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PROSITE entry PS50014


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50014
Entry name [info] BROMODOMAIN_2
Accession [info] PS50014
Entry type [info] MATRIX
Date [info] 01-NOV-1995 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00550
Associated ProRule [info] PRU00035

Name and characterization of the entry

Description [info] Bromodomain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=71;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=66;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.5829999; R2=0.0138000; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3864.0354004; R2=5.5673757; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=502; H_SCORE=6659; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=357; H_SCORE=5852; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-70; E1=-70; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 227 in 170 different sequences
Number of true positive hits 227 in 170 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 8
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 96.60 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 6
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] Bromodomain
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
170 sequences

ASH1L_HUMAN (Q9NR48), ASH1L_MOUSE (Q99MY8), ATAD2_HUMAN (Q6PL18), 
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UniProtKB/Swiss-Prot
False negative sequences
8 sequences

ATD22_SCHPO (Q9C0W2), ATD2_SCHPO  (O14114), BRM_ARATH   (Q6EVK6), 
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PDB
[Detailed view]
2211 PDB

1E6I; 1EQF; 1F68; 1JM4; 1JSP; 1N72; 1WUG; 1WUM; 1X0J; 1ZS5; 2D82; 2D9E;
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