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PROSITE entry PS00137


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00137
Entry name [info] SUBTILASE_HIS
Accession [info] PS00137
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00125
Associated ProRule [info] PRU10081

Name and characterization of the entry

Description [info] Serine proteases, subtilase family, histidine active site.
Pattern [info] 
H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-[SAGM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 247 in 247 different sequences
Number of true positive hits 232 in 232 different sequences
Number of 'unknown' hits 0
Number of false positive hits 15 in 15 different sequences
Number of false negative sequences 8
Number of 'partial' sequences 7
Precision (true positives / (true positives + false positives)) 93.93 %
Recall (true positives / (true positives + false negatives)) 96.67 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 232 sequences 

AEP_YARLI   (P09230), AEX5_CAEEL  (P91863), ALP2_ASPFC  (B0Y473),
» more

UniProtKB/Swiss-Prot
False negative sequences		 8 sequences 

NALP_NEIMB  (Q9JXM7), NALP_NEIMH  (E6MVD9), SBT1_LOTJA  (A9QY40),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 7 sequences 

ASE2_ACRSP  (P85157), CUDP_METCM  (P80406), NCP3_COPCM  (P83454),
» more

UniProtKB/Swiss-Prot
False positive sequences		 15 sequences 

ADCY8_HUMAN (P40145), ADCY8_MOUSE (P97490), ADCY8_RAT   (P40146),
» more

PDB
[Detailed view]		 439 PDB

1A2Q; 1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1AV7; 1AVT; 1BE6; 1BE8; 1BFK; 1BFU;
» more