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PROSITE entry PS50011


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50011
Entry name [info] PROTEIN_KINASE_DOM
Accession [info] PS50011
Entry type [info] MATRIX
Date [info] 01-NOV-1995 CREATED;
01-OCT-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00100
Associated ProRule [info] PRU00159

Name and characterization of the entry

Description [info] Protein kinase domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=259;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=254;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2664; R2=0.014134; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=434; N_SCORE=8.4; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=300; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=*; E1=*; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 4'499 in 4'433 different sequences
Number of true positive hits 4'488 in 4'422 different sequences
Number of 'unknown' hits 0
Number of false positive hits 11 in 11 different sequences
Number of false negative sequences 243
Number of 'partial' sequences 5
Precision (true positives / (true positives + false positives)) 99.76 %
Recall (true positives / (true positives + false negatives)) 94.86 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] P_Bucher
Feature key [info] DOMAIN
Feature description [info] Protein kinase
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
4422 sequences

019R_FRG3G  (Q6GZV6), 044L_IIV3   (Q197B6), 389L_IIV6   (Q91FD5), 
» more

UniProtKB/Swiss-Prot
False negative sequences
243 sequences

AB1K7_ARATH (B9DGY1), AB1K8_ARATH (Q93Y08), ABC1_ARATH  (Q9SBB2), 
» more

UniProtKB/Swiss-Prot
'Partial' sequences
5 sequences

DYR1A_RABIT (P85051), EGFR_CHICK  (P13387), IGF1R_PIG   (Q29000), 
» more

UniProtKB/Swiss-Prot
False positive sequences
11 sequences

KDKA_PHODP  (P58551), KDKA_VIBCH  (Q9KVB9), KDKA_VIBPA  (Q87T74), 
» more

PDB
[Detailed view]
7237 PDB

1A06; 1A9U; 1AD5; 1AGW; 1APM; 1AQ1; 1ATP; 1B38; 1B39; 1B6C; 1BI7; 1BI8;
» more