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ENZYME

ENZYME entry: EC 3.5.1.89

Accepted Name
N-acetylglucosaminylphosphatidylinositol deacetylase
Alternative Name(s)
acetylglucosaminylphosphatidylinositol deacetylase
GlcNAc-PI deacetylase
GlcNAc-PI de-N-acetylase
N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase
N-acetylglucosaminylphosphatidylinositol de-N-acetylase
Reaction catalysed
a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O <=> acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol
Comment(s)
  • Involved in the second step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes.
  • The enzyme appears to be composed of a single subunit (PIG-L in mammalian cells and GPI12 in Saccharomyces cerevisiae).
  • In some species, the long-chain sn-1-acyl group of the phosphatidyl group is replaced by a long-chain alkyl or alk-1-enyl group.
  • Formerly EC 3.1.1.69.
Cross-references
BRENDA3.5.1.89
EC2PDB3.5.1.89
ExplorEnz3.5.1.89
PRIAM enzyme-specific profiles3.5.1.89
KEGG Ligand Database for Enzyme Nomenclature3.5.1.89
IUBMB Enzyme Nomenclature3.5.1.89
IntEnz3.5.1.89
MEDLINEFind literature relating to 3.5.1.89
MetaCyc3.5.1.89
Rhea expert-curated reactions3.5.1.89
UniProtKB/Swiss-Prot
D4B4K9, GPI12_ARTBCQ9HDW9, GPI12_SCHPOP23797, GPI12_YEAST
A6QQ24, PIGL_BOVINQ54C64, PIGL_DICDIQ9Y2B2, PIGL_HUMAN
Q5SX19, PIGL_MOUSEO35790, PIGL_RAT

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