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PROSITE entry PS00109


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00109
Entry name [info] PROTEIN_KINASE_TYR
Accession [info] PS00109
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00100
Associated ProRule [info] PRU10028

Name and characterization of the entry

Description [info] Tyrosine protein kinases specific active-site signature.
Pattern [info] 
[LIVMFYC]-{A}-[HY]-x-D-[LIVMFY]-[RSTAC]-{D}-{PF}-N-[LIVMFYC](3).

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 651 in 651 different sequences
Number of true positive hits 592 in 592 different sequences
Number of 'unknown' hits 0
Number of false positive hits 59 in 59 different sequences
Number of false negative sequences 17
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 90.94 %
Recall (true positives / (true positives + false negatives)) 97.21 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 592 sequences 

7LESS_DROME (P13368), 7LESS_DROVI (P20806), 7TMK1_DICDI (Q54N73),
ยป more

UniProtKB/Swiss-Prot
False negative sequences		 17 sequences 

BLK_HUMAN   (P51451), BLK_MOUSE   (P16277), BUD32_ENCCU (Q8SVD9),
ยป more

UniProtKB/Swiss-Prot
'Partial' sequences		 3 sequences 

EGFR_CHICK  (P13387), IGF1R_PIG   (Q29000), INSR_MACMU  (Q28516)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			59 sequences
			


			
ACD10_HUMAN (Q6JQN1), ACD10_MOUSE (Q8K370), ACD11_CHICK (Q5ZHT1), 

			
			ยป more
			


				
	

	

		PDB
[Detailed view]		
		
			1891 PDB
			


			1AD5; 1AGW; 1BYG; 1FGI; 1FGK; 1FMK; 1FPU; 1FVR; 1GAG; 1GJO; 1I44; 1IEP; 
			
			

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