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PROSITE entry PS50042


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50042
Entry name [info] CNMP_BINDING_3
Accession [info] PS50042
Entry type [info] MATRIX
Date [info] 01-NOV-1997 CREATED;
26-FEB-2020 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00691
Associated ProRule [info] PRU00060

Name and characterization of the entry

Description [info] cAMP/cGMP binding motif profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=120;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=115;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.7862000; R2=0.0194000; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4941.5795898; R2=12.9449272; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=1; SCORE=398; H_SCORE=10094; N_SCORE=8.5; MODE=1; TEXT='!!';
/CUT_OFF: LEVEL=0; SCORE=321; H_SCORE=9097; N_SCORE=7.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=269; H_SCORE=8424; N_SCORE=6.0; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 494 in 348 different sequences
Number of true positive hits 485 in 339 different sequences
Number of 'unknown' hits 1
Number of false positive hits 8 in 8 different sequences
Number of false negative sequences 21
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 98.38 %
Recall (true positives / (true positives + false negatives)) 95.85 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 4
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] NP_BIND
Feature description [info] cNMP
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
339 sequences

AADR_RHOPA  (Q01980), ACH1_ARATH  (Q5FYU1), ACH2_ARATH  (F4HU51), 
» more

UniProtKB/Swiss-Prot
False negative sequences
21 sequences

ARCR_STAA1  (A7X715), ARCR_STAA2  (A6U515), ARCR_STAA3  (Q2FDM8), 
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UniProtKB/Swiss-Prot
'Unknown' sequences
1 sequence

CNNM4_HUMAN (Q6P4Q7)

		
UniProtKB/Swiss-Prot
False positive sequences
8 sequences

MHQE_BACSU  (O34543), NADK_BLOPB  (Q492C6), NINAB_GALME (A8Y9I2), 
» more

PDB
[Detailed view]
323 PDB

1CGP; 1CX4; 1G6N; 1HW5; 1I5Z; 1I6X; 1J59; 1LB2; 1NE4; 1NE6; 1O3Q; 1O3R;
» more