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PROSITE entry PS50005


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50005
Entry name [info] TPR
Accession [info] PS50005
Entry type [info] MATRIX
Date [info] 01-JAN-2004 CREATED;
01-OCT-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50005
Associated ProRule [info] PRU00339

Name and characterization of the entry

Description [info] TPR repeat profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=34; TOPOLOGY=LINEAR;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=34;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3014; R2=0.0295; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=194; N_SCORE=8.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=92; N_SCORE=5.0; MODE=1; TEXT='R?';
/DEFAULT: D=-20; I=-20; B0=-100; B1=-200; E0=-100; E1=-200; MI=-105; MD=-50; IM=-105; DM=-50;
...
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Post-processing [info]

COMPETES_SEQ_WITH PS51375

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 3'547 in 876 different sequences
Number of true positive hits 3'488 in 860 different sequences
Number of 'unknown' hits 4 in 1 sequence
Number of false positive hits 55 in 15 different sequences
Number of false negative sequences 399
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 98.45 %
Recall (true positives / (true positives + false negatives)) 89.74 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 25
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann, N_Hulo
Feature key [info] REPEAT
Feature description [info] TPR
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
860 sequences

ACL4_EMENI  (C8V3W6), ACL4_SCHPO  (Q1MTN8), ACSC_KOMXY  (P37718), 
» more

UniProtKB/Swiss-Prot
False negative sequences
399 sequences

ACL4_YEAST  (Q03771), AFSR_STRGR  (Q9S0Y6), AIPL1_BOVIN (Q95MP1), 
» more

UniProtKB/Swiss-Prot
'Unknown' sequences
1 sequence

CDC16_CAEEL (G5EG38)

		
UniProtKB/Swiss-Prot
False positive sequences
15 sequences

CLF1_ASPFU  (Q4WT84), CLF1_CRYNB  (P0CO11), CLF1_CRYNH  (Q9HF03), 
» more

PDB
[Detailed view]
508 PDB

1A17; 1E96; 1ELR; 1ELW; 1FCH; 1HH8; 1IHG; 1IIP; 1IYG; 1KT0; 1KT1; 1NZN;
» more