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PROSITE entry PS50004


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50004
Entry name [info] C2
Accession [info] PS50004
Entry type [info] MATRIX
Date [info] 01-NOV-1995 CREATED;
07-APR-2021 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00380
Associated ProRule [info] PRU00041

Name and characterization of the entry

Description [info] C2 domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=120;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=120;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.0048385; R2=0.0071017; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=14820.3730469; R2=7.9307342; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1126; H_SCORE=23750; N_SCORE=9.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=774; H_SCORE=20959; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-11; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
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Post-processing [info]

COMPETES_HIT_WITH PS51547

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 1'076 in 673 different sequences
Number of true positive hits 1'076 in 673 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 4
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.63 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 7
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] C2
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
673 sequences

ABR_BOVIN   (A6QNS3), ABR_HUMAN   (Q12979), ABR_MOUSE   (Q5SSL4), 
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UniProtKB/Swiss-Prot
False negative sequences
4 sequences

CERI1_PLAF7 (O96188), CERI2_PLAF7 (Q8I1X7), CTSRT_MOUSE (A0A5F8MPU3), 
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PDB
[Detailed view]
202 PDB

1A25; 1BCI; 1BDY; 1BYN; 1CJY; 1DJG; 1DJH; 1DJI; 1DJW; 1DJX; 1DJY; 1DJZ;
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