PROSITE entry PS50104

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50104
Entry name [info]	TIR
Accession [info]	PS50104
Entry type [info]	MATRIX
Date [info]	01-JAN-2002 CREATED; 07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50104
Associated ProRule [info]	PRU00204

Name and characterization of the entry

Description [info]

TIR domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=142;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=137;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9004707; R2=0.0080595; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=21907.6386719; R2=3.2387173; PRIORITY=1; TEXT='Heuristic 0.1%';
/CUT_OFF: LEVEL=0; SCORE=1005; H_SCORE=25163; N_SCORE=10.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=571; H_SCORE=23757; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-24; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='K';  M= -45,  -2, -21,  14,   8, -50, -61, -30,  53, -13, -60,  -3,  -7, -14,  33, -20,   4, -17,  49,   0;
/M: SY='E';  M= -32,  20,   5,  37,   6,  -1, -49, -41,   7,   4,  14, -26, -25,  23,  14,  -7,  25, -36, -76, -61;
/M: SY='Y';  M= -69,   3, -18, -28,  42, -75,  25, -25,   1, -36, -54, -18,  11, -60,  -6, -44, -63, -45,  -8, 103;
/M: SY='D';  M= -39, -79,  99,  22, -85, -60,  14, -83, -12, -81, -76,  13, -49,  26, -48,  -9, -43, -79, -94, -68;
/M: SY='V';  M=  59, -23, -73, -28,  -2, -67, -76,  15, -68, -49, -50, -69, -72, -35, -71, -54,  -4,  66, -78, -62;
/M: SY='F';  M= -71, -10, -82, -80, 100, -82, -61,   0, -75,   1, -47, -45, -84, -79, -73, -72, -64,   1, -43,  66;
/M: SY='I';  M= -53, -72, -83, -77,   7, -85, -79,  71, -35,  27, -13, -77,   0, -74, -76, -70, -40,  53, -74, -55;
/M: SY='S';  M= -41,  57, -64, -65, -32, -63, -65,  21, -28,   7, -54,  21, -72, -59, -45,  72, -46,  16, -80, -31;
/M: SY='Y';  M= -72, -18, -72, -73,  74, -79,  74,  -7, -68, -50, -50, -67, -81, -66, -65, -67, -66, -59, -40, 102;
/M: SY='S';  M=  16,  43,  -1,  -9, -75, -26,   2, -72,  -7, -55, -66, -34,  11, -51,  48,  59, -22, -33, -82, -67;
/M: SY='G';  M= -12,  27, -20,  25, -75,  41,  28, -35,  23, -59, -66, -38,  -1, -16,  33,  18, -23, -71, -77, -20;
/M: SY='K';  M=  13, -29,  23,  24, -54, -65,  24, -44,  34, -40, -62,  14, -18,  33, -23,   2,  -3,   5,  19, -32;
/M: SY='D';  M=   0, -23,  94,  22, -47, -64,   9, -52, -55, -66, -72,   3,   4, -11, -62, -20, -20, -39, -90, -27;
/I:         I=-19; MI=0; MD=-49; IM=0; DM=-49;
/M: SY='W';  M= -48, -92, -16,  12, -56, -62, -91,  -5, -82, -16, -70, -85, -90, -80, -59, -25,  -3,  35,  65, -51; D=-19;
/I:         I=-19; DM=-49;
/M: SY='R';  M= -10,  34,   1,  25, -80, -23, -66, -75, -29, -36, -70, -39, -76,   7,  60,  10, -26, -11, -87, -73; D=-19;
/I:         I=-19; DM=-49;
/M: SY='D';  M= -23, -78,  46,  40, -31, -53,  27, -23,  11, -11, -63,  27, -69,  11,  12, -15, -33, -56, -77,  16; D=-19;
/I:         I=-19; DM=-49;
/M: SY='W';  M= -14, -78, -13,   8,  -9,  -4,  40, -44, -31, -62, -64,  -1, -70,  31, -24,  13,  25, -55, 104,  32; D=-19;
/I:         I=-19; DM=-49;
/M: SY='F';  M= -33, -71, -41, -77,  87, -62, -72,  -6, -39,  32, -44, -76, -82, -40, -74, -71, -62,  41, -58, -37; D=-19;
/I:         I=-19; DM=-49;
/M: SY='V';  M=  25, -22, -43,  -2, -58, -74, -70,  17, -22,  12, -28, -49, -73,   1,  -5, -59,   8,  49,  24,  -5; D=-19;
/I:         I=-19; DM=-49;
/M: SY='S';  M= -22, -70,  -6,  21, -27, -35,  18, -64, -13,  12, -59,  50, -68,  22, -40,  57, -28, -33, -80, -42;
/M: SY='H';  M= -49, -78,  -9,  51,  17, -75,  94, -28,   2,  17, -53, -28, -69, -16,  -4, -49, -63, -46,  18, -22;
/M: SY='L';  M= -66, -71, -82, -76,  45, -58, -69,  30, -73,  65,  42, -76, -80, -36, -28, -57, -18,  -6, -66, -47;
/M: SY='L';  M= -12, -71, -22,  -4, -23, -53, -64,   6,  -9,  36,  13, -66, -74, -23,  25,   9, -56,  36, -72,  11;
/M: SY='P';  M=  -3, -77, -16,  14, -17, -48, -22, -67,  36, -54, -64, -28,  71,  20,   5,  15, -28,  -9, -75, -16;
/M: SY='Q';  M=  21, -16,  15,  35, -71, -36,  26, -43,   9, -56,  18,  16, -32,  44,   2,  -6, -36,  -3, -78,  -7;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='L';  M= -66, -69, -82, -30,   5, -85, -68, -22, -76,  82,  16, -81, -82, -70, -74, -75, -62,   9, -69, -14;
/M: SY='E';  M= -47, -31,  -3,  84, -79, -31, -21, -44,   3, -51, -67, -26, -62,  33,  36, -11, -44, -44, -79, -68;
/M: SY='R';  M= -12, -75,  -9,  19, -30,  -7,  -1, -73,  28, -17, -37,  33, -68,  29,  56,   8, -22, -70, -77, -33;
/M: SY='Q';  M= -13, -52,  10,  37, -23, -12,  33, -74,  36, -27, -63,  18, -35,  38,  27, -16,  -2, -71, -77, -29;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='G';  M= -20, -75,  -1, -52, -62,  79,  -2, -81, -10, -54, -70,  23,  19, -41, -29,  -1, -14, -77, -78, -72;
/M: SY='Y';  M= -66, -76, -80, -78,  41, -84, -64,  71, -71,   8, -33, -47, -79, -71, -18, -56, -61,  13, -54,  72;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='K';  M= -53, -88, -52, -62, -86, -20, -15, -56,  51, -51, -75,  30, -81,  15,  43, -10, -32, -83, -88, -35; D=-25;
/I:         I=-25; DM=-63;
/M: SY='L';  M= -16,   5, -62, -50,   2, -62, -78,  -9, -77,  49, -29, -33, -23, -76, -53, -35,   4,  33, -82, -63; D=-25;
/I:         I=-25; DM=-63;
/M: SY='C';  M= -58, 108, -58, -81,  70, -39, -77, -67, -52, -48, -20, -32, -48, -83, -80, -36,  20, -50, -10, -33; D=-25;
/I:         I=-25; DM=-63;
/M: SY='I';  M= -39, -76, -86, -81,  47, -86, -77,  54, -62,  42, -29, -36, -83, -57, -60, -23, -46,   4,  -4, -33; D=-25;
/I:         I=-25; DM=-63;
/M: SY='H';  M= -53,  27,  56,  23,  19, -62,  60,  -8, -49, -24, -45, -25,  11,   4, -28, -40, -53, -33, -79,  12; D=-25;
/I:         I=-25; DM=-63;
/M: SY='D';  M= -37, -79,  63,  57,  -5, -10, -21, -71, -17, -48, -69, -14, -68, -26, -40, -14, -22,  -1, -81,   6; D=-25;
/I:         I=-25; DM=-63;
/M: SY='R';  M= -29,  -5,  21,  17, -72, -61,  15, -51,  -8, -44, -31,  -2, -74, -18,  82, -53, -48, -25,  -7,   1; D=-25;
/I:         I=-25; DM=-63;
/M: SY='D';  M= -45, -78,  84,  35,   4, -16, -36, -60,   6, -24, -69,  -5, -38, -26,  13, -42, -25, -59, -83, -48;
/M: SY='W';  M= -35, -73, -15,   7,  47, -79, -68,  16, -53,  40,  29, -71, -27,  10, -54, -26, -61,  19,  54, -48;
/M: SY='E';  M= -22, -74,   0,  29, -20, -27, -62,  10,  -5,  17,   5, -14,   0,  -9,   9, -35, -21,  24, -72,  19;
/M: SY='P';  M=   4,  -1, -65, -41, -77,  15, -24, -27, -45, -75, -66, -17,  96, -61,  30, -15, -59, -27, -78, -28;
/M: SY='G';  M= -52, -75,  18, -15, -28,  82, -65, -81, -23, -38, -70, -12, -67, -27, -30,  13,  -6, -76, -76, -71;
/M: SY='K';  M=  -3, -18,   3,  33, -48,  22,   9, -56,  34, -35, -63,  -2, -31,  29,  22, -21, -13, -10, -78, -43;
/I:         I=-42; MD=-106;
/M: SY='D';  M=   6,  22,  28, -23, -32, -18, -38, -34, -54, -21, -68,   0,   1, -27,  -7,  24,  23, -46,  24, -12; D=-42;
/I:         I=-42; MI=-106; MD=-106; IM=-106; DM=-106;
/M: SY='I';  M= -52, -81, -80,   1,  36, -49,   8,  58, -62,   1, -30, -77, -38, -73, -35, -74, -42,  17,  33,  11; D=-42;
/I:         I=-42; DM=-106;
/M: SY='W';  M=  10, -72, -11, -21,   9, -15,  -3,  22, -46,  28,  -4, -64, -28, -62,  -9,  24, -13,   4,  51, -55;
/M: SY='E';  M=   5, -75,  35,  55, -28, -56,   5, -41, -11, -56, -67,  -3,  23,   7, -12,  28,   1, -43, -80, -32;
/M: SY='N';  M=  -2,  23,  14,  43, -72, -42, -55, -14,  -3, -59, -64,  68, -68,   4,  -5,  -2, -33,  -2, -82,  -9;
/M: SY='L';  M= -39, -71, -23, -33, -49, -80,   7,  53, -72,  61, -15, -70, -76, -37, -73, -15,  11,  -4, -76, -56;
/M: SY='Q';  M= -44,  -2,  13,  -9,  21, -47, -22,  24, -18,  30,  -1,  -6, -73,  34, -51,  -3,   1,   4,  22, -54;
/M: SY='D';  M=  -2, -74,  45,  41, -78, -64, -19, -74,  27, -57, -67,  20, -65,  40,   6,  26,  -6, -39,   2, -66;
/M: SY='A';  M=  50,  19, -61,  -1, -18, -38,  -1, -40, -26,  -2,   7,  16, -29, -54,  19,  36, -41, -32, -77, -48;
/M: SY='I';  M= -49, -74, -84, -81,  -2, -45, -80,  87, -77,  21,  10, -76, -76, -74, -79, -71, -37,  33, -73, -55;
/M: SY='E';  M= -36, -77,  17,  54, -13, -31, -32, -61,  22, -35, -29,  33, -40,  29,  31,  -5, -25, -53,  13, -12;
/M: SY='H';  M= -44, -76,  12,  34, -28,  -6,  48, -73,  47, -27, -37,  22, -66,  16,  24,   3, -29, -42, -78, -32;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='S';  M=  16,  61, -36, -59, -71, -37, -61, -73, -59, -74, -68, -49, -67, -53, -26,  92, -26, -64, -80,  -4;
/M: SY='R';  M=   4, -79, -24, -30, -73, -31,  16, -79,  53, -74, -64, -53, -70, -33,  89, -47, -43, -73, -74,  -5;
/M: SY='R';  M= -48,  45, -69, -62,  19, -76, -35,  35,  43, -47, -31, -11, -74, -34,  49, -31, -42,  28,  22, -26;
/M: SY='T';  M=  27, -67, -68, -65,   2, -17, -32,  14,  -5,  11,  23, -60, -69, -33, -32,  27,  40,  10, -75, -40;
/M: SY='I';  M= -46, -71, -84, -80, -27, -86, -80,  73, -77,  32,  -3, -78, -78, -75, -78, -71, -57,  60, -77, -57;
/M: SY='V';  M=  -2,  31, -82, -77,  49, -80, -74,  27, -75,  29,  22, -76, -55, -75, -75, -52, -57,  56, -69, -22;
/M: SY='V';  M= -59, -70, -84, -79, -38, -86, -80,  58, -76,  34,  15, -79, -78, -75, -77, -71, -56,  72, -79, -57;
/M: SY='L';  M= -66, -70, -84, -78,  53, -85, -71,  30, -77,  65,  23, -79, -81, -74, -75, -73, -26,  19, -65, -45;
/M: SY='S';  M= -13,  -1, -44, -58, -72, -54, -62, -67, -58, -72, -67, -47, -13, -53, -63,  91,  54, -28, -84, -67;
/M: SY='P';  M=   0, -78,  25,  36, -80,  -7,  13, -77,  17, -77, -68,  -2,  59,  13,  21,  10, -29, -60, -81, -69;
/M: SY='N';  M= -41, -72,  38,  14, -78,  -5,  45, -78,  -5, -79, -69,  81, -67,  -6, -17,  24,   6, -75, -89, -66;
/M: SY='Y';  M= -17, -14, -25, -47,  67, -74, -52, -40, -21,   3,  -2, -26, -79, -65, -41,  -7, -36, -42, -44,  93;
/M: SY='L';  M=  25,  24,   4, -45, -56, -43, -69,   8, -35,  41,  -7, -65, -41, -55, -30, -13,   9,  30, -78, -29;
/M: SY='Q';  M= -15,  37,  27,   7, -45, -22,  16, -68,  20, -22, -62,   4, -17,  41,  16,  32, -36, -15, -80, -36;
/M: SY='S';  M= -51, -15,  32, -24,  17, -39, -19, -73, -25, -73, -68,  11, -67, -23,  19,  81, -11, -68, -78, -32;
/I:         I=-13; MI=0; MD=-33; IM=0; DM=-33;
/M: SY='E';  M= -47, -36,  12,  31, -79,   7, -21, -76,  30, -41, -71, -59,  28, -56,   0,   9,   9, -21,   9, -41; D=-13;
/I:         I=-13; DM=-33;
/M: SY='W';  M= -48, -89, -30,  -6, -40, -18, -78, -68,  -8,   0, -66, -34,  -6,  -2, -37, -27, -73, -47, 146,   4; D=-13;
/I:         I=-13; DM=-33;
/M: SY='C';  M= -14, 127, -78, -77,  16, -73, -77, -33, -74, -39, -65, -26, -85, -76, -59,  27, -58,  -8,   5, -68; D=-13;
/I:         I=-13; DM=-33;
/M: SY='L';  M= -39, -76,  -6, -61, -58, -76,  37,  -2,  15,  51,  -1,   0, -44,  20,  24, -21, -62, -36, -77, -29; D=-13;
/I:         I=-13; DM=-33;
/M: SY='F';  M= -39, -24,  45,   8,  50, -72,  25, -54,  -2, -13, -20,  22, -74, -17,  10, -20, -28, -67, -65,  43; D=-13;
/I:         I=-13; DM=-33;
/M: SY='E';  M= -19, -80,   0,  87, -12, -73, -22, -51, -17, -29, -67, -57, -33,  49, -53,  -7, -60, -72, -78, -67; D=-13;
/I:         I=-13; DM=-33;
/M: SY='L';  M= -67, -73, -75,   0,  44, -83, -66,  -2, -29,  61,  10, -74, -54,   0, -69, -70,   0, -16, -65,  15; D=-13;
/I:         I=-13; DM=-33;
/M: SY='V';  M=  -8, -75,  -1,  14, -61, -39, -61, -13,  27,   1, -10,  13, -73,  11,   6, -44, -58,  39, -74,  28; D=-13;
/I:         I=-13; DM=-33;
/M: SY='F';  M=   2, -36, -62,  28,  32, -73,  14,  23,  27,  -7,   1, -61, -70,  25, -36,  -6,   6, -14, -71, -15; D=-13;
/I:         I=-13; DM=-33;
/M: SY='A';  M=  57, -69, -72, -67, -64,  -4,  -8,  47, -64, -16,  18, -64, -71, -62,   1,  15, -34,  -7, -77, -64; D=-13;
/I:         I=-13; MI=0; MD=-33; IM=0; DM=-33;
/M: SY='H';  M= -60, -97, -82, -48, -23, -65,  52, -80, -79,  10, -10,  15, -96,  28, -28, -19, -82, -68, -95,   1; D=-13;
/I:         I=-13; DM=-33;
/M: SY='M';  M= -66,  -3,  -7,   3, -76, -73,   2, -49,   0,  -8,  40,  38, -35,  13,   7,  28, -17, -59,  -4, -70; D=-13;
/I:         I=-13; DM=-33;
/M: SY='E';  M=  15,   9, -10,  33, -69, -78, -70, -60,  -2,  25,  26, -54, -77, -22,  -1, -39, -23, -10,  15, -69; D=-13;
/I:         I=-13; DM=-33;
/M: SY='C';  M= -28,  70, -78, -74,  23, -21,  -1, -14, -56,  38, -54, -17, -84,  18, -20, -16,  -8, -59, -79, -40; D=-13;
/I:         I=-13; DM=-33;
/M: SY='R';  M= -53, -83, -14,   5, -22, -79,  21,  -8,  12, -34,  12, -47,   7,  25,  35, -19, -27,   8,  26,  -2; D=-13;
/I:         I=-13; DM=-33;
/M: SY='Q';  M= -39, -80,  31,  48, -55, -11,  10, -77,  16, -19, -67,  20, -41,  50,  -6,  -6, -31, -57, -84, -68; D=-13;
/I:         I=-13; DM=-33;
/M: SY='N';  M=   9, -40,   3,  26, -74,  17,  37, -73,   7, -20, -40,  51, -43,  11,  15,   9, -25, -62, -81, -49;
/M: SY='N';  M= -58,  21, -30,   2,  -8,  26, -11, -49,  28,  -6, -28,  33, -16, -33,  16,  24,  -3, -56,  20, -18;
/M: SY='D';  M= -42, -76,  50, -10, -72,  21,   8,   3,   7, -45,   3,  -7,  19,  19,   8,  15,  -6, -45, -79, -13;
/M: SY='K';  M=   2, -31,  11, -36, -71, -37,  13, -53,  50,   9, -57,   8,   7,  45,  13,  -9, -35, -23, -78, -43;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='V';  M= -10,  36, -70, -31,  -8, -55, -69,  36, -35,   7,   6,  23, -36, -64,  12, -18, -13,  49, -79, -60;
/M: SY='V';  M= -17, -70, -83, -78, -34, -84, -83,  71, -75,  -4, -39, -76, -76, -75, -78, -67, -20,  73, -80, -59;
/M: SY='I';  M= -63, -72, -85, -80,   9, -86, -76,  69, -77,  44,  36, -78, -78, -73, -77, -73, -59,  42, -72, -30;
/M: SY='P';  M= -64, -81, -72, -64, -15, -75, -73,  48, -44, -17, -53, -71,  98, -68, -25, -45,   5,   6, -77, -67;
/M: SY='I';  M= -61, -73, -71,  26,  18, -55, -73,  62, -43,  27,   3, -73, -74, -31, -71, -68, -34,  44, -73, -55;
/M: SY='F';  M= -69,   6, -81, -48,  84, -83, -66, -10, -18,  50,  -3, -75, -82, -72,  -6, -72, -48, -24, -55,  12;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='Y';  M= -58,  44, -31,  50, -10,  -7, -45, -64, -23,  -7, -57, -63,   3,   3, -28, -27, -39, -53, -53,  88;
/M: SY='K';  M= -33, -77,   6,  23, -40,  36, -17, -75,  45, -29, -40,   5,  39, -23,   1, -20,  -1, -73,  18, -67;
/I:         I=-8; MD=-20;
/M: SY='V';  M= -22,  -4, -24, -74,  -6, -81, -77,  40, -50,  15,   4, -22, -24, -34, -64, -23, -47,  63, -81, -61; D=-8;
/I:         I=-8; MD=-20;
/M: SY='D';  M= -39, -25,  48,  25, -83, -57,  -1, -62,   1, -44, -26,  -2,  20,  22,  13,  32, -20, -76, -88, -72; D=-8;
/I:         I=-8; MD=-20;
/M: SY='P';  M= -43, -90,  29, -28, -40, -75, -70, -82,   4, -31, -76,  -3,  73,  25, -27,  11, -65, -83, -16, -78; D=-8;
/I:         I=-8; MD=-20;
/M: SY='Y';  M= -12, -26, -54, -22, -29, -74, -10, -60, -27, -14, -52, -36, -49, -49, -39,  53, -16, -60,  -5,  53; D=-8;
/I:         I=-8; MD=-20;
/M: SY='D';  M= -17, -30,  47,   8, -94, -81,  25, -63, -12, -53, -82, -19, -22,  28, -71,  -3,   0, -86,-102, -81; D=-8;
/I:         I=-8; MD=-20;
/M: SY='V';  M= -83, -40,-104, -98, -27,-107, -99,  17, -45,  19, -31, -99,-102, -94, -34, -92, -50,  42,-100, -79; D=-8;
/I:         I=-8; MD=-20;
/M: SY='R';  M= -87, -34, -41,  -3,-100, -95, -84, -94,  -7, -63,  25, -22,  30, -74,  34,  -9, -83, -67,-105, -93; D=-8;
/I:         I=-8; MI=0; MD=-20; IM=0; DM=-20;
/M: SY='R';  M= -34, -96, -76,  -5, -95, -26, -76, -11,  19, -89, -81, -20, -40,  36,  38,  -4, -76, -72, -95, -84; D=-8;
/I:         I=-8; DM=-20;
/M: SY='W';  M= -88,-100, -55, -54,  39, -94, -14, -75, -83, -19,  15, -93, -96, -13, -32, -89, -89, -65, 117,  39; D=-8;
/I:         I=-8; DM=-20;
/M: SY='C';  M= -16,  34, -76, -17, -50, -83,  23, -11,  25, -27,   6, -71,   6, -13,  29, -19, -70,  -6, -90, -73; D=-8;
/I:         I=-8; DM=-20;
/M: SY='E';  M= -13, -84,   4,  40, -83, -59, -13, -67,  28, -38, -72, -20, -73,  22,  38, -22,   5, -61, -87, -48; D=-8;
/I:         I=-8; DM=-20;
/M: SY='A';  M=  51, -76, -14, -14, -40, -69, -68, -33, -11,  22, -27, -68,  18,  34, -23, -35, -62, -46, -79, -34; D=-8;
/I:         I=-8; DM=-20;
/M: SY='L';  M= -47, -76, -80, -71,  32, -84, -67, -25,   6,  47,  19, -74, -82, -66,  36, -72, -28,   9,   7,  13; D=-8;
/I:         I=-8; DM=-20;
/M: SY='H';  M=   4, -77,  -6,   4, -74,  16,  38, -75,  28, -45, -43, -17,  22,  24,   2, -24,  27, -71, -14,  -4; D=-8;
/I:         I=-8; DM=-20;
/M: SY='S';  M= -34, -42,  23,  -1,   2, -13, -20, -22,   9,  -7,  -1,   6,  -5, -10,  24,  26, -34, -51, -24,  17; D=-8;
/I:         I=-8; DM=-20;
/M: SY='I';  M=  15, -71, -77, -21,  18, -78, -73,  42, -48,  35,  24, -48, -50, -69, -73, -40,   2,  31, -74, -56; D=-8;
/I:         I=-8; DM=-20;
/M: SY='C';  M=  18,  25, -27, -31,  13, -16, -66,   0,  18,  24, -54,   2,   7, -12, -30,   4, -10, -41, -74, -33; D=-8;
/I:         I=-8; DM=-20;
/M: SY='R';  M= -45,  -9,  27, -50, -33, -28,  -8, -76,  38, -63, -39,  43, -25,  21,  55,  10,  16, -63, -81, -65; D=-8;
/I:         I=-8; DM=-20;
/M: SY='W';  M= -63, -76, -69, -20,  31, -56,  16,  35,   4,  18,  -5,   1, -10,  15, -20,  12, -38, -15,  72, -50; D=-8;
/I:         I=-8; DM=-20;
/M: SY='S';  M=  16,   3, -18, -59, -65, -47,   4,   1,  -9,  15,   8,  14,  -1,  22, -15,  32,  25, -45, -79, -31; D=-8;
/I:         I=-8; DM=-20;
/M: SY='G';  M= -32, -30, -65, -49, -44,  58, -21, -17, -14, -63,  -8,  -8, -35,   8,   8, -54,   8,  20, -65,  56;
/I:         I=-18; MD=-45;
/M: SY='H';  M= -67, -41, -22, -11, -24, -46,   6,  -1, -23, -36, -47, -88,-100, -13, -90, -19, -49, -23, -31,  -3; D=-18;
/I:         I=-18; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='W';  M= -68, -77,   7, -69, -45, -79,  43,   7, -35,  60, -43, -72, -79, -66, -70, -25, -66, -31, 111,   8;
/I:         I=-10; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='C';  M= -39,  41, -31,  24,  -4, -77,  17, -80,  14, -24, -70,  32, -61,  19,  14, -22, -18, -78,  13, -24; D=-10;
/I:         I=-10; DM=-25;
/M: SY='W';  M= -18, -91,  30, -19, -46,   3, -78, -58,   9, -79, -77, -39, -80, -49, -26, -70, -26, -31, 126,   9; D=-10;
/I:         I=-10; DM=-25;
/M: SY='P';  M= -30,   3,  31,  29, -78, -40, -65, -60, -24, -27,   8, -52,  66, -18,  18, -22, -65, -76, -83,   1; D=-10;
/I:         I=-10; DM=-25;
/M: SY='D';  M= -53, -79,  27,   5, -70, -27,  14,  -8,  23, -40, -40,  19, -31,  -7, -23,  18,  13, -11, -81,  19; D=-10;
/I:         I=-10; DM=-25;
/M: SY='D';  M= -22, -36,  53,  44, -84, -49, -60, -25, -18, -78, -72,  13,  22,  40, -42,  28, -58, -52, -88, -73; D=-10;
/I:         I=-10; DM=-25;
/M: SY='P';  M=   7, -73,   0,  12,  -8, -39, -61, -66,  11, -36,  -8,  12,  40,  15,   3,  28,  18, -15, -79, -66; D=-10;
/I:         I=-10; DM=-25;
/M: SY='W';  M=  -8,  31,  25,  41, -56, -53,   4, -24,   9, -27, -64, -24, -47,   7,   6,  23,  14, -57,  56,  -9;
/M: SY='M';  M=   6,   4, -10, -59,   9,   4, -51, -35,   1,  21,  43, -60,   2,  33,  22, -39,  10, -48, -70,  10;
/M: SY='I';  M= -46,  -5,   8, -14, -37, -60,  -5,  41,  26,   1, -14,   4, -47,  41,   3, -21, -57,  28, -78, -60;
/M: SY='E';  M= -11, -75,  20,  51, -78,  16,  -5, -45,   7, -49, -67,  19,  17,  21, -17,  21,  -5, -46, -81, -69;
/M: SY='W';  M=   1, -77,  -4,  37, -68, -18, -21, -23,  49, -20, -28, -44, -66,  36,  17, -11, -37, -53,  65,  -3;
/M: SY='F';  M= -66, -73,  -8, -49,  85, -26, -72,  55, -47, -24,  13, -71, -78, -76, -75, -69, -27,  23, -11, -38;
/M: SY='W';  M=  17, -79, -79, -49, -22, -70, -14, -16,  -7, -31, -60, -73, -74, -17, -27, -14, -10,  21, 141,   3;
/M: SY='K';  M=  -2, -76,  13,  -4, -47, -70,  13,  -6,  61, -45, -61,  -3, -68,   6,  58, -56,  -6, -36, -76, -34;
/M: SY='D';  M=  15, -21,  45,   9,  -9, -63,   5, -74,  31, -44, -66,  42, -68,  25,  22,   8, -21, -70, -16, -63;
/M: SY='L';  M= -36, -69, -82, -76, -46, -84, -74,  41, -75,  60, -19, -78, -79, -72, -76, -69,  -4,  52, -75, -16;
/M: SY='R';  M=  -6, -75, -24, -33,  -8, -37, -57, -23,  29, -22, -59, -54, -70,  30,  68,  34, -19, -42, -71,   3;
/M: SY='Y';  M=  -2, -74, -12,  42, -34,  -5, -55, -57,  30, -18, -30,  28, -67,   8,   1, -19,   0, -20, -68,  47;
/M: SY='A';  M=  49, -11,   9,  -4, -72, -64,  17, -23,  28, -41,  25, -56, -41,  42,  -7, -21, -15,   6, -79, -64;
/M: SY='M';  M= -45, -70, -77, -71,   2, -56, -15,  28, -31,  57,  64, -70, -40, -44, -69,  22, -48,  -1, -72, -53;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.

Total number of hits	208 in 206 different sequences
Number of true positive hits	208 in 206 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	6
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	97.20 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	TIR
Version [info]	7

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

206 sequences

ABTIR_ACIB9 (A0A009IHW8), ADR2_ARATH  (Q9C7X0), APTIR_ACTS5 (G8SD34),

BANK1_HUMAN (Q8NDB2), BANK1_MOUSE (Q80VH0), BCAP_CHICK  (Q9DDT2), 
BCAP_HUMAN  (Q6ZUJ8), BCAP_MOUSE  (Q9EQ32), BDTIR_BRADI (I1GTC2), 
BTTIR_BACT4 (A0A0P0FGV9), CHL1_ARATH  (Q9LUJ8), CHS1_ARATH  (F4I902), 
CSA1_ARATH  (F4KIF3), DAR4_ARATH  (Q9FKN7), DSC1_ARATH  (Q9SZ66), 
DSC2_ARATH  (F4JWM0), I18RA_HUMAN (O95256), I18RA_MOUSE (Q9Z2B1), 
IL18R_HUMAN (Q13478), IL18R_MOUSE (Q61098), IL1AP_HUMAN (Q9NPH3), 
IL1AP_MACMU (P59822), IL1AP_MOUSE (Q61730), IL1AP_RAT   (Q63621), 
IL1R1_HUMAN (P14778), IL1R1_MOUSE (P13504), IL1R1_RAT   (Q02955), 
ILRL1_HUMAN (Q01638), ILRL1_MOUSE (P14719), ILRL1_RAT   (Q62611), 
ILRL2_HUMAN (Q9HB29), ILRL2_MOUSE (Q9ERS7), ILRL2_RAT   (Q62929), 
IRL1A_DANRE (B6ZK76), IRL1B_DANRE (B6ZK77), IRPL1_HUMAN (Q9NZN1), 
IRPL1_MOUSE (P59823), IRPL1_PANTR (P60029), IRPL1_PONPY (Q7YQL9), 
IRPL1_RAT   (P59824), IRPL2_HUMAN (Q9NP60), IRPL2_MOUSE (Q9ERS6), 
L6_LINUS(Q40253), LAZ5_ARATH  (O48573), MY88A_XENLA (Q9DF60), 
MY88B_XENLA (Q5FWM2), MYD88_BOVIN (Q599T9), MYD88_CERAT (B6CJX2), 
MYD88_CHICK (A5HNF6), MYD88_DANRE (Q5XJ85), MYD88_GORGO (B3Y680), 
MYD88_HUMAN (Q99836), MYD88_MACFA (B3Y682), MYD88_MACMU (B3Y683), 
MYD88_MOUSE (P22366), MYD88_ONCMY (Q4LBC6), MYD88_PANPA (B3Y679), 
MYD88_PANTR (B3Y678), MYD88_PIG   (A2TF48), MYD88_PONPY (B3Y681), 
MYD88_RAT   (Q6Y1S1), MYD88_SALSA (B3SRQ2), MYD88_SHEEP (C8BKC7), 
MYD88_TAKRU (A8QMS7), MYD88_XENTR (Q28DJ2), P2A05_ARATH (Q9C5Q9), 
P2A06_ARATH (Q9FHE8), P2A07_ARATH (Q9FHE5), P2A08_ARATH (Q9FHE9), 
PDTIR_PARDP (A1AY86), RBA1_ARATH  (F4HT77), RLM1A_ARATH (F4I594), 
RLM1B_ARATH (Q9CAK1), RLM3_ARATH  (Q9FT77), ROQ1_NICBE  (A0A290U7C4), 
RPP1_ARATH  (F4J339), RPP2A_ARATH (F4JT78), RPP2B_ARATH (F4JT80), 
RPP2C_ARATH (F4JT82), RPP2D_ARATH (O49471), RPP4_ARATH  (F4JNA9), 
RPP5_ARATH  (F4JNB7), RPS4B_ARATH (Q9FHF0), RPS4L_ARATH (Q9SCX6), 
RPS4R_ARATH (Q9SCX7), RPS4W_ARATH (C4B7M7), RPS4_ARATH  (Q9XGM3), 
RPS6C_ARATH (F4KHH8), RPS6R_ARATH (P0DKH6), RPV1_VITRO  (V9M2S5), 
RRS1B_ARATH (Q9FL92), RUN1_VITRO  (V9M398), SARM1_CAEEL (Q86DA5), 
SARM1_DANRE (F1QWA8), SARM1_DROME (Q6IDD9), SARM1_HUMAN (Q6SZW1), 
SARM1_MOUSE (Q6PDS3), SARM1_PIG   (I3L5V6), SARM1_RAT   (D3ZUM2), 
SIGIR_HUMAN (Q6IA17), SIGIR_MOUSE (Q9JLZ8), SIGIR_RAT   (Q4V892), 
SNC1_ARATH  (O23530), STING_MAGGI (P0DUE1), TAO1_ARATH  (Q9FI14), 
TCAM1_BOVIN (Q4JF29), TCAM1_HUMAN (Q8IUC6), TCAM1_MOUSE (Q80UF7), 
TCAM2_BOVIN (Q2LGB7), TCAM2_HUMAN (Q86XR7), TCAM2_MOUSE (Q8BJQ4), 
TCPA_THEAD  (A0A151EH88), TCPB_BRUA2  (Q2YPC4), TCPB_BRUMB  (C0RGW8), 
TCPB_BRUME  (Q8YF53), TCPC_ECOL6  (A0A0H2V8B5), TCPF_ENTFA  (Q833J1), 
TCPO_METOL  (A0A1I4KS07), THSB2_CYTDA (A0A5B8Z260), TIK_ARATH   (Q0WSX8), 
TIRAP_HUMAN (P58753), TIRAP_MOUSE (Q99JY1), TIRA_DICDI  (Q54HT1), 
TIRC_DICDI  (Q54F65), TIRS_STAAS  (P0DTS9), TIR_ARATH   (Q9SSN3), 
TLR10_BOVIN (Q6GV17), TLR10_HUMAN (Q9BXR5), TLR11_MOUSE (Q6R5P0), 
TLR12_MOUSE (Q6QNU9), TLR13_MOUSE (Q6R5N8), TLR1_HUMAN  (Q15399), 
TLR1_MOUSE  (Q9EPQ1), TLR21_CHICK (Q9DD78), TLR22_CHICK (Q9DGB6), 
TLR2_BISBI  (B2LT61), TLR2_BOSIN  (B5T267), TLR2_BOSTR  (Q2V897), 
TLR2_BOVIN  (Q95LA9), TLR2_BUBBU  (Q2PZH4), TLR2_CANLF  (Q689D1), 
TLR2_CAPHI  (Q0GC71), TLR2_CAPIB  (B2LT62), TLR2_CRIGR  (Q9R1F8), 
TLR2_GIRCA  (B2LT64), TLR2_GORGO  (B3Y615), TLR2_HORSE  (Q6T752), 
TLR2_HUMAN  (O60603), TLR2_MACFA  (Q95M53), TLR2_MACMU  (B3Y618), 
TLR2_MOUSE  (Q9QUN7), TLR2_PANPA  (B3Y614), TLR2_PANTR  (B3Y613), 
TLR2_SHEEP  (B2LT65), TLR3_BOSTR  (Q0PV50), TLR3_BOVIN  (Q5TJ59), 
TLR3_HUMAN  (O15455), TLR3_MOUSE  (Q99MB1), TLR4_BOSTR  (Q2V898), 
TLR4_BOVIN  (Q9GL65), TLR4_CRIGR  (Q9WV82), TLR4_FELCA  (P58727), 
TLR4_GORGO  (Q8SPE8), TLR4_HORSE  (Q9MYW3), TLR4_HUMAN  (O00206), 
TLR4_MOUSE  (Q9QUK6), TLR4_PANPA  (Q9TTN0), TLR4_PAPAN  (Q9TSP2), 
TLR4_PIG(Q68Y56), TLR4_PINIB  (V5NAL9), TLR4_PONPY  (Q8SPE9), 
TLR4_RAT(Q9QX05), TLR5_HUMAN  (O60602), TLR5_MOUSE  (Q9JLF7), 
TLR6_BOVIN  (Q704V6), TLR6_DASNO  (Q0ZUL9), TLR6_HUMAN  (Q9Y2C9), 
TLR6_MOUSE  (Q9EPW9), TLR7_HUMAN  (Q9NYK1), TLR7_MOUSE  (P58681), 
TLR8_HUMAN  (Q9NR97), TLR8_MOUSE  (P58682), TLR9_BOVIN  (Q5I2M5), 
TLR9_CANLF  (Q5I2M8), TLR9_FELCA  (Q5I2M7), TLR9_HORSE  (Q2EEY0), 
TLR9_HUMAN  (Q9NR96), TLR9_MOUSE  (Q9EQU3), TLR9_PIG(Q5I2M3), 
TLR9_SHEEP  (Q5I2M4), TMVRN_NICGU (Q40392), TOLL6_DROME (Q9VUN0), 
TOLL7_DROME (Q7KIN0), TOLL8_DROME (Q9V477), TOLL_DROME  (P08953), 
VAP14_ARATH (Q9SYC9), VICTR_ARATH (F4KHI3), WR52N_ARATH (E1B328), 
WR52R_ARATH (C4B7M6), WR52W_ARATH (C4B7M5), WRK19_ARATH (Q9SZ67), 
WRK52_ARATH (P0DKH5), Y4117_ARATH (O82500), Y4CD_SINFN  (P55386), 
Y4LF_SINFN  (P55546), YDDK_BACSU  (P96648)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

6 sequences

CAP12_AGGAC (A0A5D0EMF2), CAP12_CAPGB (A0A381HAP5), CAP12_FLADA (P0DUD9),

CAP12_LACSX (P0DUE0), CAP12_NIADE (A0A1G6LGU2), CAP12_SPHFK (A0A2T5Y4G4)

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PDB
[Detailed view]

99 PDB

1FYV; 1FYW; 1FYX; 1O77; 1T3G; 2J67; 2JS7; 2M1W; 2M1X; 2NDH; 2Y92; 2Z5V;
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