PROSITE logo

PROSITE entry PS50038


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50038
Entry name [info] FZ
Accession [info] PS50038
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50038
Associated ProRule [info] PRU00090

Name and characterization of the entry

Description [info] Frizzled (fz) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=122;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=117;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.2697001; R2=0.0105200; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=8104.8271484; R2=10.7967176; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=688; H_SCORE=15533; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=498; H_SCORE=13482; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;
...
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 111 in 108 different sequences
Number of true positive hits 111 in 108 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 9
Number of 'partial' sequences 4
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 92.50 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] P_Bucher
Feature key [info] DOMAIN
Feature description [info] FZ
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
108 sequences

CAM1_CAEEL  (G5EGK5), CBPZ_CHICK  (Q8QGP3), CBPZ_HUMAN  (Q66K79), 
» more

UniProtKB/Swiss-Prot
False negative sequences
9 sequences

FSLB_DICDI  (Q55CD6), FSLC_DICDI  (Q86J18), FSLD_DICDI  (Q55DT7), 
» more

UniProtKB/Swiss-Prot
'Partial' sequences
4 sequences

FZD3_CHICK  (Q9PTW3), FZD6_CHICK  (Q9PTW1), FZD8_CHICK  (Q9IA03), 
» more

PDB
[Detailed view]
70 PDB

1IJX; 1IJY; 2MAH; 3HKL; 4C79; 4C7A; 4F0A; 5BPB; 5BPQ; 5BQC; 5BQE; 5CL1;
» more