBC4_ARATH  (P42748), 
UBC4_CANAX  (P43102), UBC4_MIMIV  (Q5UQ40), UBC4_SCHPO  (P46595), 
UBC4_SOLLC  (P35135), UBC4_WHEAT  (P16577), UBC4_YEAST  (P15731), 
UBC5A_ORYSJ (Q8S920), UBC5B_ORYSJ (Q8S919), UBC5_ARATH  (P42749), 
UBC5_YEAST  (P15732), UBC6_ARATH  (P42750), UBC6_CANGA  (Q6FQK7), 
UBC6_DEBHA  (Q6BYG4), UBC6_EREGS  (Q74Z34), UBC6_KLULA  (Q6CMG6), 
UBC6_SCHPO  (O42646), UBC6_YEAST  (P33296), UBC7_ARATH  (Q42540), 
UBC7_CAEEL  (P34477), UBC7_SCHPO  (O00102), UBC7_WHEAT  (P25868), 
UBC7_YEAST  (Q02159), UBC84_DROME (P52487), UBC8_ARATH  (P35131), 
UBC8_SCHPO  (Q9P7R4), UBC8_YEAST  (P28263), UBC9A_DANRE (Q9W6H5), 
UBC9B_DANRE (Q9DDJ0), UBC9_ARATH  (P35132), UBC9_CAEEL  (Q95017), 
UBC9_CHICK  (P63283), UBC9_DICDI  (Q9NGP4), UBC9_HUMAN  (P63279), 
UBC9_ICTTR  (Q2EF73), UBC9_MESAU  (O09181), UBC9_MOUSE  (P63280), 
UBC9_PAGMA  (Q6Y1Z4), UBC9_RAT(P63281), UBC9_SCHPO  (P40984), 
UBC9_XENLA  (P63282), UBC9_XENTR  (Q28CQ4), UBC9_YEAST  (P50623), 
UBCB_DICDI  (Q94490), UBCD1_DROME (P25867), UBCD2_DROME (P52485), 
UBCD4_DROME (P52486), UBCD6_DROME (P25153), UBCX_DICDI  (Q86IZ3), 
UBCX_PICAN  (O60015), UBCX_YEAST  (P29340), UBC_ASFB7   (P27949), 
UBC_ASFK5   (P0C8G3), UBC_ASFM2   (P25869), UBC_ASFP4   (P0C8G4), 
UBC_ASFWA   (P0C8G5), UBE2A_HUMAN (P49459), UBE2A_MOUSE (Q9Z255), 
UBE2B_BOVIN (Q32P99), UBE2B_HUMAN (P63146), UBE2B_MOUSE (P63147), 
UBE2B_RABIT (P63148), UBE2B_RAT   (P63149), UBE2C_BOVIN (Q32PA5), 
UBE2C_DICDI (Q54XS6), UBE2C_DROME (Q9VTY6), UBE2C_HUMAN (O00762), 
UBE2C_MACFA (Q4R9D1), UBE2C_MOUSE (Q9D1C1), UBE2C_SPISO (Q95044), 
UBE2C_XENLA (P56616), UBE2F_BOVIN (Q1RMW1), UBE2F_CHICK (Q5ZKX6), 
UBE2F_DANRE (Q6NY82), UBE2F_HUMAN (Q969M7), UBE2F_RAT   (Q5U203), 
UBE2F_XENLA (Q6IRC7), UBE2F_XENTR (Q5M8Y2), UBE2H_BOVIN (Q32LN1), 
UBE2H_HUMAN (P62256), UBE2H_MOUSE (P62257), UBE2K_BOVIN (P61085), 
UBE2K_HUMAN (P61086), UBE2K_MOUSE (P61087), UBE2N_BOVIN (Q0P5K3), 
UBE2N_DICDI (Q86K32), UBE2N_DROME (P35128), UBE2N_HUMAN (P61088), 
UBE2N_MACFA (Q4R4I1), UBE2N_MOUSE (P61089), UBE2N_PONAB (Q5R7J6), 
UBE2N_RAT   (Q9EQX9), UBE2O_HUMAN (Q9C0C9), UBE2O_MOUSE (Q6ZPJ3), 
UBE2S_AQUCT (C1C3R6), UBE2S_BOVIN (Q1RML1), UBE2S_BRAFL (C3Z724), 
UBE2S_DANRE (Q4V908), UBE2S_DICDI (Q54I43), UBE2S_DROAN (B3MQV3), 
UBE2S_DROER (B3NWW9), UBE2S_DROGR (B4JKB7), UBE2S_DROME (Q9VX25), 
UBE2S_DROMO (B4L7V4), UBE2S_DROPE (B4H9W2), UBE2S_DROPS (B5DKM4), 
UBE2S_DROSE (B4IF39), UBE2S_DROSI (B4R6G1), UBE2S_DROVI (B4MA02), 
UBE2S_DROWI (B4N208), UBE2S_DROYA (B4Q2J2), UBE2S_HUMAN (Q16763), 
UBE2S_MOUSE (Q921J4), UBE2S_NEMVE (A7SE05), UBE2S_RAT   (B5DFI8), 
UBE2S_XENTR (Q28F89), UBE2T_BOVIN (Q32LD2), UBE2T_DANRE (Q08BH7), 
UBE2T_HUMAN (Q9NPD8), UBE2T_MOUSE (Q9CQ37), UBE2T_XENLA (Q7ZY08), 
UBE2U_HUMAN (Q5VVX9), UBE2U_MACFA (Q95LM1), UBE2V_DICDI (Q54D06), 
UBE2W_BOVIN (A6H795), UBE2W_CAEEL (Q9XWF6), UBE2W_DICDI (Q55EY8), 
UBE2W_HUMAN (Q96B02), UBE2W_MOUSE (Q8VDW4), UBE2W_RAT   (B5DEI4), 
UBE2W_XENTR (Q28FC1), UBE2Z_DANRE (Q6DG60), UBE2Z_HUMAN (Q9H832), 
UBE2Z_MOUSE (Q3UE37), UBE2Z_RAT   (Q3B7D1), UBE2Z_XENLA (Q6PCF7), 
UBE2Z_XENTR (Q66KB0), UE2NL_HUMAN (Q5JXB2), UEV1A_ARATH (Q93YP0), 
UEV1B_ARATH (Q9CAB6), UEV1C_ARATH (Q9SJ44), UEV1D_ARATH (Q9SVD7), 
Y1A1_ENCCU  (Q8SSK3)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

411 PDB

1A3S; 1AYZ; 1C4Z; 1FBV; 1FXT; 1FZY; 1I7K; 1J74; 1J7D; 1JAS; 1JAT; 1JBB;
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