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PROSITE entry PS50086


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50086
Entry name [info] TBC_RABGAP
Accession [info] PS50086
Entry type [info] MATRIX
Date [info] 01-OCT-2002 CREATED;
26-FEB-2020 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50086
Associated ProRule [info] PRU00163

Name and characterization of the entry

Description [info] TBC/rab GAP domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=194;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=189;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4819000; R2=0.0163304; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4067.4421387; R2=11.7770815; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=369; H_SCORE=8413; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=247; H_SCORE=6976; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-50; I=-50; B1=-1000; E1=-1000; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 173 in 173 different sequences
Number of true positive hits 173 in 173 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 15
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 92.02 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] Rab-GAP TBC
Version [info] 7

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
173 sequences

BUB2_DICDI  (Q55EP9), BUB2_YEAST  (P26448), CDC16_SCHPO (P36618), 
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UniProtKB/Swiss-Prot
False negative sequences
15 sequences

BROMI_DANRE (Q5RHR6), BROMI_HUMAN (Q96NH3), BROMI_MOUSE (Q3URV1), 
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PDB
[Detailed view]
18 PDB

1FKM; 2G77; 2QFZ; 2QQ8; 3HZJ; 3QWL; 3QYB; 3QYE; 4HL4; 4HLQ; 4NC6; 4Z6Y;
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